Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rebeca, Alba Rubio"'
Autor:
Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 156-162 (2019)
Background: Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This is in part caused by the absence of prognostic biomarkers that can identify high-risk
Externí odkaz:
https://doaj.org/article/519688e9d40c4215ae075d85d43e55cd
Autor:
Shu-Hong Lin, Joshua N Sampson, Thomas G P Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetête-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Udo Kontny, Anna González-Neira, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Perrine Marec Bérard, Jeremy Miller, Neal D Freedman, Nathaniel Rothman, Brian D Carter, Casey L Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G Cox, Robert N Hoover, Javed Khan, Gregory T Armstrong, Wendy M Leisenring, Smita Bhatia, Leslie L Robison, Andreas E Kulozik, Jennifer Kriebel, Thomas Meitinger, Markus Metzler, Manuela Krumbholz, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lisa Mirabello, Margaret A Tucker, Franck Tirode, Lindsay M Morton, Stephen J Chanock, Olivier Delattre, Mitchell J Machiela
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237792 (2020)
BackgroundEwing sarcoma (EwS) is a rare, aggressive solid tumor of childhood, adolescence and young adulthood associated with pathognomonic EWSR1-ETS fusion oncoproteins altering transcriptional regulation. Genome-wide association studies (GWAS) have
Externí odkaz:
https://doaj.org/article/f21a3cae3175421296c803674a427eeb
Autor:
Mitchell J. Machiela, Thomas G. P. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Perrine Marec Bérard, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Andreas E. Kulozik, Jennifer Kriebel, Thomas Meitinger, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate
Externí odkaz:
https://doaj.org/article/0ac8edbb89d948f498acb3404c1156e8
Autor:
Andreas Petry, Rupert Öllinger, Thomas G. P. Grunewald, Stefan Burdach, Gaurav Jain, Davide G. Franchina, Erik Hameister, Agnes Görlach, Poul H. Sorensen, Michaela Carina Baldauf, Juliane Schmäh, Jürgen Ruland, Carolin Prexler, Elmar Wolf, Gunther Richter, Dirk Brenner, Alexandra Sipol, Uwe Thiel, Roland Rad, Gunnar Cario, Maxim Barenboim, Julia Hofstetter, Busheng Xue, Rebeca Alba Rubio
Publikováno v:
Sipol, A, Hameister, E, Xue, B, Hofstetter, J, Barenboim, M, Öllinger, R, Jain, G, Prexler, C, Rubio, R A, Baldauf, M C, Franchina, D G, Petry, A, Schmäh, J, Thiel, U, Görlach, A, Cario, G, Brenner, D, Richter, G H S, Grünewald, T G P, Rad, R, Wolf, E, Ruland, J, Sorensen, P H & Burdach, S E G 2022, ' MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress ', Blood, vol. 139, no. 8, pp. 1184-1197 . https://doi.org/10.1182/blood.2020007932
Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired antimetabolic stress responses to maintain homeosta
Autor:
Sarah-Maria Fendt, Katrien De Bock, Shinya Kuroda, Diego di Bernardo, Diether Lambrechts, Johannes V. Swinnen, Christophe M. Deroose, Chantal Mathieu, Adrian Liston, Thomas G.P. Grünewald, Jos van Pelt, Rebeca Alba Rubio, James Dooley, Jia Zeng, Jonas Dehairs, Joke Van Elsen, Juan Fernandez-Garcia, Roman Vangoitsenhoven, Bryan Holvoet, Miki Eto, Masashi Fujii, Suguru Fujita, Francesco Napolitano, Yasuaki Karasawa, Kim Vriens, Mélanie Planque, Koen Veys, Dorien Broekaert, Roberta Schmieder, João André Gonçalves Duarte, Lindsay A. Broadfield
This document contains supplemental figures 1-7 and detailed supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f44ebc09205b2e32761557565475e6
https://doi.org/10.1158/0008-5472.22430289.v1
https://doi.org/10.1158/0008-5472.22430289.v1
Autor:
Sarah-Maria Fendt, Katrien De Bock, Shinya Kuroda, Diego di Bernardo, Diether Lambrechts, Johannes V. Swinnen, Christophe M. Deroose, Chantal Mathieu, Adrian Liston, Thomas G.P. Grünewald, Jos van Pelt, Rebeca Alba Rubio, James Dooley, Jia Zeng, Jonas Dehairs, Joke Van Elsen, Juan Fernandez-Garcia, Roman Vangoitsenhoven, Bryan Holvoet, Miki Eto, Masashi Fujii, Suguru Fujita, Francesco Napolitano, Yasuaki Karasawa, Kim Vriens, Mélanie Planque, Koen Veys, Dorien Broekaert, Roberta Schmieder, João André Gonçalves Duarte, Lindsay A. Broadfield
Supplemental tables 1-10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73115082b4a3a4a81d0ded6705f5c24e
https://doi.org/10.1158/0008-5472.22430286.v1
https://doi.org/10.1158/0008-5472.22430286.v1
Autor:
Sarah-Maria Fendt, Katrien De Bock, Shinya Kuroda, Diego di Bernardo, Diether Lambrechts, Johannes V. Swinnen, Christophe M. Deroose, Chantal Mathieu, Adrian Liston, Thomas G.P. Grünewald, Jos van Pelt, Rebeca Alba Rubio, James Dooley, Jia Zeng, Jonas Dehairs, Joke Van Elsen, Juan Fernandez-Garcia, Roman Vangoitsenhoven, Bryan Holvoet, Miki Eto, Masashi Fujii, Suguru Fujita, Francesco Napolitano, Yasuaki Karasawa, Kim Vriens, Mélanie Planque, Koen Veys, Dorien Broekaert, Roberta Schmieder, João André Gonçalves Duarte, Lindsay A. Broadfield
Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here, we characterize the metabolic response that high-fat availability elicits in livers before disease development. After a short term on a high-fat diet (HFD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066c5087b982f8287631b91a658df7f4
https://doi.org/10.1158/0008-5472.c.6513585.v1
https://doi.org/10.1158/0008-5472.c.6513585.v1
Autor:
Olivia W. Lee, Calvin Rodrigues, Shu-Hong Lin, Wen Luo, Kristine Jones, Derek W. Brown, Weiyin Zhou, Eric Karlins, Sairah M. Khan, Sylvain Baulande, Virginie Raynal, Didier Surdez, Stephanie Reynaud, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetête, Stelly Ballet, Eve Lapouble, Valérie Laurence, Gaelle Pierron, Nathalie Gaspar, Nadège Corradini, Perrine Marec-Bérard, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Michelle Manning, Kathleen Wyatt, Meredith Yeager, Raj Chari, Wendy M. Leisenring, Andreas E. Kulozik, Jennifer Kriebel, Thomas Meitinger, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Gregory T. Armstrong, Smita Bhatia, Leslie L. Robison, Yutaka Yasui, Laura Romero-Pérez, Wolfgang Hartmann, Markus Metzler, W. Ryan Diver, Adriana Lori, Neal D. Freedman, Robert N. Hoover, Lindsay M. Morton, Stephen J. Chanock, Thomas G.P. Grünewald, Olivier Delattre, Mitchell J. Machiela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f130d0b63d38427a5a265ccc0fc8f83c
https://www.ncbi.nlm.nih.gov/pubmed/36787739
https://www.ncbi.nlm.nih.gov/pubmed/36787739
Autor:
Michaela C. Baldauf, Julia S. Gerke, Andreas Kirschner, Franziska Blaeschke, Manuel Effenberger, Kilian Schober, Rebeca Alba Rubio, Takayuki Kanaseki, Merve M. Kiran, Marlene Dallmayer, Julian Musa, Nurset Akpolat, Ayse N. Akatli, Fernando C. Rosman, Özlem Özen, Shintaro Sugita, Tadashi Hasegawa, Haruhiko Sugimura, Daniel Baumhoer, Maximilian M. L. Knott, Giuseppina Sannino, Aruna Marchetto, Jing Li, Dirk H. Busch, Tobias Feuchtinger, Shunya Ohmura, Martin F. Orth, Uwe Thiel, Thomas Kirchner, Thomas G. P. Grünewald
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable targeted immunotherapy, even of oligo-mutated cancers, which lack neo-antigens generated by
Externí odkaz:
https://doaj.org/article/fe2207c4008c460db2d92b4dc1887c16
Autor:
Andreas Kirschner, Melanie Thiede, Thomas G. P. Grünewald, Rebeca Alba Rubio, Günther H. S. Richter, Thomas Kirchner, Dirk H. Busch, Stefan Burdach, Uwe Thiel
Publikováno v:
OncoImmunology, Vol 6, Iss 2 (2017)
Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF inhibitors, i.e., IGF binding proteins (IGFBPs), thereby setting free IGFs. Th
Externí odkaz:
https://doaj.org/article/d3407d35de154a79b4aacf83f32d4e11