The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor

Autor: Sw, Caughman, Matthias Hentze, Ta, Rouault, Jb, Harford, Rd, Klausner

Publikováno v: EMBL-EBI

Ferritin, a cytoplasmic protein critical in iron metabolism, displays iron-dependent regulation of its biosynthetic rate with no corresponding changes in mRNA levels. An iron-responsive element (IRE) has been identified in the 5'-untranslated region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::220040039698f4c93bb0a24d52e96649
https://pubmed.ncbi.nlm.nih.gov/3198610

Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.

Autor: Shigdel UK; Warp Drive Bio, Inc., Redwood City, CA 94063., Lee SJ; Warp Drive Bio, Inc., Redwood City, CA 94063., Sowa ME; Warp Drive Bio, Inc., Redwood City, CA 94063., Bowman BR; Warp Drive Bio, Inc., Redwood City, CA 94063., Robison K; Warp Drive Bio, Inc., Redwood City, CA 94063., Zhou M; Warp Drive Bio, Inc., Redwood City, CA 94063., Pua KH; Warp Drive Bio, Inc., Redwood City, CA 94063., Stiles DT; Warp Drive Bio, Inc., Redwood City, CA 94063., Blodgett JAV; Warp Drive Bio, Inc., Redwood City, CA 94063., Udwary DW; Warp Drive Bio, Inc., Redwood City, CA 94063., Rajczewski AT; Warp Drive Bio, Inc., Redwood City, CA 94063., Mann AS; Warp Drive Bio, Inc., Redwood City, CA 94063., Mostafavi S; Warp Drive Bio, Inc., Redwood City, CA 94063., Hardy T; Department of Molecular and Cell Biology, University of Leicester, LE1 7RH Leicester, United Kingdom., Arya S; Department of Molecular and Cell Biology, University of Leicester, LE1 7RH Leicester, United Kingdom., Weng Z; Warp Drive Bio, Inc., Redwood City, CA 94063., Stewart M; Warp Drive Bio, Inc., Redwood City, CA 94063., Kenyon K; Warp Drive Bio, Inc., Redwood City, CA 94063., Morgenstern JP; Warp Drive Bio, Inc., Redwood City, CA 94063., Pan E; Warp Drive Bio, Inc., Redwood City, CA 94063., Gray DC; Warp Drive Bio, Inc., Redwood City, CA 94063., Pollock RM; Warp Drive Bio, Inc., Redwood City, CA 94063., Fry AM; Department of Molecular and Cell Biology, University of Leicester, LE1 7RH Leicester, United Kingdom., Klausner RD; Lyell Immunopharma, South San Francisco, CA 94080; klausner.rick@gmail.com gregory_verdine@harvard.edu., Townson SA; Warp Drive Bio, Inc., Redwood City, CA 94063., Verdine GL; Warp Drive Bio, Inc., Redwood City, CA 94063; klausner.rick@gmail.com gregory_verdine@harvard.edu.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 21; Vol. 117 (29), pp. 17195-17203. Date of Electronic Publication: 2020 Jun 30.

Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.

Autor: Riss J; Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. rissjo@mail.nih.gov, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, Bauer K, Vasselli JR, Maranchie JK, Kohn KW, Buetow KH, Linehan WM, Weinstein JN, Lee MP, Klausner RD, Barrett JC

Publikováno v: Cancer research [Cancer Res] 2006 Jul 15; Vol. 66 (14), pp. 7216-24.

Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.

Autor: Maranchie JK; Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA., Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM

Publikováno v: Human mutation [Hum Mutat] 2004 Jan; Vol. 23 (1), pp. 40-6.

Medicine. The need for a global HIV vaccine enterprise.

Autor: Klausner RD; Bill and Melinda Gates Foundation, Seattle, WA 98102, USA., Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN

Publikováno v: Science (New York, N.Y.) [Science] 2003 Jun 27; Vol. 300 (5628), pp. 2036-9.