Zobrazeno 1 - 10
of 2 858
pro vyhledávání: '"RdRp"'
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-20 (2024)
Abstract The COVID-19 pandemic has prompted the medical systems of many countries to develop effective treatments to combat the high rate of infection and death caused by the disease. Within the array of proteins found in SARS-CoV-2, the 3 chymotryps
Externí odkaz:
https://doaj.org/article/2c94fa683ec6427788e32f5725d92d8f
Autor:
Veronika Nemethova, Petra Babiakova, Michal Selc, Kristina Jakic, Lucia Uhelska, Boglarka Teglasova, Peter Makovicky, Andrea Babelova, Filip Razga
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117587- (2024)
The coronavirus pandemic has resulted in over 775 million cases and 7 million deaths worldwide, driving efforts to develop therapeutic strategies to control the viral infection. Therapeutic oligonucleotides have shown promise in treating many patholo
Externí odkaz:
https://doaj.org/article/42db88cd8c684cc384754b7cfd19f795
Autor:
Kannan Raman, Rajagopal Kalirajan, Fahadul Islam, Srikanth Jupudi, Divakar Selvaraj, Gomathi Swaminathan, Laliteshwar Pratap Singh, Ritesh Rana, Shopnil Akash, Md. Rezaul Islam, Firzan Nainu, Talha Bin Emran, Turki M. Dawoud, Mohammed Bourhia, Musaab Dauelbait, Rashu Barua
Publikováno v:
ChemistryOpen, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract In the present work, phytoconstituents from Citrus limon are computationally tested against SARS‐CoV‐2 target protein such as Mpro ‐ (5R82.pdb), Spike ‐ (6YZ5.pdb) &RdRp ‐ (7BTF.pdb) for COVID‐19. Docking was done by glide model,
Externí odkaz:
https://doaj.org/article/5ba4d384037e4eeab8b401e4ea8377ab
Autor:
Farah Nazir, Arnaud John Kombe Kombe, Zunera Khalid, Shaheen Bibi, Hongliang Zhang, Songquan Wu, Tengchuan Jin
Publikováno v:
Molecular and Cellular Probes, Vol 77, Iss , Pp 101973- (2024)
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to wreak havoc across the globe. This sudden and deadly pandemic emphasizes the necessity f
Externí odkaz:
https://doaj.org/article/853e435a0410496ebefc86742439f373
Autor:
Dara A. Tahir, Sehand Arif
Publikováno v:
UHD Journal of Science and Technology, Vol 8, Iss 1, Pp 84-92 (2024)
A significant challenge and threat to public health have been created by the COVID-19 pandemic for the entire global population. The study aimed to compare the SARS-CoV-2 RNA detection capabilities of available primers and probes to identify the most
Externí odkaz:
https://doaj.org/article/56d8163c178c43f1a3911eb55db0c75c
Autor:
Michał Majchrzak, Łukasz Madej, Małgorzata Łysek-Gładysińska, Dorota Zarębska-Michaluk, Katarzyna Zegadło, Anna Dziuba, Katarzyna Nogal-Nowak, Wioleta Kondziołka, Iwona Sufin, Mieczysława Myszona-Tarnowska, Mateusz Jaśkowski, Mateusz Kędzierski, Jadwiga Maciukajć, Jarosław Matykiewicz, Stanisław Głuszek, Wioletta Adamus-Białek
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background The evolution of SARS-CoV-2 has been observed from the very beginning of the fight against COVID-19, some mutations are indicators of potentially dangerous variants of the virus. However, there is no clear association between the
Externí odkaz:
https://doaj.org/article/6212be1439c442cd9484141085145183
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTThe Picornaviridae are a large group of positive-sense, single-stranded RNA viruses, and most research has focused on the Enterovirus genus, given they present a severe health risk to humans. Other picornaviruses, such as foot-and-mouth disea
Externí odkaz:
https://doaj.org/article/4dc45554f5ac4fbab9e0968d223b0fe0
Autor:
Ting Ruan, Zheng-Rui Xiang, Yun-Wu Zhang, Shi-Rui Fan, Juan Ren, Qian Zhao, Xiao-Long Sun, Shi-Li Wu, Li-Li Xu, Miao Qiao, Chen-Xu Jing, Xiao-Jiang Hao, Duo-Zhi Chen
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionCurrently, the development of new antiviral drugs against COVID-19 remains of significant importance. In traditional Chinese medicine, the herb Euphorbia fischeriana Steud is often used for antiviral treatment, yet its therapeutic effect
Externí odkaz:
https://doaj.org/article/a7f1cbd90ce5409081fae224ff5970a8
Autor:
Yingqi Feng
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Zika Virus (ZIKV) is a positive-strand RNA virus that can lead to Guillain-Barré syndrome or encephalitis in some individuals and hence presents a serious public health risk. Since the first outbreak of ZIKV in Brazil in 2015, no effective clinical
Externí odkaz:
https://doaj.org/article/dd53c8079f144ca1a110a86e72e5f2b2
Autor:
Aghnia Nabila Ananda, Triawanti Triawanti, Bambang Setiawan, Annisa Camellia Makati, Jasmine Aisyah Putri, Sentot Joko Raharjo
Publikováno v:
Aspects of Molecular Medicine, Vol 3, Iss , Pp 100032- (2024)
Objective: RNA-dependent RNA polymerase (RdRp) is a protein that is essential in the replication and transcription processes of SARS-CoV-2. RdRp inhibitors must be sought, particularly in the identification of active substances in herbal or human die
Externí odkaz:
https://doaj.org/article/67a2e0e982d94fc99b1fc90ddb4518f9