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pro vyhledávání: '"Rebecca A. S. Palu"'
Autor:
Rebecca A. S. Palu, Elaine Ong, Kaitlyn Stevens, Shani Chung, Katie G. Owings, Alan G. Goodman, Clement Y. Chow
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 12, Pp 3995-4005 (2019)
Externí odkaz:
https://doaj.org/article/4545784ddd644bcea663b88220665b90
Autor:
Rebecca A S Palu, Clement Y Chow
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007557 (2018)
Endoplasmic reticulum (ER) stress is an important modifier of human disease. Genetic variation in response genes is linked to inter-individual differences in the ER stress response. However, the mechanisms and pathways by which genetic modifiers are
Externí odkaz:
https://doaj.org/article/0dddfa0e24b940c6b34b3a3e9bb31ebe
Autor:
Rebecca A S Palu, Carl S Thummel
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005978 (2016)
SIRT1 is a member of the sirtuin family of NAD+-dependent deacetylases, which couple cellular metabolism to systemic physiology. Although studies in mouse models have defined a central role for SIRT1 in maintaining metabolic health, the molecular mec
Externí odkaz:
https://doaj.org/article/aeb6cec4850f49b68da1efc5ab781755
Publikováno v:
G3 (Bethesda, Md.). 12(6)
Variation in the onset, progression, and severity of symptoms associated with metabolic disorders such as diabetes impairs the diagnosis and treatment of at-risk patients. Diabetes symptoms, and patient variation in these symptoms, are attributed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eda33b0bd69adf9c8227db73df69c84
https://pubmed.ncbi.nlm.nih.gov/35435227
https://pubmed.ncbi.nlm.nih.gov/35435227
Publikováno v:
Genetics
Endoplasmic reticulum (ER) stress-induced apoptosis is a primary cause and modifier of degeneration in a number of genetic disorders. Understanding how genetic variation influences the ER stress response and subsequent activation of apoptosis could i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32e4f5a2dce206b0ff2ac46d135e69f8
https://pubmed.ncbi.nlm.nih.gov/32047096
https://pubmed.ncbi.nlm.nih.gov/32047096
Publikováno v:
Molecular Metabolism
Objective A significant portion of the heritable risk for complex metabolic disorders cannot be attributed to classic Mendelian genetic factors. At least some of this missing heritability is thought to be due to the epigenetic influence of parental a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d03b459f187afcc30734d683d52fad02
https://pubmed.ncbi.nlm.nih.gov/28702320
https://pubmed.ncbi.nlm.nih.gov/28702320