Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Rebecca A, Gladstone"'
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Streptococcus pneumoniae is a major cause of mortality globally. The introduction of pneumococcal conjugate vaccines (PCVs) has reduced the incidence of the targeted serotypes significantly, but expansion of non-targeted serotypes
Externí odkaz:
https://doaj.org/article/d53e7a721b12438496c7014fea3bcdc2
Autor:
Cebile Lekhuleni, Kedibone Ndlangisa, Rebecca A. Gladstone, Sopio Chochua, Benjamin J. Metcalf, Yuan Li, Jackie Kleynhans, Linda de Gouveia, Scott Hazelhurst, Ana D. S. Ferreira, Happy Skosana, Sibongile Walaza, Vanessa Quan, Susan Meiring, Paulina A. Hawkins, Lesley McGee, Stephen D. Bentley, Cheryl Cohen, Stephanie W. Lo, Anne von Gottberg, Mignon du Plessis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Invasive pneumococcal disease (IPD) due to non-vaccine serotypes after the introduction of pneumococcal conjugate vaccines (PCV) remains a global concern. This study used pathogen genomics to evaluate changes in invasive pneumococcal lineage
Externí odkaz:
https://doaj.org/article/428323113fd04185bfd8dcf4843186a7
Autor:
Tamim Khawaja, Tommi Mäklin, Teemu Kallonen, Rebecca A. Gladstone, Anna K. Pöntinen, Sointu Mero, Harry A. Thorpe, Ørjan Samuelsen, Julian Parkhill, Mateen Izhar, M. Waheed Akhtar, Jukka Corander, Anu Kantele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Multi-drug resistant (MDR) E. coli constitute a major public health burden globally, reaching the highest prevalence in the global south yet frequently flowing with travellers to other regions. However, our comprehension of the entire geneti
Externí odkaz:
https://doaj.org/article/d635e9e4516f48f2a27f06a072b4c6c3
Autor:
Sergio Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca A. Gladstone, Alfred Fillol-Salom, Jessica Loraine, Elaine Cloutman-Green, Pål J. Johnsen, Ørjan Samuelsen, Anna K. Pöntinen, François Cléon, Susana Chavez-Bueno, Miguel A. De la Cruz, Miguel A. Ares, Manivanh Vongsouvath, Agnieszka Chmielarczyk, Carolyne Horner, Nigel Klein, Alan McNally, Joice N. Reis, José R. Penadés, Nicholas R. Thomson, Jukka Corander, Peter W. Taylor, Alex J. McCarthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in
Externí odkaz:
https://doaj.org/article/e6fa52774e4f424f982560f7102a17a7
Autor:
Tommi Mäklin, Harry A. Thorpe, Anna K. Pöntinen, Rebecca A. Gladstone, Yan Shao, Maiju Pesonen, Alan McNally, Pål J. Johnsen, Ørjan Samuelsen, Trevor D. Lawley, Antti Honkela, Jukka Corander
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Opportunistic bacterial pathogen species frequently colonise the human gut as a normal part of the ecosystem but strain-level colonisation and competition dynamics in healthy hosts is yet to be established. Authors seek to understand the relationship
Externí odkaz:
https://doaj.org/article/8e93f7b998b34aaf9e526e352acf40b3
Autor:
David W. Cleary, Jessica Jones, Rebecca A. Gladstone, Karen L. Osman, Vanessa T. Devine, Johanna M. Jefferies, Stephen D. Bentley, Saul N. Faust, Stuart C. Clarke
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Streptococcus pneumoniae continues to cause significant disease burden. Whilst pneumococcal conjugate vaccines (PCV) have substantially reduced this burden, serotype replacement partially negates this success due to increased disease associa
Externí odkaz:
https://doaj.org/article/7f41cebd148a4f488ff778c756b319cf
Autor:
Jasmine M. L. Low, Rebecca V. Gladstone-Gallagher, Judi E. Hewitt, Conrad A. Pilditch, Joanne I. Ellis, Simon F. Thrush
Publikováno v:
Ecosystem Health and Sustainability, Vol 9 (2023)
Managing cumulative effects in coastal marine ecosystems and predicting outcomes of mitigation or restorative actions represent a major challenge globally for scientists and decision-makers. Cumulative effects arise from the combined impact of indivi
Externí odkaz:
https://doaj.org/article/5c3cddb4c0a34149bd889c6b777583af
Autor:
Rebecca V. Gladstone‐Gallagher, Judi E. Hewitt, Simon F. Thrush, Marco C. Brustolin, Anna Villnäs, Sebastian Valanko, Alf Norkko
Publikováno v:
Ecology and Evolution, Vol 11, Iss 11, Pp 6091-6103 (2021)
Abstract Despite a long history of disturbance–recovery research, we still lack a generalizable understanding of the attributes that drive community recovery potential in seafloor ecosystems. Marine soft‐sediment ecosystems encompass a range of h
Externí odkaz:
https://doaj.org/article/c77d4c9735284dad80d352d8227be805
Autor:
Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val F. Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems, Jukka Corander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors
Externí odkaz:
https://doaj.org/article/7681bee6cee34c6d8a4c06f210f980be
Autor:
Chrispin Chaguza, Madikay Senghore, Ebrima Bojang, Rebecca A. Gladstone, Stephanie W. Lo, Peggy-Estelle Tientcheu, Rowan E. Bancroft, Archibald Worwui, Ebenezer Foster-Nyarko, Fatima Ceesay, Catherine Okoi, Lesley McGee, Keith P. Klugman, Robert F. Breiman, Michael R. Barer, Richard A. Adegbola, Martin Antonio, Stephen D. Bentley, Brenda A. Kwambana-Adams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleo
Externí odkaz:
https://doaj.org/article/0e98e6e6394d47f4b1f34dfd27a30caf