Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rebecca Arcos"'
Autor:
Kyriakos P. Papadopoulos, Sameera R. Wijayawardana, Palaniappan Kulanthaivel, Rebecca Arcos, Louis Stancato, Claudia S. Kelly, Drew W. Rasco, Charles Erlichman, Janet Lensing, Peipei Shi, Matthew P. Goetz, Robert Bell, Anthony W. Tolcher, Julian R. Molina, Paul Haluska, Lynette B. Mulle, Amita Patnaik, Daphne L. Farrington, Edward M. Chan, Celine Pitou, Xuekui Zhang, Muralidhar Beeram
Publikováno v:
Clinical Cancer Research. 22:1095-1102
Purpose: p38 MAPK regulates the production of cytokines in the tumor microenvironment and enables cancer cells to survive despite oncogenic stress, radiotherapy, chemotherapy, and targeted therapies. Ralimetinib (LY2228820 dimesylate) is a selective
Autor:
Pamela Trail, Anthony W. Tolcher, Rebecca Arcos, Sharvina Ziyeh, Kyriakos P. Papadopoulos, Robin Kate Kelley, Katherine Van Loon, Lillian L. Siu, Israel Lowy, Muralidhar Beeram, Philippe L. Bedard, Albiruni Ryan Abdul Razak, Carrie Brownstein, Bo Gao, Lieve Adriaens
Publikováno v:
Journal of Clinical Oncology. 32:2540-2540
2540 Background: Nesvacumab (N) is an Ang2 selective, human MAb that potently blocks signaling through the Tie2 receptor, inhibiting tumor angiogenesis and growth. In mouse xenograft models of huma...
Autor:
Lon Smith, Michael J. Wick, Cally Claude Claiborne, Muralidhar Beeram, G. Mangold, Kyriakos P. Papadopoulos, Wei Peng, Cathy Alvarez, Rebecca Arcos, Allan J. White, Anthony W. Tolcher, Leslie Smetzer, Ronald L. Drengler, Drew W. Rasco, Amita Patnaik, Theresa Mays, Brianne Kaiser
Publikováno v:
Journal of Clinical Oncology. 32:e13509-e13509
e13509 Background: Targeted therapy of recurrent/metastatic ovarian and endometrial cancer remains of great interest but has not been established as standard of care. We analyzed a series of patien...
Autor:
Philippe L. Bedard, Lillian L. Siu, Rebecca Arcos, Israel Lowy, Amita Patnaik, Bo Gao, Solmaz Sahebjam, Carrie Brownstein, Robin Katie Kelley, Albiruni Ryan Abdul Razak, Lieve Adriaens, Anthony W. Tolcher, Pamela Trail, A. Thomas DiCioccio, Kyriakos P. Papadopoulos
Publikováno v:
Journal of Clinical Oncology. 31:2517-2517
2517 Background: REGN910 is a selective, fully human Ang2 MAb that potently blocks signaling through the Tie2 receptor regulating tumor angiogenesis and growth. In multiple mouse xenograft models of human solid tumors, REGN910 inhibits tumor growth.
Autor:
Celine Pitou, Kyriakos P. Papadopoulos, Janet Lensing, Matthew P. Goetz, Charles Erlichman, Rebecca Arcos, Lynette B. Mulle, Peipei Shi, Anthony W. Tolcher, Palaniappan Kulanthaivel, Drew W. Rasco, Edward M. Chan, Julian R. Molina, Muralidhar Beeram, Paul Haluska, Amita Patnaik
Publikováno v:
Journal of Clinical Oncology. 30:3001-3001
3001 Background: p38 MAPK regulates production of cytokines by the tumor microenvironment and its activation enables cancer cells to survive in the presence of oncogenic stress, radiation, chemotherapy, and targeted therapies. LY2228820 is a selectiv
Autor:
J. R. Infante, A.E. McGlothlin, H. A. Burris, Kyri Papadopoulos, Muralidhar Beeram, J. Leohr, Aejaz Nasir, Scott M. Hynes, Daphne L. Farrington, Amita Patnaik, Johanna C. Bendell, Rebecca Arcos, Kent C. Shih, Anthony W. Tolcher, J. T. Brandt, L. Jackson, Eric H. Westin
Publikováno v:
Journal of Clinical Oncology. 29:2600-2600
2600 Background: LY2523355 is an allosteric inhibitor of Eg5 which selectively inhibits bipolar mitotic spindle formation. The objective of this Phase 1 study is to determine the Phase 2 dose and s...
Autor:
Rebecca Arcos, Wei Zhang
Publikováno v:
Virology. (2):194-202
Adenovirus is one of the well-studied double-stranded DNA viruses. However, the mechanisms of its DNA packaging and virion assembly are still not fully understood. One of the unique features of adenovirus is that the unpackaged viral DNA is associate