Výsledky vyhledávání - "Rebecca, Humphrey"

Akademický článek

Population pharmacokinetics of molnupiravir in adults with COVID‐19: Lack of clinically important exposure variation across individuals

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1859-1871 (2023)

Abstract Effective antiviral treatments for coronavirus disease 2019 (COVID‐19) are needed to reduce the morbidity and mortality associated with severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection, particularly in patients

Externí odkaz: https://doaj.org/article/8cddadd8bcca434f80fe87480a247f8a

Zobrazit plný text záznamu

Plný text ve formátu HTML

A Model-Based Approach to Bridging Plasma and Dried Blood Spot Concentration Data for Phase 3 Verubecestat Trials

Autor: Marissa F, Dockendorf, David, Jaworowicz, Rebecca, Humphrey, Melanie, Anderson, Sheila, Breidinger, Lei, Ma, Theresa, Taylor, Nicole, Dupre, Christopher, Jones, Christine, Furtek, Bhavna, Kantesaria, Kevin P, Bateman, Eric, Woolf, Michael F, Egan, Julie A, Stone

Publikováno v: The AAPS Journal. 24

In-clinic venous dried blood spot (DBS) pharmacokinetic (PK) sampling was incorporated into two phase 3 studies of verubecestat for Alzheimer's disease (EPOCH [NCT01739348] and APECS [NCT01953601]), as a potential alternative to plasma PK sampling. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6725a0a9e0d19ed66541455c65d683fb
https://doi.org/10.1208/s12248-022-00682-5

Zobrazit plný text záznamu

Population Pharmacokinetic Analysis of the Cathepsin K Inhibitor Odanacatib: Insights Into Intrinsic and Extrinsic Factor Effects on Exposure in Postmenopausal and Elderly Women

Autor: S. Aubrey Stoch, Sébastien Bihorel, Stefan Zajic, David Jaworowicz, Rebecca Humphrey, Jacqueline B. McCrea, Julie A. Stone

Publikováno v: Journal of clinical pharmacologyReferences. 60(8)

This analysis developed a population pharmacokinetic (PK) model for odanacatib, characterized demographic and concomitant medication covariates effect, and provided odanacatib exposure estimates for subjects in phase 2/3 studies. Data from multiple p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386d9a9f163a95d3dc1cf34ff6b44ac9
https://pubmed.ncbi.nlm.nih.gov/32302427

Zobrazit plný text záznamu

P1‐038: VERUBECESTAT PHARMACOKINETIC AND EXPOSURE‐RESPONSE RESULTS FROM EPOCH: A PHASE 3 TRIAL IN MILD‐TO‐MODERATE ALZHEIMER'S DISEASE

Autor: Julie A. Stone, Ming Xu, Mike F. Egan, David J. Jaworowicz, Marissa F. Dockendorf, Rebecca Humphrey, Christian Rasmussen, Tiffini Voss, Huub Jan Kleijn

Publikováno v: Alzheimer's & Dementia. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7afb56482eb16f8239ae72ca9741078f
https://doi.org/10.1016/j.jalz.2018.06.039

Zobrazit plný text záznamu

The influence of ethnicity and gender on navigating an acute coronary syndrome event

Autor: Rebecca Humphrey, Shaminder Singh, Kathryn King-Shier, Nadia A. Khan, Pamela LeBlanc, Hude Quan, Charles M Mather

Publikováno v: European Journal of Cardiovascular Nursing. 14:240-247

Ethnicity and gender may influence acute coronary syndrome patients recognizing symptoms and making the decision to seek care.To examine these potential differences in European (Caucasian), Chinese and South Asian acute coronary syndrome patients.In-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8f46aa8c62ba30ad0fec13252cea18
https://doi.org/10.1177/1474515114529690

Zobrazit plný text záznamu