Výsledky vyhledávání - "Rebecca A. Falin"

Identification of Regulatory Phosphorylation Sites in a Cell Volume– and Ste20 Kinase–dependent ClC Anion Channel

Autor: Rebecca A. Falin, Rebecca Morrison, Kevin Strange, Amy-Joan L. Ham

Publikováno v: The Journal of General Physiology

Changes in phosphorylation regulate the activity of various ClC anion transport proteins. However, the physiological context under which such regulation occurs and the signaling cascades that mediate phosphorylation are poorly understood. We have exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c05a96a14d8b0c22b26405fdc567e0b
https://doi.org/10.1085/jgp.200810080

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Acute Downregulation of ENaC by EGF Involves the PY Motif and Putative ERK Phosphorylation Site

Autor: Calvin U. Cotton, Rebecca A. Falin

Publikováno v: The Journal of General Physiology

The epithelial sodium channel (ENaC) is expressed in a variety of tissues, including the renal collecting duct, where it constitutes the rate-limiting step for sodium reabsorption. Liddle's syndrome is caused by gain-of-function mutations in the β a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf27449886147a947f85ea7a49b641e7
https://doi.org/10.1085/jgp.200709775

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A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption

Autor: Calvin U. Cotton, Rebecca A. Falin, I. Elias Veizis

Publikováno v: American Journal of Physiology-Cell Physiology. 288:C1003-C1011

Receptor-mediated inhibition of amiloride-sensitive sodium absorption was observed in primary and immortalized murine renal collecting duct cell (mCT12) monolayers. The addition of epidermal growth factor (EGF) to the basolateral bathing solution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567a449951c4f35fc7f98bd43fb727c3
https://doi.org/10.1152/ajpcell.00213.2004

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C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling

Autor: Kevin Strange, Hiroaki Miyazaki, Rebecca A. Falin

Publikováno v: American journal of physiology. Cell physiology. 300(3)

Mammalian Ste20-like proline/alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinases phosphorylate and regulate cation-coupled Cl−cotransporter activity in response to cell volume changes. SPAK and OSR1 are activated via phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060e159d1f1dff09aeeced0c95a35f31
https://pubmed.ncbi.nlm.nih.gov/21160027

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