Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rebeca Fernandez-Ruiz"'
Autor:
Marta Fontcuberta-PiSunyer, Ainhoa García-Alamán, Èlia Prades, Noèlia Téllez, Hugo Alves-Figueiredo, Mireia Ramos-Rodríguez, Carlos Enrich, Rebeca Fernandez-Ruiz, Sara Cervantes, Laura Clua, Javier Ramón-Azcón, Christophe Broca, Anne Wojtusciszyn, Nuria Montserrat, Lorenzo Pasquali, Anna Novials, Joan-Marc Servitja, Josep Vidal, Ramon Gomis, Rosa Gasa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Human foreskin fibroblasts are directly reprogrammed into insulin-producing cells using 5 pancreatic transcription factors, without pluripotency induction.
Externí odkaz:
https://doaj.org/article/29d2817f5dfe44d989d5e0fd8d306fda
Autor:
Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Yaiza Esteban, Joan Mir-Coll, Berta Serra-Navarro, Marta Fontcuberta-PiSunyer, Christophe Broca, Mathieu Armanet, Anne Wojtusciszyn, Vardit Kram, Marian F. Young, Josep Vidal, Ramon Gomis, Rosa Gasa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The proliferation of pancreatic beta cells decreases with age, partly due to systemic changes. Here the authors identify Wisp1 as a circulating factor enriched in young serum that induces adult beta cell proliferation, supporting the idea that young
Externí odkaz:
https://doaj.org/article/75526fb6644249f68e8b4986865a300c
Autor:
Berta Serra-Navarro, Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Yaiza Esteban, Joan Mir-Coll, Julia Mathieu, Stephane Dalle, Max Hahn, Ulf Ahlgren, Lee S. Weinstein, Josep Vidal, Ramon Gomis, Rosa Gasa
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101264- (2021)
Objective: Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the lifetime. β cells are formed from progenitors during embryonic development but unde
Externí odkaz:
https://doaj.org/article/9a142fddcdd54662a98fe0baba8cb82b
Autor:
Gloria Aranda, Cristina Lopez, Rebeca Fernandez-Ruiz, Yaiza Esteban, Guillermo Garcia-Eguren, Mireia Mora, Irene Halperin, Gregori Casals, Joaquim Enseñat, Felicia A. Hanzu
Publikováno v:
International Journal of Endocrinology, Vol 2017 (2017)
Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombo
Externí odkaz:
https://doaj.org/article/d4213fd57ac5495fa0fcc5ec7017e3be
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90344 (2014)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin signalling pathway. It has been demonstrated that PTP1B deletion protects against the development of obesity and Type 2 Diabetes, mainly through its action on peripheral t
Externí odkaz:
https://doaj.org/article/b6fd7ecaee3841f29a85adfd487ecd0c
Autor:
Elaine Vieira, Laura Marroquí, Ana Lucia C Figueroa, Beatriz Merino, Rebeca Fernandez-Ruiz, Angel Nadal, Thomas P Burris, Ramon Gomis, Ivan Quesada
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69939 (2013)
Disruption of pancreatic clock genes impairs pancreatic beta-cell function, leading to the onset of diabetes. Despite the importance of pancreatic alpha-cells in the regulation of glucose homeostasis and in diabetes pathophysiology, nothing is known
Externí odkaz:
https://doaj.org/article/d61b0ca28ca9402ba33044f7fecfda40
Autor:
Rosa Gasa, Anne Wojtusciszyn, Josep Vidal, Sara Cervantes, Laura Clua, Christophe Broca, Javier Ramón-Azcón, Èlia Prades, Rebeca Fernandez-Ruiz, Anna Novials, Carlos Enrich, Hugo Figueiredo, Marta Fontcuberta-PiSunyer, Nuria Montserrat, Ainhoa García-Alamán, Noèlia Téllez, Ramon Gomis
Direct lineage reprogramming of one somatic cell into another bypassing an intermediate pluripotent state has emerged as an alternative to embryonic or induced pluripotent stem cell differentiation to generate clinically relevant cell types. One cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::210730de6c64fa222d45bf9550edadc9
https://doi.org/10.1101/2021.08.05.455196
https://doi.org/10.1101/2021.08.05.455196
Autor:
Marta Fontcuberta-PiSunyer, Rosa Gasa, Josep Vidal, Joan Mir-Coll, Berta Serra-Navarro, Vardit Kram, Yaiza Esteban, Anne Wojtusciszyn, Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Ramon Gomis, Mathieu Pierre Jean Armanet, Marian F. Young, Christophe Broca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 5982
Nature Communications
Nature communications, vol. 11, no. 1, pp. 5982
Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19de8bf767d97537e169cffe69295673
https://doi.org/10.1038/s41467-020-19657-1
https://doi.org/10.1038/s41467-020-19657-1
Autor:
Mercè Obach, Anna Novials, José I. Martín-Subero, Guadalupe Soria, Oscar Yanes, Estrella Sanchez-Rebordelo, Laura Herrero, Joan Vendrell, Pau Gama-Perez, Roger Guimerà, Giancarlo Castellano, Rebeca Fernandez-Ruiz, Sonia Fernández-Veledo, Joan Miró, Rubén Nogueiras, Marta Sales-Pardo, Alba Gonzalez-Franquesa, Sara Samino, Marc Claret, José Antonio Enríquez, Carlos Castaño, Ana Latorre-Pellicer, Marta Kulis, Ignacio Prieto, Jose C. Perales, Pablo M. Garcia-Roves, Lourdes Navarro, Vicente Chapaprieta, Norma Dahdah, Gregor Oemer, Erika Monelli, Mariona Graupera, Markus A. Keller, Joel Montane, Sonia Moreno-Gomez, Marc Schneeberger, Xavier Duran, Angel Carracedo, María Monsalve, Ramon Gomis, Antoni Aguilar-Mogas
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, metabolomic and transcriptomic approach to systematical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18f897ad23eaed73a480ee23664b9a22
https://doi.org/10.1101/2020.07.08.194167
https://doi.org/10.1101/2020.07.08.194167
Autor:
Anne Wojtusciszyn, Rita Malpique, Christophe Broca, Rebeca Fernandez-Ruiz, Ana Lucia C. Figueroa, Ainhoa Garcia, Rosa Gasa, Ramon Gomis, Hugo Figueiredo
Publikováno v:
O2, repositorio institucional de la UOC
Universitat Oberta de Catalunya (UOC)
BASE-Bielefeld Academic Search Engine
Universitat Oberta de Catalunya (UOC)
BASE-Bielefeld Academic Search Engine
Deficient vascularization is a major driver of early islet graft loss and one of the primary reasons for the failure of islet transplantation as a viable treatment for type 1 diabetes. This study identifies the protein tyrosine phosphatase 1B (PTP1B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b332bd550ce3802fb34561c63925bb
https://doi.org/10.1126/scitranslmed.aar6294
https://doi.org/10.1126/scitranslmed.aar6294