Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rebecca C Obeng"'
Autor:
Peng Li, Haydn Kissick, Rebecca C Obeng, Tahseen H Nasti, Christiane S Eberhardt, Rafi Ahmed, Zhengjia Chen, Warren J Leonard, Suresh S Ramalingam, Andreas Wieland, Annapaola Mariniello, Jeffrey M Switchenko, Kylee Martens, Daniel Y Chang, Donald McGuire, Candace Daugherty, Yuzi Zhang, Rathi Pillai, Alice O Kamphorst
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Immune checkpoint inhibitors (ICI) that block the programmed cell death 1 (PD-1) pathway have shown promise with limited benefit. We and others have shown in small patient cohorts that an early proliferative CD8 T-cell response in the blood
Externí odkaz:
https://doaj.org/article/4cc0e384a52945fa895729f71406f6ed
Autor:
Victor H Engelhard, Rebecca C Obeng, Kara L Cummings, Angela L Ambakhutwala, Amanda Lulu, Paisley Myers, Keira E Mahoney, Donald F Hunt, Craig L Slingluff, Jr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Phosphorylated peptides presented by MHC molecules represent a new class of neoantigens expressed on cancer cells and recognized by CD8 T-cells. These peptides are promising targets for cancer immunotherapy. Previous work identified an HLA
Externí odkaz:
https://doaj.org/article/2f1ba13970c949eeb55d8d1382a456e4
Autor:
Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn T. Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James L. Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jorg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed
Publikováno v:
Nature. 610:173-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7851039a7e457c18b997947061dde5ce
https://doi.org/10.1038/s41586-022-05257-0
https://doi.org/10.1038/s41586-022-05257-0
Autor:
Wei Zheng, Rebecca C. Obeng, Rondell P. Graham, Shu Lui, Jerome Cheng, Borislav A. Alexiev, Brian Quigley, Alyssa Krasinskas, Guang-Yu Yang, David Escobar, Xiuli Liu, Pooja Navale, Michelle D. Reid, Maria Westerhoff, Yue Xue
Publikováno v:
American Journal of Surgical Pathology. 46:1500-1506
Kaposi sarcoma (KS) can pose diagnostic challenges in biopsy specimens. Multiple histologic variants of cutaneous KS have been described; however, the histomorphologic spectrum of gastrointestinal (GI) KS has not been systematically studied. This lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b357369825f088fa2f09278c92981fc
https://doi.org/10.1097/pas.0000000000001937
https://doi.org/10.1097/pas.0000000000001937
Autor:
Victor H. Engelhard, Craig L. Slingluff, Mark Conaway, Donna H. Deacon, Kara L. Cummings, Joel Pinczewski, A. Nicole Desch, Rebecca C. Obeng, Angela L. Zarling
Supplemental Figure 1. Sequence of pIRS-21097-1105 TCR chains. Supplemental Figure 2. Sequence of pCDC25b38-46 TCR chains. Supplemental Figure 3. Electroporation of IVT RNA encoding murine TCR chains results in functional cell surface expression of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487c7ebd428a56baf90a2dda7f5c4ffb
https://doi.org/10.1158/0008-5472.22403447
https://doi.org/10.1158/0008-5472.22403447
Autor:
Maria Cardenas, Mihir R. Patel, John Sidney, Alessandro Sette, Dong M. Shin, Mary Carrington, Tahseen H. Nasti, Haydn T. Kissick, Rafi Ahmed, Xu Wang, Zhuo Georgia Chen, Nataliya Prokhnevska, Andreas Wieland, Rebecca C. Obeng, Christopher C. Griffith, Se Jin Im, Nabil F. Saba, Christiane S Eberhardt
Publikováno v:
Nature
T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer1,2. Here we studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c82df87829409a7da3e01e474182c51
https://doi.org/10.1038/s41586-021-03862-z
https://doi.org/10.1038/s41586-021-03862-z
Autor:
Xu Wang, Haydn T. Kissick, Andreas Wieland, Nabil F. Saba, Mihir R. Patel, William H. Hudson, Rafi Ahmed, Christiane S Eberhardt, Zhuo Georgia Chen, Maria Cardenas, Christopher C. Griffith, Rebecca C. Obeng
Publikováno v:
Nature. 597:274-278
Tumours often contain B cells and plasma cells but the antigen specificity of these intratumoral B cells is not well understood1-8. Here we show that human papillomavirus (HPV)-specific B cell responses are detectable in samples from patients with HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db94c8ba3c3e8768a43c6d91389bdf5f
https://doi.org/10.1038/s41586-020-2931-3
https://doi.org/10.1038/s41586-020-2931-3
Autor:
Bahar Memis, Bassel F El-Rayes, Burcin Pehlivanoglu, Shishir K. Maithel, Michelle D. Reid, Hongmei Jiang, Rebecca C. Obeng, Yue Xue, Volkan Adsay, Juan M. Sarmiento, Shu K. Lui, Olca Basturk, David A. Kooby
Publikováno v:
Endocrine Pathology. 31:239-253
Better prognostication/stratification of pancreatic neuroendocrine tumors (PanNETs) is needed. In this detailed morpheomic study of 163 resected PanNETs, 11 unusual variants, some of which were not previously recognized, and others scarcely documente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dbf763861b770ee255211f0f4c53c3
https://doi.org/10.1007/s12022-020-09628-z
https://doi.org/10.1007/s12022-020-09628-z
Autor:
Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H. Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T. Gutierrez-Diaz, Marina V. Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E. Velu, Kavitha Sarma, Basil B. Mattamana, Byoung-Kyu Cho, Rebecca C. Obeng, Young Ah Goo, Philip W. Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos
Publikováno v:
Science Advances
SCIENCE ADVANCES
SCIENCE ADVANCES
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b85e27d019d55f418b8ed24476b33
https://doi.org/10.1126/sciadv.abj8357
https://doi.org/10.1126/sciadv.abj8357
Autor:
Masao, Hashimoto, Koichi, Araki, Maria A, Cardenas, Peng, Li, Rohit R, Jadhav, Haydn T, Kissick, William H, Hudson, Donald J, McGuire, Rebecca C, Obeng, Andreas, Wieland, Judong, Lee, Daniel T, McManus, James L, Ross, Se Jin, Im, Junghwa, Lee, Jian-Xin, Lin, Bin, Hu, Erin E, West, Christopher D, Scharer, Gordon J, Freeman, Arlene H, Sharpe, Suresh S, Ramalingam, Alex, Pellerin, Volker, Teichgräber, William J, Greenleaf, Christian, Klein, Jorg J, Goronzy, Pablo, Umaña, Warren J, Leonard, Kendall A, Smith, Rafi, Ahmed
Publikováno v:
Nature
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection(1). Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, unlike PD-1 monot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fcea5c144cecd334bc626c73ee2ee80
https://pubmed.ncbi.nlm.nih.gov/36171288
https://pubmed.ncbi.nlm.nih.gov/36171288