Výsledky vyhledávání - "Rebecca A. Brachman"

Akademický článek

Antidepressant but Not Prophylactic Ketamine Administration Alters Calretinin and Calbindin Expression in the Ventral Hippocampus

Autor: Christina T. LaGamma, William W. Tang, Ashlea A. Morgan, Josephine Cecelia McGowan, Rebecca A. Brachman, Christine A. Denny

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Ketamine has been found to have rapid, long-lasting antidepressant effects in treatment-resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown that ketamine acts as a prophylactic to protect against the development

Externí odkaz: https://doaj.org/article/cade3c66031a49a2b5f3c3db65759f7f

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Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

Autor: Briana K. Chen, Donald W. Landry, Shi-Xian Deng, Xiaoming Xu, Christine A. Denny, Denis J. David, Victor M. Luna, Christina T LaGamma, Indira Mendez-David, Rebecca A. Brachman, Alain M. Gardier, Abhishek Shah, Thomas B. Cooper, Raymond F. Suckow

Publikováno v: Neuropsychopharmacology

Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ab22efe3b7a5a1bf0cf35723e91cde
https://doi.org/10.1038/s41386-020-0714-z

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IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

Autor: Jose L. Garrido, Matías A. Medina, Felipe Bravo, Sarah McGee, Francisco Fuentes-Villalobos, Mario Calvo, Yazmin Pinos, James W. Bowman, Christopher D. Bahl, Maria Ines Barria, Rebecca A. Brachman, Raymond A. Alvarez

Publikováno v: Cell reports. 39(9)

Despite SARS-CoV-2 being a "novel" virus, early detection of anti-spike IgG in severe COVID-19 patients may be caused by the amplification of humoral memory responses against seasonal coronaviruses. Here, we examine this phenomenon by characterizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664f6acc9815c4b2de15cd6c2cb0c2d9
https://pubmed.ncbi.nlm.nih.gov/35617962

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Ovarian hormones mediate the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice

Autor: Thomas B. Cooper, Xiaoming Xu, Raymond F. Suckow, Rebecca A. Brachman, Shi-Xian Deng, Donald W. Landry, Briana K. Chen, Christine A. Denny, Christina T. LaGamma

BACKGROUNDFemales are more likely than males to develop major depressive disorder (MDD) after exposure to stress. We previously reported that the administration of (R,S)-ketamine before stress can prevent stress-induced depressive-like behavior in ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5263d19a46b0837bf0fc338436096d

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Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

Autor: Josephine C. McGowan, Alain M. Gardier, Sean C. Lim, Jennifer N. Perusini, Christine A. Denny, Thu Ha Pham, René Hen, Denis J. David, Charlène Faye, Indira Mendez-David, Rebecca A. Brachman

Publikováno v: ResearcherID

Background Stress exposure is one of the greatest risk factors for psychiatric illnesses like major depressive disorder and posttraumatic stress disorder. However, not all individuals exposed to stress develop affective disorders. Stress resilience,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a044cfd85a1d7d3015347b6447e990b
https://doi.org/10.1016/j.biopsych.2015.04.022

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Ventral CA3 Activation Mediates Prophylactic Ketamine Efficacy Against Stress-Induced Depressive-Like Behavior

Autor: Rebecca A. Brachman, Alessia Mastrodonato, Christina T. LaGamma, Christine A. Denny, Alfred J. Robison, Ina Pavlova, Randy Martinez

Background We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f3049d6a6dd5d68f05b4a203629500
https://europepmc.org/articles/PMC6107435/

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Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress

Autor: Rebecca A. Brachman, Christine A. Denny, Alessia Mastrodonato, Alexander Kitayev, Niven R. Narain, Michael A. Kiebish, Christina T. LaGamma, Josephine C. McGowan, Collin Hill

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(9)

Recently, we have shown that ketamine given prior to stress exposure protects against the development of depressive-like behavior in mice. These data suggest that it may be possible to prevent the induction of affective disorders before they develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3296140463acb2c2caee7d597a9ab40
https://pubmed.ncbi.nlm.nih.gov/29599484

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Prophylactic Ketamine Attenuates Learned Fear

Autor: Yuval Neria, Rebecca A. Brachman, Sean C. Lim, Melina Tsitsiklis, Josephine C. McGowan, Christine A. Denny, Christina T. LaGamma

Ketamine has been reported to be an efficacious antidepressant for major depressive disorder and posttraumatic stress disorder. Most recently, ketamine has also been shown to be prophylactic against stress-induced depressive-like behavior in mice. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f291b8fdd26f8ffa6a128292df78cd5d
https://europepmc.org/articles/PMC5518899/

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