Výsledky vyhledávání - "Rebecca C. Feiner"

Akademický článek

Peptide stapling by late-stage Suzuki–Miyaura cross-coupling

Autor: Hendrik Gruß, Rebecca C. Feiner, Ridhiwan Mseya, David C. Schröder, Michał Jewgiński, Kristian M. Müller, Rafał Latajka, Antoine Marion, Norbert Sewald

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1-12 (2022)

The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein–protein interactions, which had been considered undruggable for a long time. We disclose a nove

Externí odkaz: https://doaj.org/article/b1e73b21829c4343991dd07924fa3253

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Tuning the Biological Activity of RGD Peptides with Halotryptophans

Autor: Rebecca C. Feiner, David C. Schröder, Antoine Marion, Norbert Sewald, Isabell Kemker, Kristian M. Müller

Publikováno v: Journal of Medicinal Chemistry. 64:586-601

An array of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation of haloindoles using tryptophan synthase. Introduction of these Trp derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1771d700ac252daab0af281815a9e64
https://doi.org/10.1021/acs.jmedchem.0c01536

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EGF-mCherry Fusion Protein Expressed in E. coli Shows Product Heterogeneity but a High Biological Activity

Autor: Ina Pennè, Benjamin Müller, Kristian M. Müller, Rebecca C. Feiner

Publikováno v: Biochemistry. 58:1043-1047

The epidermal growth factor receptor (EGFR) is a transmembrane protein involved in cell signaling processes, and dysregulation of its activity often drives tumor growth. EGFR is a clinically validated tumor marker and target for antibodies and tyrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0804907244f0d4a06e03b23bd189fc9a
https://doi.org/10.1021/acs.biochem.9b00021

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ChemInform Abstract: Modular Combination of Enzymatic Halogenation of Tryptophan with Suzuki-Miyaura Cross-Coupling Reactions

Autor: Christian Schnepel, Hannah Minges, Rebecca C. Feiner, Marcel Frese, Hauke Voss, Norbert Sewald

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8302aff6f79e774b34172facb9f7a65a
https://doi.org/10.1002/chin.201641074

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Recent progress in protein-protein interaction study for EGFR-targeted therapeutics

Autor: Rebecca C. Feiner, Kristian M. Müller

Introduction: Epidermal growth factor receptor (EGFR) expression is upregulated in many tumors and its aberrant signaling drives progression of many cancer types. Consequently, EGFR has become a clinically validated target as extracellular tumor mark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbad7540c4109795954b5a1e3a4783b
https://doi.org/10.1080/14789450.2016.1212665

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Modular Combination of Enzymatic Halogenation of Tryptophan with Suzuki-Miyaura Cross-Coupling Reactions

Autor: Marcel Frese, Christian Schnepel, Hannah Minges, Norbert Sewald, Hauke Voß, Rebecca C. Feiner

The combination of the biocatalytic halogenation of l-tryptophan with subsequent chemocatalytic Suzuki-Miyaura crosscoupling reactions leads to the modular synthesis of an array of C5, C6, or C7 aryl-substituted tryptophan derivatives. In a three-ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f48dcf2b73e5bd71803e286137562e
https://pub.uni-bielefeld.de/record/2905164

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