Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rebecca A. Frake"'
Autor:
Mariana Pavel, So Jung Park, Rebecca A. Frake, Sung Min Son, Marco M. Manni, Carla F. Bento, Maurizio Renna, Thomas Ricketts, Fiona M. Menzies, Radu Tanasa, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dy
Externí odkaz:
https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b7
Autor:
Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, Carla F. Bento, Kristian Franze, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YA
Externí odkaz:
https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a7
Autor:
Carla F. Bento, David C. Rubinsztein, Mariella Vicinanza, Sung Min Son, Mariana Pavel, Peter Sterk, Cansu Karabiyik, So Jung Park, Farah H. Siddiqi, Rebecca A. Frake
Publikováno v:
Cell Death & Differentiation. 29:1055-1070
Autophagic decline is considered a hallmark of ageing. The activity of this intracytoplasmic degradation pathway decreases with age in many tissues and autophagy induction ameliorates ageing in many organisms, including mice. Autophagy is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc2c28068c26e59975abcab80b0112e
https://doi.org/10.1038/s41418-021-00903-y
https://doi.org/10.1038/s41418-021-00903-y
Autor:
So Jung, Park, Rebecca A, Frake, Cansu, Karabiyik, Sung Min, Son, Farah H, Siddiqi, Carla F, Bento, Peter, Sterk, Mariella, Vicinanza, Mariana, Pavel, David C, Rubinsztein
Publikováno v:
Cell death and differentiation. 29(5)
Autophagic decline is considered a hallmark of ageing. The activity of this intracytoplasmic degradation pathway decreases with age in many tissues and autophagy induction ameliorates ageing in many organisms, including mice. Autophagy is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43ac4b7c25a9b12a4f1b2464bd35d77b
https://pubmed.ncbi.nlm.nih.gov/34848853
https://pubmed.ncbi.nlm.nih.gov/34848853
Autor:
Fiona M. Menzies, Thomas Ricketts, David C. Rubinsztein, Sung Min Son, Mariana Pavel, Radu Tanasa, Rebecca A. Frake, Maurizio Renna, Carla F. Bento, Marco M. Manni, So Jung Park
Publikováno v:
Autophagy
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Funder: UK Dementia Research Institute
The factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Recent literature suggests that autophagy compromise may cause oppos
The factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Recent literature suggests that autophagy compromise may cause oppos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310846876d47567c033fc5c56747cf29
https://doi.org/10.1038/s41467-021-21882-1
https://doi.org/10.1038/s41467-021-21882-1
Publikováno v:
Journal of Clinical Investigation. 125:65-74
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9576a639cf385ceca8655ab865bae95
https://doi.org/10.1172/jci73944
https://doi.org/10.1172/jci73944
Autor:
Rebecca A. Frake, David C. Rubinsztein
Publikováno v:
The journal of the Royal College of Physicians of Edinburgh. 46(4)
On 3 October 2016, Japanese cell biologist Yoshinori Ohsumi was awarded the Nobel Prize in Physiology or Medicine ‘for his discoveries of mechanisms for autophagy'; autophagy being an intracellular degradation pathway that helps maintain cytoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da10b6ef090660e218ae854b167a53b
https://pubmed.ncbi.nlm.nih.gov/28504774
https://pubmed.ncbi.nlm.nih.gov/28504774