Výsledky vyhledávání - "Read R. Taintor"

Determination of Nitrate and Nitrite in Biological Samples Using Bacterial Nitrate Reductase Coupled with the Griess Reaction

Autor: Read R. Taintor, John B. Hibbs, Kenneth S. Boockvar, Donald L. Granger

Publikováno v: Methods. 7:78-83

In this article we discuss methodology for quantitation of nitrite and nitrate, end products of the biological synthesis of nitric oxide from L-arginine. Both nitrite and nitrate can be measured, with accuracy to the low micromolar range, using bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::973d44f4c2a84179e2e3d6915aa771d6
https://doi.org/10.1006/meth.1995.1011

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Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

Autor: C. Kablitz, R. L. Menlove, Read R. Taintor, M. P. McMurry, R. L. Baranowski, Zdenek Vavrin, James P. Kushner, John B. Hibbs, John H. Ward, Christof Westenfelder

An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. High-dose interleukin-2 (IL-2) therapy is known to induce the same cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdb15f8586f42386c5e6ecc3421ec52
https://europepmc.org/articles/PMC442932/

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Activated macrophage conditioned medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism

Autor: Charles J. Parker, Read R. Taintor, Ina J. Amber, Zdenek Vavrin, Barbara B. Johnson, John B. Hibbs

Publikováno v: Journal of leukocyte biology. 49(6)

Conditioned medium (CM) from cultures of cytotoxic activated macrophages causes inhibition of mitochondrial respiration, DNA synthesis, and aconitase activity in murine EMT-6 mammary adenocarcinoma cells by an l-arginine dependent effector mechanism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d194fb2c712ba8a59a77d8e0902fa
https://pubmed.ncbi.nlm.nih.gov/1902865

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Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

Autor: Read R. Taintor, John B. Hibbs, Zdenek Vavrin

Publikováno v: Science. 235:473-476

Previous studies have shown that cytotoxic activated macrophages cause inhibition of DNA synthesis, of mitochondrial respiration, and of aconitase activity in tumor target cells. An L-arginine-dependent biochemical pathway synthesizing L-citrulline a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c2cfdc19aa7dc4868d15657746a6e1
https://doi.org/10.1126/science.2432665

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SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

Autor: Read R. Taintor, Zdenek Vavrin, Ina J. Amber, John B. Hibbs

Publikováno v: Journal of Leukocyte Biology. 44:58-65

Treatment of EMT-6 mammary adenocarcinoma cells with gamma interferon (rMuIFNγ) plus tumor necrosis factor (rMuTNFα) and/or interleukin-1 (rHuIL-1α) causes release of iron-55 label, inhibition of DNA replication, and inhibition of aconitase activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da7090bb4be332830147e68b46bb5cee
https://doi.org/10.1002/jlb.44.1.58

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The L-arginine dependent effector mechanism is induced in murine adenocarcinoma cells by culture supernatant from cytotoxic activated macrophages

Autor: Read R. Taintor, John B. Hibbs, Ina J. Amber, Zdenek Vavrin

Publikováno v: Journal of leukocyte biology. 43(2)

Culture medium conditioned by incubation with murine cytotoxic activated macrophages causes release of iron-55 label from viable murine EMT-6 tumor cells as well as inhibition of DNA replication and aconitase activity. These metabolic changes occur i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca36f3eb008562df6e69becb55e90994
https://pubmed.ncbi.nlm.nih.gov/3422089

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Macrophage tumor killing: influence of the local environment

Autor: John B. Hibbs, Weinberg Jb, Read R. Taintor, Harold A. Chapman

Publikováno v: Science (New York, N.Y.). 197(4300)

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e31bd87a765bb345f2ed49fd55f114b
https://pubmed.ncbi.nlm.nih.gov/327547

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Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration

Autor: James Cook, Donald L. Granger, John B. Hibbs, Read R. Taintor

Publikováno v: The Journal of clinical investigation. 65(2)

Cytotoxic activated macrophages (CM) inhibited the growth of neoplastic L1210 cells in vitro but L1210 cell death was minimal to nonexistent. L1210 cells injured by CM were separated from macrophages and studied in an isolated system. CM-injured L121

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a2cd29e0213f98ac90d92499bc680f
https://pubmed.ncbi.nlm.nih.gov/7356685

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