Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells

Autor: Eric Prossnitz, Quehenberger O, Cg, Cochrane, Rd, Ye

Publikováno v: Europe PubMed Central

Differentiated HL60 cells respond to challenge with ligand by mobilizing intracellular second messengers, resulting in superoxide production, degranulation, and actin polymerization with subsequent chemotaxis and phagocytosis. The functional capabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e62f82454004628f49c1afb6cb158c81
https://pubmed.ncbi.nlm.nih.gov/8228256

Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors

Autor: Quehenberger O, Eric Prossnitz, Sl, Cavanagh, Cg, Cochrane, Rd, Ye

Publikováno v: Europe PubMed Central

Binding of the chemotactic tripeptide fMet-Leu-Phe (fMLP) to its receptor on phagocytes activates these cells through a G protein-coupled pathway. To delineate the structural requirement of the N-formyl peptide receptor (FPR) for ligand binding and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b25fbb05d8744da357f9d878548b8a8
http://europepmc.org/abstract/med/8349692

Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides

Autor: Re, Schreiber, Eric Prossnitz, Rd, Ye, Cg, Cochrane, Gm, Bokoch

Publikováno v: Europe PubMed Central

Chemotactic signaling by the human neutrophil N-formyl peptide receptor requires its association with heterotrimeric G protein. Synthetic peptides and a fusion protein derived from the intracellular regions of the receptor were used to identify sites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::514f7a183f63278f5620c5384c413119
http://europepmc.org/abstract/med/8276814

Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode.

Autor: Liu A; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.; Dongguan Songshan Lake Central Hospital, Dongguan Third People's Hospital, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, China., Liu Y; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Chen G; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Lyu W; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Ye F; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Wang J; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Liao Q; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Zhu L; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Du Y; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Ye RD; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.; The Chinese University of Hong Kong, Shenzhen Futian Biomedical Innovation R&D Center, Shenzhen, China.

Publikováno v: PLoS biology [PLoS Biol] 2024 Oct 28; Vol. 22 (10), pp. e3002838. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state.

Autor: Liu Y; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Liu A; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China; Dongguan Songshan Lake Central Hospital, Dongguan Third People's Hospital, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong 523326, China., Li X; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Liao Q; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Zhang W; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Zhu L; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China. Electronic address: zhulizhe@cuhk.edu.cn., Ye RD; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China; The Chinese University of Hong Kong, Shenzhen Futian Biomedical Innovation R&D Center, Shenzhen, Guangdong 518048, China. Electronic address: richardye@cuhk.edu.cn.

Publikováno v: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114578. Date of Electronic Publication: 2024 Aug 01.