Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Rebecca A. Clewell"'
Autor:
Yaroslav Chushak, Rebecca A. Clewell
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 5, Iss , Pp 100097- (2024)
A variety of environmental and physiological conditions can cause oxidative stress that damage cellular components such as DNA, proteins and lipids. Oxidative stress is implicated in many human diseases including cancer, cardiovascular diseases, neur
Externí odkaz:
https://doaj.org/article/99caf0851c38421eb68032610915c3f1
Autor:
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard an
Externí odkaz:
https://doaj.org/article/c77f706ac85c49c3bc5d018511b024a1
Autor:
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo exposure. When c
Externí odkaz:
https://doaj.org/article/fcd7d8b3f0a74dc38672d8c4d72eb9ac
Autor:
Saad Haider, Michael B. Black, Bethany B. Parks, Briana Foley, Barbara A. Wetmore, Melvin E. Andersen, Rebecca A. Clewell, Kamel Mansouri, Patrick D. McMullen
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Efficient high-throughput transcriptomics (HTT) tools promise inexpensive, rapid assessment of possible biological consequences of human and environmental exposures to tens of thousands of chemicals in commerce. HTT systems have used relatively small
Externí odkaz:
https://doaj.org/article/b8192d7fd04c4982a628c821724c6ce5
Autor:
Rebecca A, Clewell, Harvey J, Clewell, Matthew W, Linakis, Charles A, Easley, Jacqueline N, Langmo, Joshua, Salley, Robinan, Gentry, Thomas, Rücker
Publikováno v:
Toxicology in Vitro. 82:105365
Reduced sperm counts have been observed in male rats in an extended one generation reproductive toxicity study (EOGRTS, OECD 443) following repeated administration of 300 mg/kg/day N-Methylmorpholine N-oxide (NMMO). However, no adverse effects on rep
Publikováno v:
Chemico-Biological Interactions. 301:112-127
Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy. Initial discovery that DNA mutation was the root of cancer led quickly to
Autor:
P. Robinan Gentry, Melvin E. Andersen, Janice W. Yager, Rebecca A. Clewell, Pergentino Balbuena, Harvey J. Clewell, Michael B. Black, Linda J. Pluta, Alina Efremenko
Publikováno v:
Toxicology. 461
Evidence from both in vivo and in vitro studies suggests that gene expression changes from long-term exposure to arsenite evolve markedly over time, including reversals in the direction of expression change in key regulatory genes. In this study, hum
Autor:
Miyoung Yoon, Rebecca A. Clewell, Chantel I. Nicolas, Jerry L. Campbell, Jeremy A. Leonard, Harvey J. Clewell, Alina Efremenko, Melvin E. Andersen, Yu-Mei Tan, Katherine Phillips, Patrick D. McMullen
Publikováno v:
Toxicol In Vitro
Advancements in measurement and modeling capabilities are providing unprecedented access to estimates of chemical exposure and bioactivity. With this influx of new data, there is a need for frameworks that help organize and disseminate information on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860210bee5556db4f1820d5500e0bd42
https://europepmc.org/articles/PMC8204916/
https://europepmc.org/articles/PMC8204916/
Autor:
Rebecca A. Clewell, Harvey J. Clewell, Matthew P. Longnecker, Warwick A. Anderson, Jerry L. Campbell, Rainer Otter, Colin M. North
A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-butylphthalate (DBP). Both pregnant rat and human time-course plasma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060bb354e0365264f9a64df57abd5a71
Autor:
Gina Song, Briana Foley, Tyler Beames, Daniel Doheny, Jessica K. Hartman, Patrick D. McMullen, Bethany Parks, Miyoung Yoon, Chad Deisenroth, Rebecca A. Clewell, Alina Efremenko
Publikováno v:
Toxicology and Applied Pharmacology. 355:112-126
Rising obesity rates worldwide have socio-economic ramifications. While genetics, diet, and lack of exercise are major contributors to obesity, environmental factors may enhance susceptibility through disruption of hormone homeostasis and metabolic p