Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Rebecca A, Ihrie"'
Autor:
Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a m
Externí odkaz:
https://doaj.org/article/302796375aee43128c1c645409209e15
Autor:
Todd Bartkowiak, Sierra M. Lima, Madeline J. Hayes, Akshitkumar M. Mistry, Asa A. Brockman, Justine Sinnaeve, Nalin Leelatian, Caroline E. Roe, Bret C. Mobley, Silky Chotai, Kyle D. Weaver, Reid C. Thompson, Lola B. Chambless, Rebecca A. Ihrie, Jonathan M. Irish
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Radiographic contact of glioblastoma (GBM) tumors with the lateral ventricle and adjacent stem cell niche correlates with poor patient prognosis, but the cellular basis of this difference is unclear. Here, we reveal and functionally characterize dist
Externí odkaz:
https://doaj.org/article/29907ada4aa143a69143033c5dcfd8c4
Autor:
Mary-Bronwen L Chalkley, Rachel B Mersfelder, Maria Sundberg, Laura C Armstrong, Mustafa Sahin, Rebecca A Ihrie, Kevin C Ess
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292086 (2023)
Tuberous Sclerosis Complex (TSC) is a debilitating developmental disorder characterized by a variety of clinical manifestations. TSC is caused by mutations in the TSC1 or TSC2 genes, which encode the hamartin/tuberin proteins respectively. These prot
Externí odkaz:
https://doaj.org/article/d45f6b6c25b340218f4d2f8d48a9b3ea
Autor:
Peter A. Kropp, Gabrielle V. Rushing, Asa A. Brockman, Erin N. Z. Yu, Rebecca A. Ihrie, Maureen Gannon
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-5 (2020)
Abstract Background Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. Ivermectin and selamectin are common oral and topical treatmen
Externí odkaz:
https://doaj.org/article/e3afecc0737e4db3bff177d0ddd797e4
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
ObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an ins
Externí odkaz:
https://doaj.org/article/354932d88fd94326a2d6e702f1743c47
Autor:
Lindsay K. Klofas, Brittany P. Short, John P. Snow, Justine Sinnaeve, Gabrielle V. Rushing, Grant Westlake, Will Weinstein, Rebecca A. Ihrie, Kevin C. Ess, Robert P. Carson
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 104975- (2020)
Mutations in the DEPDC5 gene can cause epilepsy, including forms with and without brain malformations. The goal of this study was to investigate the contribution of DEPDC5 gene dosage to the underlying neuropathology of DEPDC5-related epilepsies. We
Externí odkaz:
https://doaj.org/article/4e646a01adac431c9cd9f0ce6204f464
Autor:
Nalin Leelatian, Justine Sinnaeve, Akshitkumar M Mistry, Sierra M Barone, Asa A Brockman, Kirsten E Diggins, Allison R Greenplate, Kyle D Weaver, Reid C Thompson, Lola B Chambless, Bret C Mobley, Rebecca A Ihrie, Jonathan M Irish
Publikováno v:
eLife, Vol 9 (2020)
A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. We introduce a machine learning algorithm, Risk Assessment Population IDentification (RAPID), that is uns
Externí odkaz:
https://doaj.org/article/4b0f2febcca2420290d9f64856a5a58a
Autor:
Rebecca J. Embalabala, Asa A. Brockman, Amanda R. Jurewicz, Jennifer A. Kong, Kaitlyn Ryan, Cristina D. Guinto, Arturo Álvarez-Buylla, Chin Chiang, Rebecca A. Ihrie
Publikováno v:
Cells, Vol 11, Iss 2, p 218 (2022)
The ventricular–subventricular zone (V-SVZ) is a postnatal germinal niche. It holds a large population of neural stem cells (NSCs) that generate neurons and oligodendrocytes for the olfactory bulb and (primarily) the corpus callosum, respectively.
Externí odkaz:
https://doaj.org/article/a0ae46c327a44206b07e0cfd7199e004
Publikováno v:
Seminars in Immunopathology. 45:3-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c996f83feef86af93f43511199fb9e
https://doi.org/10.1007/s00281-022-00976-y
https://doi.org/10.1007/s00281-022-00976-y
Autor:
Yu-Ping Yang, Haiting Ma, Alina Starchenko, Won Jae Huh, Wei Li, F. Edward Hickman, Qin Zhang, Jeffrey L. Franklin, Douglas P. Mortlock, Sabine Fuhrmann, Bruce D. Carter, Rebecca A. Ihrie, Robert J. Coffey
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1257-1267 (2017)
EGF receptor (EGFR) is a critical signaling node throughout life. However, it has not been possible to directly visualize endogenous Egfr in mice. Using CRISPR/Cas9 genome editing, we appended a fluorescent reporter to the C terminus of the Egfr. Hom
Externí odkaz:
https://doaj.org/article/96d2eed36eb44e84b0a4fd9e9366b41c