Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

Autor: Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi, Mikael Sommarin, Shamit Soneji, Henrik Hjorth-Hansen, Satu Mustjoki, Johan Richter, Ram Krishna Thakur, Göran Karlsson

Publikováno v: eLife, Vol 12 (2024)

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of

Externí odkaz: https://doaj.org/article/d2afc990e3264278aae9d3f9ec4607bc

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy

Autor: Mikael Sommarin, Fatemeh Safi, Konturek-Ciesla A, Parashar Dhapola, Eva Erlandsson, Geironson Ulfsson L, Charlotta Böiers, Rebecca Warfvinge, Göran Karlsson, Krishna Thakur R, David Bryder

The advent of single cell (Sc) genomics has challenged the dogma of haematopoiesis as a tree-like structure of stepwise lineage commitment through distinct and increasingly restricted progenitor populations. Instead, analysis of ScRNA-seq has propose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7efbf6a5703db2c765dd7d7d8fe2263d
https://doi.org/10.1101/2021.04.01.437998

Single-Cell Roadmap of Immune Cell Response in Chronic Myeloid Leukemia

Autor: Jay Klievink, Ulla Olsson-Strömberg, Satu Mustjoki, Mette Ilander, Taina Jaatinen, Rebecca Warfvinge, Harri Lähdesmäki, Henrik Hjorth-Hansen, Shady Adnan Awad, Jani Huuhtanen, Jason Theodoropoulos, Olli Dufva, Göran Karlsson, Anna Kreutzman, Tiina Kasanen, Andreas Burchert

Publikováno v: Blood. 136:4-5

Only half of chronic myeloid leukemia (CML) patients in deep molecular remission are able to maintain treatment free remission (TFR) after tyrosine kinase inhibitor (TKI) discontinuation. Identifying predictive markers for TFR remains a key issue. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffc1579addd0cdaf72d0559219b1bf32
https://doi.org/10.1182/blood-2020-139134

Characterization of Leukemic Stem Cells Heterogeneity in Chronic Myeloid Leukemia

Autor: Ram Krishna Thakur, Parashar Dhapola, Mikael Sommarin, Fatemeh Safi, Ulrich Pfisterer, Rebecca Warfvinge, Johan Richter, Linda Geironson Ulfsson, Göran Karlsson

Publikováno v: Blood. 134:4140-4140

In chronic myeloid leukemia (CML), a rare subset of leukemic stem cells (LSC) persists in patients responding to conventional tyrosine kinase inhibitor (TKI) therapy. The failure to eradicate these LSCs results in indefinite therapy dependence and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85dba1edfa7e8154a50ca0d0adef03f6
https://doi.org/10.1182/blood-2019-130956

Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Autor: Ulla Olsson-Strömberg, Christine Karlsson, Jesper Stentoft, Teona Roschupkina, Göran Karlsson, Leif Stenke, Shamit Soneji, Henrik Hjorth-Hansen, Linda Geironson, Rebecca Warfvinge, Johan Richter, Mikael Sommarin, Stefan Lang, Satu Mustjoki

Publikováno v: Warfvinge, R, Geironson, L, Sommarin, M N E, Lang, S, Karlsson, C, Roschupkina, T, Stenke, L, Stentoft, J, Olsson-Stromberg, U, Hjorth-Hansen, H, Mustjoki, S, Soneji, S, Richter, J & Karlsson, G 2017, ' Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML ', Blood, vol. 129, no. 17, pp. 2384-2394 . https://doi.org/10.1182/blood-2016-07-728873

Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunopheno-typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8068b71a2acb946c4703341d452f453f
https://pubmed.ncbi.nlm.nih.gov/28450572