Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rebecca A Capel"'
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Autor:
Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A. B. Burton
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP3 signalling has been linked to the
Externí odkaz:
https://doaj.org/article/29468d17e8584ec7a7b1825bc001c2d9
Autor:
Thamali Ayagama, Samuel J. Bose, Rebecca A. Capel, David A. Priestman, Georgina Berridge, Roman Fischer, Antony Galione, Frances M. Platt, Holger Kramer, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102949- (2021)
Summary: The importance of lysosomes in cardiac physiology and pathology is well established, and evidence for roles in calcium signaling is emerging. We describe a label-free proteomics method suitable for small cardiac tissue biopsies based on dens
Externí odkaz:
https://doaj.org/article/89182a514c6548768b6697ff55f84605
Autor:
Dominic G. Whittaker, Rebecca A. Capel, Maurice Hendrix, Xin Hui S. Chan, Neil Herring, Nicholas J. White, Gary R. Mirams, Rebecca-Ann B. Burton
Publikováno v:
Royal Society Open Science, Vol 8, Iss 4 (2021)
Hydroxychloroquine (HCQ), the hydroxyl derivative of chloroquine (CQ), is widely used in the treatment of rheumatological conditions (systemic lupus erythematosus, rheumatoid arthritis) and is being studied for the treatment and prevention of COVID-1
Externí odkaz:
https://doaj.org/article/6027e754acca489f9cf50d7efe2c4617
Autor:
Rebecca-Ann B. Burton, Jakub Tomek, Christina M. Ambrosi, Hege E. Larsen, Amy R. Sharkey, Rebecca A. Capel, Alexander D. Corbett, Samuel Bilton, Aleksandra Klimas, Guy Stephens, Maegan Cremer, Samuel J. Bose, Dan Li, Giuseppe Gallone, Neil Herring, Edward O. Mann, Abhinav Kumar, Holger Kramer, Emilia Entcheva, David J. Paterson, Gil Bub
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101334- (2020)
Summary: Cardiac stimulation via sympathetic neurons can potentially trigger arrhythmias. We present approaches to study neuron-cardiomyocyte interactions involving optogenetic selective probing and all-optical electrophysiology to measure activity i
Externí odkaz:
https://doaj.org/article/1bf96b0e36b34140aa42ebc9b7826702
Autor:
Thamali Ayagama, Philip D Charles, Samuel J Bose, Barry Boland, David A Priestman, Daniel Aston, Georgina Berridge, Roman Fisher, Adam P Cribbs, Qianqian Song, Gary R Mirams, Lisa Heather, Antony Galione, Neil Herring, Ulrich Schotten, Rebecca A Capel, Frances M Platt, Holger Krame, Sander Verheule, Rebecca AB Burton
SummaryEndolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL help facilitate elimination of damaged membrane and cytosolic proteins, protein aggregates, membranous organelles and also play an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7d6c55db8b271c1c4a8ef5f88e1cd3
https://doi.org/10.1101/2023.03.10.532119
https://doi.org/10.1101/2023.03.10.532119
Autor:
Zhaozheng Meng, Rebecca A Capel, Samuel J Bose, Erik Bosch, Sophia de Jong, Robert Planque, Antony Galione, Rebecca AB Burton, Alfonso Bueno-Orovio
Spontaneous calcium release by ryanodine receptors (RyRs) due to intracellular calcium overload results in delayed afterdepolarisations, closely associated with life-threatening arrhythmias. In this regard, inhibiting lysosomal calcium release by two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39030d8c98485ccaec44f65d5d9c256f
https://doi.org/10.1101/2022.11.09.515777
https://doi.org/10.1101/2022.11.09.515777
Autor:
Samuel J. Bose, Matthew Read, Rebecca A Capel, Emily Akerman, Thamali Ayagama, Angela Russell, Derek A Terrar, Manuela Zaccolo, Rebecca AB Burton
Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial specific target for AF therapy, and atrial IP3 signalling has been linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dda20271c99a120765268389f79bcaa
https://doi.org/10.1101/2022.01.06.475211
https://doi.org/10.1101/2022.01.06.475211
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (‘membrane clock’) and others to uptake and release of calcium from the sarcoplasmic ret
Externí odkaz:
https://doaj.org/article/52cf4c541eaf42df87500cb682cd12c1
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
The sino-atrial node (SAN) provides the electrical stimulus to initiate every heart beat. Cellular processes underlying this activity have been debated extensively, especially with regards to the role of intracellular calcium. We have used whole-cell
Externí odkaz:
https://doaj.org/article/21e174417edb4d24b79a5050ac771808