Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Reb J. Russell"'
Autor:
Jun Tian, Lianchun Fan, Tapan K. Das, Giovanni Rizzi, Joon Chong Yee, Reb J. Russell, Kathleen Bierilo
Publikováno v:
Biotechnology Progress. 33:1456-1462
The long journey of developing a drug from initial discovery target identification to regulatory approval often leaves many patients with missed window of opportunities. Both regulatory agencies and biopharmaceutical industry continue to develop crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1820657d0066717388d45a9486cb946b
https://doi.org/10.1002/btpr.2477
https://doi.org/10.1002/btpr.2477
Autor:
Ping Xu, Colleen Sparks, Charo Scott, Colleen Clark, Todd Ryder, Reb J. Russell, Michelle Wang, Jiping Zhou
Publikováno v:
Biotechnology Progress. 33:478-489
Demands for development of biological therapies is rapidly increasing, as is the drive to reduce time to patient. In order to speed up development, the disposable Automated Microscale Bioreactor (Ambr 250) system is increasingly gaining interest due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e3d1b6f0e9049bdcf4d6eecd9d2e744
https://doi.org/10.1002/btpr.2417
https://doi.org/10.1002/btpr.2417
Autor:
Giovanni Rizzi, Michael Aronov, Alexis Cowan, Duncan McVey, Boaz Tirosh, John R. Megill, Charo Scott, Reb J. Russell
Publikováno v:
Biotechnology and Bioengineering. 113:1942-1952
The kinase mTOR operates in two cellular complexes, mTORC1 and mTORC2. mTORC1 adjusts metabolic activity according to external growth conditions and nutrients availability. When conditions are prosperous, mTOR facilitates protein and lipid biosynthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7e0c5ddc018306def98d9e3c55f3ea
https://doi.org/10.1002/bit.25951
https://doi.org/10.1002/bit.25951
Autor:
Rohini Deshpande, Scott Estes, Reb J. Russell, Anthony Lubiniecki, Trent P. Munro, Christopher C. Frye, John C. Joly, Karin Anderson, Tongtong Wang, Kathy Francissen
Publikováno v:
Biologicals. 44:117-122
Recently, several health authorities have requested substantial detail from sponsor firms regarding the practices employed to generate the production cell line for recombinant DNA-(rDNA) derived biopharmaceuticals. Two possible inferences from these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808512693f1e86059daf1805a232f4fb
https://doi.org/10.1016/j.biologicals.2016.01.001
https://doi.org/10.1016/j.biologicals.2016.01.001
Autor:
Reb J. Russell, Lu Wang, Smith Timothy R, Sarah G. Laino, Ji Zheng, Colleen Sparks, Barbara Twarowska, Michelle Wang
Publikováno v:
Biotechnology Progress. 31:1515-1525
This article presents the use of caprylic acid (CA) to precipitate impurities from the protein A capture column elution pool for the purification of monoclonal antibodies (mAbs) with the objective of developing a two chromatography step antibody puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9088c0714a514fb76799a8af3c60d05
https://doi.org/10.1002/btpr.2154
https://doi.org/10.1002/btpr.2154
Autor:
Li Tao, Ming Yao, Jinmei Fu, Tapan K. Das, Mingshe Zhu, Yunping Huang, Jacob Bongers, Reb J. Russell, Richard Ludwig, Li Ma
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
Sequence variants of a monoclonal antibody resulting from incomplete processing of signal peptide were identified and characterized using multiple mass spectrometry platforms and reverse phase chromatography. Detection and quantification of these var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc20f1225605ead1f42439683651790
https://pubmed.ncbi.nlm.nih.gov/29078145
https://pubmed.ncbi.nlm.nih.gov/29078145
Autor:
Adrienne A. Tymiak, Guodong Chen, Roxana E. Iacob, Li Tao, Jingjie Mo, John R. Engen, Reb J. Russell, Hui Wei
Publikováno v:
Drug Discovery Today. 19:95-102
The higher order structure of protein therapeutics can be interrogated with hydrogen/deuterium exchange mass spectrometry (HDX-MS). HDX-MS is now a widely used tool in the structural characterization of protein therapeutics. In this article, HDX-MS b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc84de0c11458bbef6a679f77c9372ff
https://doi.org/10.1016/j.drudis.2013.07.019
https://doi.org/10.1016/j.drudis.2013.07.019
Autor:
Brian W. O’Mara, Reb J. Russell, Sarah G. Laino, Michelle Wang, Hui Cai, Jill Dembecki, Jian Zhang, Colleen Sparks, Neil E. Jaffe, Lu Wang
Publikováno v:
Journal of Chromatography A. 1308:86-95
Cleaning-in-place (CIP) for column chromatography plays an important role in therapeutic protein production. A robust and efficient CIP procedure ensures product quality, improves column life time and reduces the cost of the purification processes, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494347ee0f775ba8d787d361e6085c66
https://doi.org/10.1016/j.chroma.2013.07.096
https://doi.org/10.1016/j.chroma.2013.07.096
Autor:
Li Tao, Zheng Jian Li, Ramji Krishnan, Jinmei Fu, Dan Huang, Jacob Bongers, Yueming Qian, Yunping Huang, Joel Goldstein, Jonathan David Basch, Reb J. Russell, Richard Ludwig, Li You
Publikováno v:
Journal of Chromatography B. 908:1-8
Low levels of alanine to serine sequence variants were identified in an IgG4 monoclonal antibody by ultra/high performance liquid chromatography and tandem mass spectrometry. The levels of the identified sequence variants A183S and A152S, both in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb62c822c473769ef464d32bddce2c6
https://doi.org/10.1016/j.jchromb.2012.09.023
https://doi.org/10.1016/j.jchromb.2012.09.023
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 59:167-172
Tris(2-carboxyethyl)phosphine (TCEP) belongs to the trialkylphosphine class of reducing agents that are widely used in research and industry. In this paper, we discuss a sensitive high-performance liquid chromatography (HPLC) method equipped with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5a86192b2c559f0f6f7572d19b9cf4
https://doi.org/10.1016/j.jpba.2011.09.034
https://doi.org/10.1016/j.jpba.2011.09.034