Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Rebecca C Taylor"'
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6306 (2009)
BACKGROUND:There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains. He
Externí odkaz:
https://doaj.org/article/03f39098b5544012819fe7b69df8f1e0
Autor:
Emma M Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J Duriez, Rebecca C Taylor, Sean P Cullen, Colin Adrain, Seamus J Martin
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e5055 (2009)
Members of the caspase family of cysteine proteases coordinate cell death through restricted proteolysis of diverse protein substrates and play a conserved role in apoptosis from nematodes to man. However, while numerous substrates for the mammalian
Externí odkaz:
https://doaj.org/article/2694c5ed2a8849ef8cf7796054f2aa09
Autor:
Qosay Al-Balas, Nahoum G Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K Brown, Rebecca C Taylor, Gurdyal S Besra, Timothy D McHugh, Stephen H Gillespie, Blair F Johnston, Simon P Mackay, Geoffrey D Coxon
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5617 (2009)
BACKGROUND:Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug
Externí odkaz:
https://doaj.org/article/413cd2c2511c4f40966985336191077d
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The proteome of a cell helps to define its functional specialization. Most proteins must be translated and properly folded to ensure their biological function, but with aging, animals lose their ability to maintain a correctly folded proteome. This l
Externí odkaz:
https://doaj.org/article/4a8c28a2295f46dfa7036039c990fb51
Autor:
Rebecca C. Taylor, Mark E. Cook
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0400c163a9a0a2a189d1a487e15a4252
https://doi.org/10.1096/fasebj.2021.35.s1.03004
https://doi.org/10.1096/fasebj.2021.35.s1.03004
Autor:
Chen Lior, Veena Prahlad, Stuart K. Calderwood, Evandro A. De-Souza, Dimitra Bourboulia, Maurizio Zanetti, Rebecca C. Taylor, Patricija van Oosten-Hawle, Mark R. Wilson, D. Allan Drummond, Francesca Hodge, Lea Sistonen, Ruth Scherz-Shouval, R. Luke Wiseman, Richard I. Morimoto, Adrienne L. Edkins, Oded Rechavi, Della C. David
Publikováno v:
FASEB J
The FASEB journal 35(6), e21631 (2021). doi:10.1096/fj.202100566
2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, online, 2021-02-03-2021-02-04
The FASEB journal 35(6), e21631 (2021). doi:10.1096/fj.202100566
2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, online, 2021-02-03-2021-02-04
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6172c829a2d2a464494b2f435d268f3
https://pubmed.ncbi.nlm.nih.gov/34046940
https://pubmed.ncbi.nlm.nih.gov/34046940
Publikováno v:
Experimental Cell Research
Cellular stress responses exist to detect the effects of stress on cells, and to activate protective mechanisms that promote resilience. As well as acting at the cellular level, stress response pathways can also regulate whole organism responses to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfd9095d5b54a1580ec568793597692
http://europepmc.org/articles/PMC8363813
http://europepmc.org/articles/PMC8363813
Autor:
Rebecca C. Taylor, Claudio Hetz
Publikováno v:
Aging Cell
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a2b0d8ee807a729a8b67d37393f919
https://doi.org/10.1111/acel.13265
https://doi.org/10.1111/acel.13265
Autor:
Nadia, Cummins, Rebecca C, Taylor
Publikováno v:
Nature chemical biology
Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d962dca8da377a2fc43c74e18393e09f
https://pubmed.ncbi.nlm.nih.gov/32690944
https://pubmed.ncbi.nlm.nih.gov/32690944
Autor:
Jonathan A. G. Cox, Alistair K. Brown, Klaus Fütterer, Samuel Attoe, Rebecca C. Taylor, Gurdyal S. Besra
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The catabolism of fatty acids in mycobacteria involves an extensively redundant set of enzymes. Here, the structure of the l-3-hydroxyacyl-CoA dehydrogenase FadB2 is described and structural cues as to how it may work with other components of β-oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a768045844d5856efbcda3ae1c1633ad
https://doi.org/10.1107/s2059798318017242
https://doi.org/10.1107/s2059798318017242