Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rebecca Bruner-Klisovic"'
Autor:
Hsiaoyin Mao, Mario Notari, Ashwin Uttam, Rebecca Bruner-Klisovic, Shujun Liu, Clara D. Bloomfield, Mauro Valtieri, Michael A. Caligiuri, Danilo Perrotti, Rossana Trotta, Ji Suk Chang, Denis C. Roy, Ramasamy Santhanam, Bradley W. Blaser, Paolo Neviani, Annamaria Galietta, Guido Marcucci
Publikováno v:
Cancer Cell. 8:355-368
SummaryThe oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis (CML-BC) progenitors, the phosphatase activity of the tumor suppressor PP2A is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1a01a1cbebdf2126f402ed5828002b
https://doi.org/10.1016/j.ccr.2005.10.015
https://doi.org/10.1016/j.ccr.2005.10.015
Autor:
Rebecca Bruner-Klisovic, Stephen D. Nimer, Richard Stone, Michael R. Cooper, Jean-Michel Lecerf, Daniel J. De Angelo, Michael A. Caligiuri, Mark L. Heaney, Ronald Paquette, Brian J. Druker, Ganesh Iyer, Michael Heinrich
Publikováno v:
Blood. 104:1792-1792
MLN518 is a small molecule inhibitor of FLT3, PDGFR and c-Kit that is currently being evaluated as a therapy for AML. Previous phase I evaluation of MLN518 showed that it inhibits the phosphorylation of both wild-type and ITD-mutated FLT3 in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ef3cb4427f97b246d6400c4f308d1d
https://doi.org/10.1182/blood.v104.11.1792.1792
https://doi.org/10.1182/blood.v104.11.1792.1792
Autor:
Mauro Valtieri, Clara D. Bloomfield, Hsiaoyin Mao, Ji-Suk Chang, Danilo Perrotti, Rossana Trotta, Paolo Neviani, Bradley W. Blaser, Michael A. Caligiuri, Denis C. Roy, Rebecca Bruner-Klisovic, Joshua J. Oaks, Shujun Liu, Ramasamy Santhanam, Guido Marcucci, Mario Notari
Publikováno v:
ResearcherID
A tight control of kinase and phosphatase activity is fundamental for normal cell growth, survival and differentiation. The deregulated kinase activity of the BCR/ABL oncoprotein is responsible for the emergence and maintenance of chronic myelogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47601d582a41541345bcca92410d683
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000233426003354&KeyUID=WOS:000233426003354
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000233426003354&KeyUID=WOS:000233426003354
