Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Rebecca C, Wade"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The dissociation rate, or its reciprocal, the residence time (τ), is a crucial parameter for understanding the duration and biological impact of biomolecular interactions. Accurate prediction of τ is essential for understanding protein-pro
Externí odkaz:
https://doaj.org/article/29dc03894da4488a9442900ec5645347
Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos
Autor:
Jessica Guerra, Mirella Belleri, Giulia Paiardi, Chiara Tobia, Davide Capoferri, Marzia Corli, Elisa Scalvini, Marco Ghirimoldi, Marcello Manfredi, Rebecca C. Wade, Marco Presta, Luca Mignani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1397-1407 (2024)
Krabbe disease is a sphingolipidosis characterized by the genetic deficiency of the acid hydrolase β-galactosylceramidase (GALC). Most of the studies concerning the biological role of GALC performed on Krabbe patients and Galc-deficient twitcher mic
Externí odkaz:
https://doaj.org/article/c98712cfb14b4da3a4a44f64229c80dd
Autor:
Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans,
Externí odkaz:
https://doaj.org/article/780a53ab9410470abce7ed5369ab372b
Autor:
Sumit Mukesh, Goutam Mukherjee, Ridhima Singh, Nathan Steenbuck, Carolina Demidova, Prachi Joshi, Abhay T. Sangamwar, Rebecca C. Wade
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract The propensity of poorly water-soluble drugs to aggregate at supersaturation impedes their bioavailability. Supersaturated amorphous drug-salt-polymer systems provide an emergent approach to this problem. However, the effects of polymers on
Externí odkaz:
https://doaj.org/article/6425b4ef35684fbc815f78a4f975586f
Autor:
M. Tanvir Rahman, M. Kristian Koski, Joanna Panecka-Hofman, Werner Schmitz, Alexander J. Kastaniotis, Rebecca C. Wade, Rik K. Wierenga, J. Kalervo Hiltunen, Kaija J. Autio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear. The structurally well-c
Externí odkaz:
https://doaj.org/article/d16d0b2bf48f43899654c6293ec0c770
Autor:
Hanno Schmidt, Katharina Mauer, Manuel Glaser, Bahram Sayyaf Dezfuli, Sören Lukas Hellmann, Ana Lúcia Silva Gomes, Falk Butter, Rebecca C. Wade, Thomas Hankeln, Holger Herlyn
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background With the expansion of animal production, parasitic helminths are gaining increasing economic importance. However, application of several established deworming agents can harm treated hosts and environment due to their low specific
Externí odkaz:
https://doaj.org/article/a3b5918acef8482ea504a636b130d8eb
Autor:
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011436 (2023)
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificitie
Externí odkaz:
https://doaj.org/article/4dfce052391d4bef93bf212ea18e6e8b
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105088- (2022)
Summary: Crowded environments are known to affect the diffusion of macromolecules, but their effects on the diffusion of small molecules are largely uncharacterized. We investigate how three protein crowders, bovine serum albumin (BSA), hen egg-white
Externí odkaz:
https://doaj.org/article/383cf24fed8443039b9241f39ee1fc0d
Autor:
Marcus Fabiano de Almeida Mendes, Marcelo de Souza Bragatte, Priscila Vianna, Martiela Vaz de Freitas, Ina Pöhner, Stefan Richter, Rebecca C. Wade, Francisco Mauro Salzano, Gustavo Fioravanti Vieira
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The therapeutic targeting of the immune system, for example in vaccinology and cancer treatment, is a challenging task and the subject of active research. Several in silico tools used for predicting immunogenicity are based on the analysis of peptide
Externí odkaz:
https://doaj.org/article/31458da310c644b9afa2706591cd33ca