Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Rebecca C Wade"'
Autor:
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011436 (2023)
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificitie
Externí odkaz:
https://doaj.org/article/4dfce052391d4bef93bf212ea18e6e8b
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Olivia Eriksson, Upinder Singh Bhalla, Kim T Blackwell, Sharon M Crook, Daniel Keller, Andrei Kramer, Marja-Leena Linne, Ausra Saudargienė, Rebecca C Wade, Jeanette Hellgren Kotaleski
Publikováno v:
eLife, Vol 11 (2022)
Modeling in neuroscience occurs at the intersection of different points of view and approaches. Typically, hypothesis-driven modeling brings a question into focus so that a model is constructed to investigate a specific hypothesis about how the syste
Externí odkaz:
https://doaj.org/article/5b020307dca7438f80de560ebe023b42
Autor:
Neil J Bruce, Daniele Narzi, Daniel Trpevski, Siri C van Keulen, Anu G Nair, Ursula Röthlisberger, Rebecca C Wade, Paolo Carloni, Jeanette Hellgren Kotaleski
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007382 (2019)
Long-term potentiation and depression of synaptic activity in response to stimuli is a key factor in reinforcement learning. Strengthening of the corticostriatal synapses depends on the second messenger cAMP, whose synthesis is catalysed by the enzym
Externí odkaz:
https://doaj.org/article/c00384da16144b51bcdd289e5da3e784
Autor:
Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty, Timothy G Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C Wade, Michael P Barrett, Christine Clayton
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007315 (2018)
Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential
Externí odkaz:
https://doaj.org/article/e1674f3ac3f24f8baaf483e779b5f349
Autor:
Ross G Douglas, Prajwal Nandekar, Julia-Elisabeth Aktories, Hirdesh Kumar, Rebekka Weber, Julia M Sattler, Mirko Singer, Simone Lepper, S Kashif Sadiq, Rebecca C Wade, Friedrich Frischknecht
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005345 (2018)
Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments. In metazoans, monomeric actin polymerises into usually long and stable filaments, while some protozoans form only short a
Externí odkaz:
https://doaj.org/article/c6c8f9fb8e4f4b53adfba2f20276c044
Autor:
Catherine A Moreau, Saligram P Bhargav, Hirdesh Kumar, Katharina A Quadt, Henni Piirainen, Léanne Strauss, Jessica Kehrer, Martin Streichfuss, Joachim P Spatz, Rebecca C Wade, Inari Kursula, Friedrich Frischknecht
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006412 (2017)
Profilin is an actin monomer binding protein that provides ATP-actin for incorporation into actin filaments. In contrast to higher eukaryotic cells with their large filamentous actin structures, apicomplexan parasites typically contain only short and
Externí odkaz:
https://doaj.org/article/39be23259baa48b2af725aa8551bff17
Autor:
Nadinath B Nillegoda, Antonia Stank, Duccio Malinverni, Niels Alberts, Anna Szlachcic, Alessandro Barducci, Paolo De Los Rios, Rebecca C Wade, Bernd Bukau
Publikováno v:
eLife, Vol 6 (2017)
Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for
Externí odkaz:
https://doaj.org/article/a20258da37e549069a38cb1d780a7bdf
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104778 (2014)
Many signaling events require the binding of cytoplasmic proteins to cell membranes by recognition of specific charged lipids, such as phosphoinositol-phosphates. As a model for a protein-membrane binding site, we consider one charged phosphoinositol
Externí odkaz:
https://doaj.org/article/2412fd4844d6476da588edf7987fe798
Autor:
Nadine Veith, Anna Feldman-Salit, Vlad Cojocaru, Stefan Henrich, Ursula Kummer, Rebecca C Wade
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 7, p e1003159 (2013)
Pyruvate kinase (PYK) is a critical allosterically regulated enzyme that links glycolysis, the primary energy metabolism, to cellular metabolism. Lactic acid bacteria rely almost exclusively on glycolysis for their energy production under anaerobic c
Externí odkaz:
https://doaj.org/article/466e3faf1a6c49e89b43f69f130a89f6