Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Rebecca C. Larson"'
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher W. Mount, Ana P. Castano, Won-Ho Lee, Amanda A. Bouffard, Hana N. Takei, Antonio J. Almazan, Irene Scarfó, Trisha R. Berger, Andrea Schmidts, Matthew J. Frigault, Kathleen M. E. Gallagher, Marcela V. Maus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence s
Externí odkaz:
https://doaj.org/article/008a498ec868469ca7437a0db7630ab9
Autor:
Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus, Feng Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Loss-of-function CRISPR-based screens have identified several genes associated with cancer resistance to T cell-induced cytotoxicity. Here the authors perform a genome-scale, gain-of-function CRISPR screen and identify candidate genes, including the
Externí odkaz:
https://doaj.org/article/a70e38758d81453c93fd04c1608e57b4
Autor:
Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3248-3260 (2019)
Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BC
Externí odkaz:
https://doaj.org/article/744190eefb7f4eac95dde4520a55224b
Autor:
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter, Marcela V. Maus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfun
Externí odkaz:
https://doaj.org/article/987e2dc848b84c4ebabd4c5eacf43cbb
Autor:
Kimberly R. Hagel, Rand Arafeh, Sydney Gang, Taylor E. Arnoff, Rebecca C. Larson, John G. Doench, Nathan D. Mathewson, Kai W. Wucherpfennig, Marcela V. Maus, William C. Hahn
Publikováno v:
Cancer Research. 83:613-625
Chimeric antigen receptor (CAR) T-cell therapy can lead to dramatic clinical responses in B-cell malignancies. However, early clinical trials with CAR T-cell therapy in non–B-cell malignancies have been disappointing to date, suggesting that tumor-
Autor:
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other c
Externí odkaz:
https://doaj.org/article/1383b25b9a8e4f49a0640c17e9556951
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Chimeric antigen receptor (CAR) T cells induce impressive responses in patients with hematologic malignancies but can also trigger cytokine release syndrome (CRS), a systemic toxicity caused by activated CAR T cells and innate immune cells. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a6031fbfb084825435cf50718e629
https://doi.org/10.1158/2643-3230.c.6550641.v1
https://doi.org/10.1158/2643-3230.c.6550641.v1
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Supplementary Figure from Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3c245ac8ad9968ea117670a5ca1743
https://doi.org/10.1158/2643-3230.22544430
https://doi.org/10.1158/2643-3230.22544430
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Supplementary Data from Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892263e8db1e6f8b8ce430812e98389b
https://doi.org/10.1158/2643-3230.22544433
https://doi.org/10.1158/2643-3230.22544433