Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rebecca A. Porrit"'
Autor:
Ana Paula Lombardi Pereira, Emily Aubuchon, Debbie P. Moreira, Malcolm Lane, Thacyana T. Carvalho, Thassio R. R. Mesquita, Youngho Lee, Timothy R. Crother, Rebecca A. Porritt, Waldiceu A. Verri, Magali Noval Rivas, Moshe Arditi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundKawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of coronary artery aneurysms (CAA) in affected chil
Externí odkaz:
https://doaj.org/article/bab04e8fb821462888b2d774045c3cc8
Autor:
Begüm Kocatürk, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E. Lane, Debbie Moreira, Shuang Chen, Michael C. Fishbein, Rebecca A. Porritt, Bernardo S. Franklin, Magali Noval Rivas, Moshe Arditi
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Externí odkaz:
https://doaj.org/article/a0eb2a653cd9486ea27c4d111fb8cbc5
Autor:
Altan Rentsendorj, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionOsteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed that glatiramer
Externí odkaz:
https://doaj.org/article/0841f2b649ca4207b40888b9d0da4ad7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C involves systemic hyperinflammation and multiorgan involvement, including s
Externí odkaz:
https://doaj.org/article/9d2a1635c46e42da826cee9dd68e7261
Autor:
Stefanie Marek-Iannucci, Asli D. Yildirim, Syed M. Hamid, Asli B. Ozdemir, Angela C. Gomez, Begüm Kocatürk, Rebecca A. Porritt, Michael C. Fishbein, Takao Iwawaki, Magali Noval Rivas, Ebru Erbay, Moshe Arditi
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology. Endoplasmic reticulum (ER) stress can activate the NLRP
Externí odkaz:
https://doaj.org/article/1391dd11537c40e5ba2ed822530a0f79
Autor:
Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androg
Externí odkaz:
https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab16
Autor:
Stefanie Marek-Iannucci, Asli B. Ozdemir, Debbie Moreira, Angela C. Gomez, Malcolm Lane, Rebecca A. Porritt, Youngho Lee, Kenichi Shimada, Masanori Abe, Aleksandr Stotland, David Zemmour, Sarah Parker, Elsa Sanchez-Lopez, Jennifer Van Eyk, Roberta A. Gottlieb, Michael C. Fishbein, Michael Karin, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Murine and human data suggest that the NLRP3–IL-1β pathway is the main driver of KD pathophysiology. NLRP3 can be activated during defective autophagy/mitophagy.
Externí odkaz:
https://doaj.org/article/8c3c23459c15468788622df34392f6d5
Autor:
Daisuke Maruyama, Begüm Kocatürk, Youngho Lee, Masanori Abe, Malcolm Lane, Debbie Moreira, Shuang Chen, Michael C. Fishbein, Rebecca A. Porritt, Magali Noval Rivas, Moshe Arditi
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Kawasaki disease (KD), an acute febrile childhood illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children. Experimental data from murine models of KD vasculitis and transcriptomics data gener
Externí odkaz:
https://doaj.org/article/98fba64e12d9447c86fc29af82429d09
Autor:
Rebecca A. Porritt, Carol Chase Huizar, Edward J. Dick, Shyamesh Kumar, Renee Escalona, Angela C. Gomez, Stefani Marek-Iannucci, Magali Noval Rivas, Jean Patterson, Thomas G. Forsthuber, Moshe Arditi, Mark Gorelik
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectiveKawasaki disease (KD) is the most common cause of acquired pediatric heart disease in the developed world. 10% of KD patients are resistant to front-line therapy, and no interventions exist to address secondary complications such as myocardi
Externí odkaz:
https://doaj.org/article/01b14a3efd3f4042a8c41acfc5780ac6
Autor:
Timothy R. Crother, Rebecca A. Porritt, Jargalsaikhan Dagvadorj, Gantsetseg Tumurkhuu, Anatoly V. Slepenkin, Ellena M. Peterson, Shuang Chen, Kenichi Shimada, Moshe Arditi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autophagy can either antagonize or promote intracellular bacterial growth, depending on the pathogen. Here, we investigated the role of autophagy during a pulmonary infection with the obligate intracellular pathogen, Chlamydia pneumoniae (CP). In mou
Externí odkaz:
https://doaj.org/article/1f7e389b850a42559f78451bd7be1600