Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rebecca A. Smirk"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Autor:
Karen S. Hartl, Steven M. Seiler, Guohua Zhao, William A. Slusarchyk, Eddie C.-K. Liu, Daniel L. Cheney, James Sutton, Robert Zahler, Rebecca A. Smirk, Scott A. Bolton, Steven Sheriff, Rushith Kumar Anumula, Zulan Pi, Jacobson Bruce L, Gregory S. Bisacchi, William A. Schumacher, Shung C. Wu, Treuner Uwe D, Sharon N. Bisaha, Anzhi Wei
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
In this Letter, we describe the synthesis of several nonamidine analogs of biaryl acid factor VIIa inhibitor 1 containing weakly basic or nonbasic P1 groups. 2-Aminoisoquinoline was found to be an excellent surrogate for the benzamidine group (compou
Autor:
Jun Li, Lawrence J. Kennedy, Shung Wu, Carrie Xu, Hossain Monshizadegan, Stanley R. Krystek, Robert Zahler, Thomas Harrity, Huiping Zhang, Daniel Meyers, Debra Search, Yongmi An, Chiehying Chang, Rebecca A. Smirk, Michael Cap, Rongan Zhang, Shiwei Tao, Bang-Chi Chen, Ngiap-Kie Lim, Hao Zhang, Peter T. W. Cheng, Litao Zhang, Lori Kunselman, Stephanie Y. Chen, Pratik Devasthale, Pathanjali Kadiyala, Andres S. Hernandez, Michael A. Blanar, Joseph A. Tino, Ranjan Mukherjee, Ying Wang, Xiang-Yang Ye, Chen Sean, Yan Shi, Kevin O’Malley, Bowman Miao, Scott A. Bolton, Zhi Lai, Rai Ajit Srivastava, Wei Wang, Vinayak Hosagrahara, Kenneth T. Locke, Denis E. Ryono, Denise Grimm, Lisa Zhang, Jodi K. Muckelbauer, Yi-Xin Li
Publikováno v:
Journal of medicinal chemistry. 53(7)
An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs h
Autor:
David S. Nirschl, Stanley R. Krystek, James C. Sutton, Daniel M. Camac, Ramakrishna Seethala, Jeffrey A. Robl, Rajasree Golla, James J. Li, Robert Zahler, Paul E. Morin, Haixia Wang, Rebecca A. Smirk, Cooper Christopher B, Mary Ellen K. Salyan, Katy Van Kirk, Zhengping Ma, Steven Sheriff, David A. Gordon, Ligaya M. Simpkins, Zheming Ruan, Robert D. Hutchins, Brian Carpenter, Akbar Nayeem, Lawrence G. Hamann, Shung C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
Several series of pyridine amides were identified as selective and potent 11beta-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH(2)SO(2), CH(2)S, CH(2)O, S, O, N, bond) between