Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Rebecca Aft"'
Autor:
Foluso O. Ademuyiwa, Donald W. Northfelt, Tracey O’Connor, Ellis Levine, Jingqin Luo, Yu Tao, Jeremy Hoog, Marie L. Laury, Tracy Summa, Trish Hammerschmidt, Zhanfang Guo, Ashley Frith, Katherine Weilbaecher, Mateusz Opyrchal, Rebecca Aft, Katherine Clifton, Rama Suresh, Nusayba Bagegni, Ian S. Hagemann, Michael D. Iglesia, Cynthia X. Ma
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Patients with ER+/HER2+ breast cancer (BC) are less likely to achieve pathological complete response (pCR) after chemotherapy with dual HER2 blockade than ER−/HER2+ BC. Endocrine therapy plus trastuzumab is effective in advanced ER+/HER2+
Externí odkaz:
https://doaj.org/article/49d5c74d8dba4b95b0b0ea0d7e2de4d4
Autor:
Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C. Wendl, Sherri R. Davies, Matthew H. Bailey, Tina M. Primeau, Jeremy Hoog, Jacqueline L. Mudd, Dennis A. Dean, Rajesh Patidar, Li Chen, Matthew A. Wyczalkowski, Reyka G. Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V. Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A. Van Tine, Cynthia X. Ma, Rebecca Aft, Katherine C. Fuh, Julie K. Schwarz, Jose P. Zevallos, Sidharth V. Puram, John F. Dipersio, The NCI PDXNet Consortium, Brandi Davis-Dusenbery, Matthew J. Ellis, Michael T. Lewis, Michael A. Davies, Meenhard Herlyn, Bingliang Fang, Jack A. Roth, Alana L. Welm, Bryan E. Welm, Funda Meric-Bernstam, Feng Chen, Ryan C. Fields, Shunqiang Li, Ramaswamy Govindan, James H. Doroshow, Jeffrey A. Moscow, Yvonne A. Evrard, Jeffrey H. Chuang, Benjamin J. Raphael, Li Ding
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Patient-derived xenograft models (PDX) have been extensively used to study the molecular and clinical features of cancers. Here the authors present a cohort of 536 PDX models from 25 cancers, as well as their genomic and evolutionary profiles and the
Externí odkaz:
https://doaj.org/article/e6286532f9bc487a87943a142621d7a3
Autor:
Sreeraj G Pillai, Chidananda M Siddappa, Cynthia Ma, Jackie Snider, Madhurima Kaushal, Mark A Watson, Rebecca Aft
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0246139 (2021)
Disseminated tumors cells (DTCs) present in the bone marrow (BM) are believed to be the progenitors of distant metastatic spread, a major cause of mortality in breast cancer patients. To better understand the behavior and therapeutic vulnerabilities
Externí odkaz:
https://doaj.org/article/3af3cf986c6a43bc892c6cb1ae69ef7c
Autor:
Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C. Wendl, Sherri R. Davies, Matthew H. Bailey, Tina M. Primeau, Jeremy Hoog, Jacqueline L. Mudd, Dennis A. Dean, Rajesh Patidar, Li Chen, Matthew A. Wyczalkowski, Reyka G. Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V. Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A. Van Tine, Cynthia X. Ma, Rebecca Aft, Katherine C. Fuh, Julie K. Schwarz, Jose P. Zevallos, Sidharth V. Puram, John F. Dipersio, The NCI PDXNet Consortium, Brandi Davis-Dusenbery, Matthew J. Ellis, Michael T. Lewis, Michael A. Davies, Meenhard Herlyn, Bingliang Fang, Jack A. Roth, Alana L. Welm, Bryan E. Welm, Funda Meric-Bernstam, Feng Chen, Ryan C. Fields, Shunqiang Li, Ramaswamy Govindan, James H. Doroshow, Jeffrey A. Moscow, Yvonne A. Evrard, Jeffrey H. Chuang, Benjamin J. Raphael, Li Ding
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/395184e65c5746b0adbbaf31dc3c4cc4
Autor:
Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J Ellis, Mark A. Watson, Rebecca Aft
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Abstract Background Disseminated tumor cells (DTCs) found in the bone marrow (BM) of patients with breast cancer portend a poor prognosis and are thought to be intermediaries in the metastatic process. To assess the clinical relevance of a mouse mode
Externí odkaz:
https://doaj.org/article/4670dcff66174ebfa34d987b76e577f7
Autor:
Shunqiang Li, Dong Shen, Jieya Shao, Robert Crowder, Wenbin Liu, Aleix Prat, Xiaping He, Shuying Liu, Jeremy Hoog, Charles Lu, Li Ding, Obi L. Griffith, Christopher Miller, Dave Larson, Robert S. Fulton, Michelle Harrison, Tom Mooney, Joshua F. McMichael, Jingqin Luo, Yu Tao, Rodrigo Goncalves, Christopher Schlosberg, Jeffrey F. Hiken, Laila Saied, Cesar Sanchez, Therese Giuntoli, Caroline Bumb, Crystal Cooper, Robert T. Kitchens, Austin Lin, Chanpheng Phommaly, Sherri R. Davies, Jin Zhang, Megha Shyam Kavuri, Donna McEachern, Yi Yu Dong, Cynthia Ma, Timothy Pluard, Michael Naughton, Ron Bose, Rama Suresh, Reida McDowell, Loren Michel, Rebecca Aft, William Gillanders, Katherine DeSchryver, Richard K. Wilson, Shaomeng Wang, Gordon B. Mills, Ana Gonzalez-Angulo, John R. Edwards, Christopher Maher, Charles M. Perou, Elaine R. Mardis, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 4, Iss 6, Pp 1116-1130 (2013)
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retaine
Externí odkaz:
https://doaj.org/article/1caf49e311cd490a9bd70c469f4ea5ca
Autor:
Andrew A. Davis, Leonel Hernandez-Aya, Jingqin Luo, Mateusz Opyrchal, Foluso O. Ademuyiwa, Nusayba A. Bagegni, Katherine K. Clifton, Jill Anderson, Trish Hammerschmidt, Leslie Nehring, David DeNardo, Mark Watson, Rebecca Aft, Cynthia Ma, Katherine Weilbaecher
Publikováno v:
Cancer Research. 83:P3-06
Background: Neoadjuvant immune checkpoint inhibition (ICI) in combination with chemotherapy is approved for patients with high-risk, early-stage triple-negative breast cancer (TNBC) based on improved outcomes in the KEYNOTE-522 trial. However, some p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ee39f9967d655e9eda0cfed9531ebd
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-07
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-07
Autor:
William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Bethany Anderson, Harold J. Burstein, Helen Chew, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Joanne Mortimer, Sameer A. Patel, Lori J. Pierce, Laura H. Rosenberger, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer Burns, Rashmi Kumar
Publikováno v:
Journal of the National Comprehensive Cancer Network. 20:691-722
The therapeutic options for patients with noninvasive or invasive breast cancer are complex and varied. These NCCN Clinical Practice Guidelines for Breast Cancer include recommendations for clinical management of patients with carcinoma in situ, inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f37b83971adf30fa541ea5b7edee776
https://doi.org/10.6004/jnccn.2022.0030
https://doi.org/10.6004/jnccn.2022.0030
Autor:
C. Alston. James, John M. Baer, Chong Zuo, Usman Y. Panni, Brett L. Knolhoff, Graham D. Hogg, Natalie L. Kingston, Liang-I Kang, Varintra E. Lander, Jingqin Luo, Yu Tao, Mark A. Watson, Rebecca Aft, Ryan C. Fields, William G. Hawkins, David G. DeNardo
Publikováno v:
Cancer Immunology Research.
Intratumoral T-cell dysfunction is a hallmark of pancreatic tumors, and efforts to improve dendritic cell (DC)-mediated T-cell activation may be critical in treating these immune therapy unresponsive tumors. Recent evidence indicates that mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0093927b38674f57bfb49aa070bc6253
https://doi.org/10.1158/2326-6066.cir-21-0946
https://doi.org/10.1158/2326-6066.cir-21-0946
Autor:
Matthew J. Ellis, Souzan Sanati, Hussam Al-Kateb, Maria Koehler, Cynthia Huang Bartlett, Kiran Vij, Caroline Bumb, Shana Thomas, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Michelle V. Lee, Zhanfang Guo, Helen Krontiras, Tina Hieken, Timothy J. Eberlein, Amy Cyr, William Gillanders, Timothy Moynihan, Timothy Hobday, Rebecca Aft, Julie Margenthaler, Karen S. Anderson, Rama Suresh, Foluso Ademuyiwa, Michael Naughton, Jeremy Hoog, Andres Forero, Matthew Goetz, Donald W. Northfelt, Jingqin Luo, Feng Gao, Cynthia X. Ma
Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) assessed the antiproliferative activity of the CDK4/6 inhibitor palbocicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5405b1d4db6a955a56275a7511589430
https://doi.org/10.1158/1078-0432.c.6527120.v1
https://doi.org/10.1158/1078-0432.c.6527120.v1
