Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rebecca, Whiteley"'
Autor:
Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ruth Román, Sara Talbot, Rebecca Whiteley, Nicolas Floc’h, Elizabeth Martínez-Pérez, Matthew J. Martin, Paul D. Smith, Ivana Sullivan, Mikkel G. Terp, Jamal Saeh, Cristina Marino-Buslje, Giulia Fabbri, Grace Guo, Man Xu, Cristian Tornador, Andrés Aguilar-Hernández, Noemí Reguart, Henrik J. Ditzel, Alejandro Martínez-Bueno, Núria Nabau-Moretó, Amaya Gascó, Rafael Rosell, J. Elizabeth Pease, Urszula M. Polanska, Jon Travers, Jelena Urosevic, Miguel A. Molina-Vila
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-24 (2023)
Abstract Background Drugs targeting the spindle assembly checkpoint (SAC), such as inhibitors of Aurora kinase B (AURKB) and dual specific protein kinase TTK, are in different stages of clinical development. However, cell response to SAC abrogation i
Externí odkaz:
https://doaj.org/article/0503e7da1cca40afa0953e96d2560af7
Autor:
Rebecca Whiteley
Publikováno v:
British Art Studies, Iss 19 (2021)
In 1833, an unusual book was published in London, Edinburgh, and Dublin. Written and illustrated by the surgeon and artist George Spratt, Obstetric Tables stood out among midwifery guides of the period for its coloured lithographic illustrations, mob
Externí odkaz:
https://doaj.org/article/c739f1cc30134b9383230412ec4ec0fb
Autor:
Sarah Ross, Michael Niedbala, Sabina Cosulich, Zoe Underwood, Eleanor Wigmore, Alison Peter, Carla P. Martins, Lukasz Magiera, Jason G. Kettle, Giovanni Ciotta, Ivan del Barco Barrantes, Tamara Baker, James Atkinson, Alex Koers, Rebecca Whiteley, Radoslaw Polanski, Michael Davies, Sue Bickerton, Hilary Lewis, David Robinson, Lyndsey Hanson, Atanu Chakraborty
Supplementary Data from AZD4625 is a Potent and Selective Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af8725b786ab7b470d22cf3bb924324
https://doi.org/10.1158/1535-7163.22523586.v1
https://doi.org/10.1158/1535-7163.22523586.v1
Autor:
Sarah Ross, Michael Niedbala, Sabina Cosulich, Zoe Underwood, Eleanor Wigmore, Alison Peter, Carla P. Martins, Lukasz Magiera, Jason G. Kettle, Giovanni Ciotta, Ivan del Barco Barrantes, Tamara Baker, James Atkinson, Alex Koers, Rebecca Whiteley, Radoslaw Polanski, Michael Davies, Sue Bickerton, Hilary Lewis, David Robinson, Lyndsey Hanson, Atanu Chakraborty
Supplementary Figure from AZD4625 is a Potent and Selective Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040a8dea15a3d11c94aef8426fadb286
https://doi.org/10.1158/1535-7163.22523583
https://doi.org/10.1158/1535-7163.22523583
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Autor:
Rebecca Whiteley
Leading historians, anthropologists, educators and designers explore the role of materiality in medical education. With a broad focus, international scope and experimental format, this is the first book to seriously reflect on the material relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9a842dc307376853e127d0ea38dfd1
Autor:
Atanu Chakraborty, Lyndsey Hanson, David Robinson, Hilary Lewis, Sue Bickerton, Michael Davies, Radoslaw Polanski, Rebecca Whiteley, Alex Koers, James Atkinson, Tamara Baker, Ivan del Barco Barrantes, Giovanni Ciotta, Jason G. Kettle, Lukasz Magiera, Carla P. Martins, Alison Peter, Eleanor Wigmore, Zoe Underwood, Sabina Cosulich, Michael Niedbala, Sarah Ross
Publikováno v:
Molecular cancer therapeutics. 21(10)
AZD4625 is a potent, selective, and orally bioavailable inhibitor of oncogenic KRASG12C as demonstrated in cellular assays and in vivo in preclinical cell line–derived and patient-derived xenograft models. In vitro and cellular assays have shown se
Publikováno v:
Molecular Genetics and Metabolism. 138:107180
Autor:
Rodrigo J. Carbajo, S. Harlfinger, Lyman Feron, Jason Grant Kettle, E.S. Gleave, Hilary J. Lewis, L. Liu, A. Jackson, Doyle Joseph Cassar, Sharanjeet Kaur Bagal, David Robinson, Radoslaw Polanski, L. Zhang, M.R. Howard, Sabina Cosulich, L. Evans, Jason Breed, Graeme R. Robb, A. Chakraborty, Rachel L. Howells, Rebecca Whiteley, Scott G. Lamont, Lyndsey Hanson, J.K. Kingston, Michael Davies, Iain A. Cumming, Sarah Ross, Sue Bickerton, Paul D. Kemmitt, Derek Ogg, Andrew John Eatherton, James M. Smith, S. Li, Bodnarchuk, Frederick W. Goldberg, Christopher R. Phillips, X. Zhao, Jun Yang, Michael Tonge, Shaun M. Fillery
Publikováno v:
Journal of Medicinal Chemistry. 63:4468-4483
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRASG12C mutant represents an "Achilles heel" and has recently yielded to covalent targeting with small mol
Autor:
Jordi Bertrán-Alamillo, John Travers, Sara Talbot, Rebecca Whiteley, Ana Giménez-Capitán, Ruth Román, Sonia Rodríguez, Erika Aldeguer, Josep Castellví, Alejandro Martínez-Bueno, Andrea Martella, Jamal Saeh, Giulia Fabbri, Rafael Rosell, Urszula Polanska, Jelena Urosevic, Miguel A. Molina-Vila
Publikováno v:
Cancer Research. 82:2642-2642
Background: Aurora kinase B (AURKB) plays a key role in the regulation of mitosis, and AURKB inhibitors are in Phase II-III clinical trials. We reported previously that Chr22q11 amplification, leading to BID overexpression, was associated with apopto