Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Rebecca A Mason"'
Autor:
Angeline S Andrew, Ting Hu, Jian Gu, Jiang Gui, Yuanqing Ye, Carmen J Marsit, Karl T Kelsey, Alan R Schned, Sam A Tanyos, Eben M Pendleton, Rebecca A Mason, Elaine V Morlock, Michael S Zens, Zhongze Li, Jason H Moore, Xifeng Wu, Margaret R Karagas
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51301 (2012)
Bladder cancer is the 4(th) most common cancer among men in the U.S. We analyzed variant genotypes hypothesized to modify major biological processes involved in bladder carcinogenesis, including hormone regulation, apoptosis, DNA repair, immune surve
Externí odkaz:
https://doaj.org/article/2bd3b44368954f89932e96d6094d03e7
Autor:
Michael Agrez, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Rebecca Sara Mason, Christopher Chandler, Terrence J. Piva, Kristofer Thurecht, Nicholas Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Benjamin Blyth, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew Hall, Hayley Gooding, Laura Gallagher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated upon UVR-induced DNA damage, is l
Externí odkaz:
https://doaj.org/article/f251f6ca5a284aecb13cf3fec110b151
Autor:
Radomir M. Slominski, Tae-Kang Kim, Zorica Janjetovic, Anna A. Brożyna, Ewa Podgorska, Katie M. Dixon, Rebecca S. Mason, Robert C. Tuckey, Rahul Sharma, David K. Crossman, Craig Elmets, Chander Raman, Anton M. Jetten, Arup K. Indra, Andrzej T. Slominski
Publikováno v:
Cancers, Vol 16, Iss 12, p 2262 (2024)
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and a high mortality rate. This review disc
Externí odkaz:
https://doaj.org/article/b60ae2d1867c466793431795178c02bc
Autor:
Warusavithana Gunawardena Manori De Silva, Vanessa Bernadette Sequeira, Chen Yang, Katie Marie Dixon, Andrew J. A. Holland, Rebecca Sara Mason, Mark Stephen Rybchyn
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5583 (2024)
Photoprotective properties of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) to reduce UV-induced DNA damage have been established in several studies. UV-induced DNA damage in skin such as single or double strand breaks is known to initiate several cellular
Externí odkaz:
https://doaj.org/article/2dd3b54bd1e6451ca3ae6e014be7bbb2
Autor:
Warusavithana Gunawardena Manori De Silva, Bianca Yuko McCarthy, Jeremy Han, Chen Yang, Andrew J. A. Holland, Harvey Stern, Katie Marie Dixon, Edith Kai Yan Tang, Robert Charles Tuckey, Mark Stephen Rybchyn, Rebecca Sara Mason
Publikováno v:
Metabolites, Vol 13, Iss 7, p 775 (2023)
The hormonal form of vitamin D3, 1,25(OH)2D3, reduces UV-induced DNA damage. UV exposure initiates pre-vitamin D3 production in the skin, and continued UV exposure photoisomerizes pre-vitamin D3 to produce “over-irradiation products” such as lumi
Externí odkaz:
https://doaj.org/article/98a1b9deb1454e63860cb4c73aa716ea
Autor:
Chen Yang, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Jim Matthews, Katie Marie Dixon, Andrew J. A. Holland, Arthur David Conigrave, Rebecca Sara Mason
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4921 (2023)
The calcium-sensing receptor (CaSR) is an important regulator of epidermal function. We previously reported that knockdown of the CaSR or treatment with its negative allosteric modulator, NPS-2143, significantly reduced UV-induced DNA damage, a key f
Externí odkaz:
https://doaj.org/article/74a5e7c6db1b49e6ab2ec6662da2b017
Autor:
Chen Yang, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Jim Matthews, Andrew J. A. Holland, Arthur David Conigrave, Rebecca Sara Mason
Publikováno v:
Photochemistry and Photobiology. 98:1157-1166
The epidermis maintains a cellular calcium gradient that supports keratinocyte differentiation from its basal layers (low) to outer layers (high) leading to the development of the stratum corneum, which resists penetration of UV radiation. The calciu
Autor:
Mark S. Rybchyn, Myriam Abboud, David A. Puglisi, Clare Gordon-Thomson, Tara C. Brennan-Speranza, Rebecca S. Mason, David R. Fraser
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3270 (2020)
Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most s
Externí odkaz:
https://doaj.org/article/13d004c6dc00453f9d2839cf1f77d762
Autor:
Rebecca S. Mason, Clare Gordon-Thomson, Mark S. Rybchyn, Vanessa B. Sequeira, Eric J. Song, Sally E. Carter, Wannit Tongkao-On, Katie M. Dixon
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1964-1977 (2013)
Exposure to sunlight is the major cause of skin cancer. Ultraviolet radiation (UV) from the sun causes damage to DNA by direct absorption and can cause skin cell death. UV also causes production of reactive oxygen species that may interact with DNA t
Externí odkaz:
https://doaj.org/article/669226bb9cee4c059c3f808cc111bb22
Autor:
Tara C. Brennan-Speranza, David Mor, Wenhan Chang, Zhiqiang Cheng, Arthur D. Conigrave, Mark S. Rybchyn, Rebecca S. Mason
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6509, p 6509 (2021)
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6509, p 6509 (2021)
We recently found that, in human osteoblasts, Homer1 complexes to Calcium-sensing receptor (CaSR) and mediates AKT initiation via mechanistic target of rapamycin complex (mTOR) complex 2 (mTORC2) leading to beneficial effects in osteoblasts including