Výsledky vyhledávání - "Rebecca, L Johnson"

Akademický článek

Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library

Autor: Devan J. Shell, Justin M. Rectenwald, Peter H. Buttery, Rebecca L. Johnson, Caroline A. Foley, Shiva K.R. Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L. Norris-Drouin, Matthew Axtman, P. Brian Hardy, Masoud Vedadi, Stephen V. Frye, Lindsey I. James, Kenneth H. Pearce

Publikováno v: SLAS Discovery, Vol 27, Iss 8, Pp 428-439 (2022)

Methyl-lysine (Kme) reader domains are prevalent in chromatin regulatory proteins which bind post-translational modification sites to recruit repressive and activating factors; therefore, these proteins play crucial roles in cellular signaling and ep

Externí odkaz: https://doaj.org/article/859446a01131470eb8e3880dae7658e0

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Akademický článek

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Autor: Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo

Publikováno v: Gut Microbes, Vol 14, Iss 1 (2022)

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximat

Externí odkaz: https://doaj.org/article/d7e2a86fc68a4383913bdd253fcb47e1

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Akademický článek

Evidence-Based Alignment of Pathology Residency With Practice II: Findings and Implications

Autor: W. Stephen Black-Schaffer MD, Stanley J. Robboy MD, David J. Gross PhD, James M. Crawford MD, PhD, Kristen Johnson PhD, Melissa Austin MD, Donald S. Karcher MD, Rebecca L. Johnson MD, Suzanne Z. Powell MD, Joseph Sanfrancesco MD, Michael B. Cohen MD

Publikováno v: Academic Pathology, Vol 8 (2021)

This article presents findings from a 4-year series of surveys of new-in-practice pathologists, and a survey of physician employers of new pathologists, assessing how pathology graduate medical education prepares its graduates for practice. Using the

Externí odkaz: https://doaj.org/article/27d1cdb74ebf4d4d9a858ab843ec4017

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Akademický článek

Outpatient Dismissal With a Responsible Adult Compared With Structured Solo Dismissal: A Retrospective Case-Control Comparison of Safety Outcomes

Autor: David P. Martin, MD, PhD, Mary E. Warner, MD, Rebecca L. Johnson, MD, Marlea A. Judd, APRN, CRNA, DNP, Michael T. Walsh, MD, Andrew C. Hanson, BS, Darrell R. Schroeder, MS, Christopher M. Burkle, MD, JD

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 2, Iss 3, Pp 234-240 (2018)

Objective: To test the hypothesis that patients dismissed alone in a sedation dismissal process (SDP) have no greater risk of adverse outcome compared with those who were dismissed with a responsible adult. Patients and Methods: We compared 2441 SDP

Externí odkaz: https://doaj.org/article/0643c1d3399c4a59832252e303c99ad7

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Spinal Compared with General Anesthesia in Contemporary Primary Total Hip Arthroplasties

Autor: Aaron R, Owen, Adam W, Amundson, Kristin M, Fruth, Christopher M, Duncan, Hugh M, Smith, Rebecca L, Johnson, Michael J, Taunton, Mark W, Pagnano, Daniel J, Berry, Matthew P, Abdel

Publikováno v: Journal of Bone and Joint Surgery. 104:1542-1547

The specific advantages of spinal anesthesia compared with general anesthesia for primary total hip arthroplasty (THA) remains unknown. Therefore, this study aimed to investigate the pain control, length of stay, and postoperative outcomes associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2324bcce65bd24d0f4f0b5101acf9a2
https://doi.org/10.2106/jbjs.22.00280

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Development of VHL-recruiting STING PROTACs that suppress innate immunity

Autor: Zhichuan Zhu, Rebecca L. Johnson, Zhigang Zhang, Laura E. Herring, Guochun Jiang, Blossom Damania, Lindsey I. James, Pengda Liu

STING acts as a cytosolic nucleotide sensor to trigger host defense upon viral or bacterial infection. While STING hyperactivation can exert anti-tumor effects by increasing T-cell filtrates, in other contexts hyperactivation of STING can contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350d44d1ee52ca813ae603059197804
https://doi.org/10.21203/rs.3.rs-2496673/v1

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