High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells

Autor: Florian J. Groelly, Rebecca A. Dagg, Jonathan Mailler, Thanos D. Halazonetis, Madalena Tarsounas

Publikováno v: STAR Protocols, Vol 4, Iss 1, Pp 101970- (2023)

Summary: Cells experiencing DNA replication stress enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here we describe a protocol to identify at genome wide and at high resolution the g

Externí odkaz: https://doaj.org/article/474a7216b26e4b8d9a849050a8924633

Targeting DNA damage response pathways in cancer

Autor: Florian J. Groelly, Matthew Fawkes, Rebecca A. Dagg, Andrew N. Blackford, Madalena Tarsounas

Publikováno v: Nature Reviews Cancer. 23:78-94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b65eaa3c5b6eede9d31545a9a749343e
https://doi.org/10.1038/s41568-022-00535-5

The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

Autor: Loretta Lau, Yuchen Zhang, Sandra Sampl, Robert Lu, Roger R. Reddel, Yuan-Yin Chen, Medina Korkut-Demirbaş, Jeremy D. Henson, Rebecca A. Dagg, Joyce H. Y. Lee, Nancy Martin La Rotta, Klaus Holzmann

Publikováno v: Cancers
Volume 13
Issue 21
Cancers, Vol 13, Iss 5369, p 5369 (2021)

Simple Summary A clinical test for alternative-lengthening-of-telomeres (ALT) could assist with cancer diagnosis and monitoring of disease progression. ALT-targeted anticancer treatments are being developed; however, there is no appropriate companion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07917a4644f30cff7e0fd214409f63b6

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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Zechen, Chong, Oliver, Drechsel, Lewis Jonathan Dursi, Roland, Eils, Shadrielle M, G Espiritu, Robert, S Fulton, Shengjie, Gao, Josep L, L Gelpi, Mark, B Gerstein, Santiago, Gonzalez, Ivo, G Gut, Faraz, Hach, Michael, C Heinold, Jonathan, Hinton, Taobo, Hu, Vincent, Huang, Huang, Yi, Barbara, Hutter, David, R Jones, Jongsun, Jung, Natalie, Jäger, Hyung-Lae, Kim, Kortine, Kleinheinz, Sushant, Kumar, Yogesh, Kumar, Christopher, M Lalansingh, Ivica, Letunic, Dimitri, Livitz, Eric, Z Ma, Yosef, E Maruvka, R Jay Mashl, Andrew, Menzies, Ana, Milovanovic, Morten Muhlig Nielsen, Stephan, Ossowski, Nagarajan, Paramasivam, Jakob Skou Pedersen, Marc, D Perry, Montserrat, Puiggròs, Keiran, M Raine, Esther, Rheinbay, Romina, Royo, S Cenk Sahinalp, Iman, Sarrafi, Matthias, Schlesner, Jared, T Simpson, Lucy, Stebbings, Miranda, D Stobbe, Jon, W Teague, Grace, Tiao, David, Torrents, Jeremiah, A Wala, Jiayin, Wang, Sebastian, M Waszak, Joachim, Weischenfeldt, Michael, C Wendl, Johannes, Werner, 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Publikováno v: Nature Communications, 11(1):4748. Nature Publishing Group
Nature communications, 11(1):4748. Nature Publishing Group
Nature communications, 11 (1
NATURE COMMUNICATIONS
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-27 (2020)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, Weischenfeldt, J, Brunak, S, Ding, L, Favero, F, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Bailey, Matthew H; Meyerson, William U; Dursi, Lewis Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Kelso, Sean; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C; Wheeler, David A; Getz, Gad; Simpson, Jared T; Gerstein, Mark B; Ding, Li (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11(1), p. 4748. Springer Nature 10.1038/s41467-020-18151-y
Nature communications, vol 11, iss 1
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Nature Communications, 11, 1
Recercat. Dipósit de la Recerca de Catalunya
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, 11
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

MC3 Working Group: Rehan Akbani21, Pavana Anur22, Matthew H. Bailey1,2,3, Alex Buchanan9, Kami Chiotti9, Kyle Covington12,23, Allison Creason9, Li Ding1,2,3,20, Kyle Ellrott9, Yu Fan21, Steven Foltz1,2, Gad Getz8,14,15,16, Walker Hale12, David Haussl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79caf69aa08507159a37977adcb4937b
https://www.bib.irb.hr/1104730

Whole-genome landscapes of major melanoma subtypes

Autor: Anna Fitzgerald, John V. Pearson, Andrew J. Spillane, Loretta Lau, Nuria Lopez-Bigas, Peter Johansson, Catherine A. Shang, Richard A. Scolyer, John F. Thompson, Scott Wood, Valerie Jakrot, Peter Hersey, Katia Nones, Rebecca A. Dagg, Antonia L. Pritchard, Conrad Leonard, Andreas Behren, Varsha Tembe, Robyn P. M. Saw, Loris Mularoni, Nick Waddell, Mark Shackleton, Hojabr Kakavand, Ping Shang, Jean Y. Yang, Graham J. Mann, Radhakrishnan Sabarinathan, Gulietta M. Pupo, Ricardo De Paoli-Iseppi, Jonathan Cebon, Richard F. Kefford, Ricardo E. Vilain, Hilda A. Pickett, Stephen H. Kazakoff, Ludmil B. Alexandrov, Oliver Holmes, Nicholas K. Hayward, Nicola Waddell, Ken Dutton-Regester, Jonathan R. Stretch, Sean M. Grimmond, Felicity Newell, Qinying Xu, James S. Wilmott, Hazel Burke, Georgina V. Long, Sarah-Jane Schramm, Matthew A. Field, Ann-Marie Patch

Publikováno v: Nature
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cuta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f2ab6a6793452c916ee7c5c3158ef3
https://doi.org/10.1038/nature22071