Výsledky vyhledávání - "Reagan L. Pennock"

Akademický článek

Afferent convergence to a shared population of interneuron AMPA receptors

Autor: Reagan L. Pennock, Luke T. Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I. Wadiche

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of trans

Externí odkaz: https://doaj.org/article/7ae40411316e4b6b8cb2ac22171ce8fa

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Climbing Fiber-Mediated Spillover Transmission to Interneurons Is Regulated by EAAT4

Autor: Linda Overstreet-Wadiche, Izumi Sugihara, Jacques I. Wadiche, Gokulakrishna Banumurthy, Shreya Malhotra, Jada H. Vaden, Reagan L. Pennock

Publikováno v: J Neurosci

Neurotransmitter spillover is a form of communication not readily predicted by anatomical structure. In the cerebellum, glutamate spillover from climbing fibers recruits molecular layer interneurons in the absence of conventional synaptic connections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c4e3f8ded952ca11d36e997e22b5c5
https://pubmed.ncbi.nlm.nih.gov/34400517

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Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse

Autor: Shane T. Hentges, Reagan L. Pennock

Publikováno v: Journal of Neurophysiology. 115:2376-2388

Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b7141954cbd8f81728435ea3724aa7
https://doi.org/10.1152/jn.00535.2015

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Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking

Autor: Diego Krapf, Marissa J. Metz, Reagan L. Pennock, Shane T. Hentges

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports

Agonist binding to the mu opioid receptor (MOR) results in conformational changes that allow recruitment of G-proteins, activation of downstream effectors and eventual desensitization and internalization, all of which could affect receptor mobility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60840456b79c185e6d231c72a3433ffe

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Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ‐opioid receptor

Autor: Reagan L. Pennock, Shane T. Hentges

Publikováno v: The Journal of Physiology. 592:4247-4256

Key points Dynorphin A inhibits anorexigenic hypothalamic proopiomelanocortin neurons by activating a potassium conductance. Although dynorphin A is considered selective for κ-opioid receptors, the present data show that the dynorphin A-induced pota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e2b73772ccd963270d7065382b1b23
https://doi.org/10.1113/jphysiol.2014.275339

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Multiple Inhibitory G-Protein-Coupled Receptors Resist Acute Desensitization in the Presynaptic But Not Postsynaptic Compartments of Neurons

Autor: Matthew S. Dicken, Reagan L. Pennock, Shane T. Hentges

Publikováno v: Journal of Neuroscience. 32:10192-10200

Acute desensitization is a common property of G(i/o)-coupled receptors. Recent data, however, suggest that, unlike μ-opioid receptors (MORs) located somatodendritically in neurons or expressed in heterologous systems, MORs in the presynaptic compart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda0364c1408767c1421c746cee25aaf
https://doi.org/10.1523/jneurosci.1227-12.2012

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Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons

Autor: Reagan L. Pennock, Shane T. Hentges

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(1)

Hypothalamic proopiomelanocortin (POMC) neurons release the endogenous opioid beta-endorphin and POMC neuron activity is inhibited by opioids, leading to the proposal that beta-endorphin acts to provide feedback inhibition. However, both intrinsic pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1076eb46ded353373e388def04f4155
https://pubmed.ncbi.nlm.nih.gov/21209213

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Proopiomelanocortin expression in both GABA and glutamate neurons

Autor: Reagan L. Pennock, Malcolm J. Low, Veronica Otero-Corchon, Connie M. King, Shane T. Hentges

Proopiomelanocortin (POMC) neurons have been intensively studied because of their essential role in regulating energy balance and body weight. Many effects of POMC neurons can be attributed to their release of cognate neuropeptides from secretory gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c5cc4ca21396618076886992c54dba
https://europepmc.org/articles/PMC2785088/

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