Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rc3h1 protein, mouse"'
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Autor:
Stephanie L. Edelmann, Laura S. de Jonge, Lisa Kifinger, Wolfgang Wurst, Florian Giesert, Christine Hohn, Naoto Kawakami, Sebastian Theurich, Mingui Fu, Dierk Niessing, Nina Kronbeck, Martin E. Kirmaier, Vigo Heissmeyer, Timsse Raj, Thomas Monecke, Elena S. Davydova, Elaine H. Wong, Stefan Feske, Gesine Behrens, Mariano Gonzalez Pisfil
Publikováno v:
Nat Immunol
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in Roquin-1 or loss of Regnase-1 cause systemic lupus erythematosus-like phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47294afa473dd395ea8a5b1a5695f3
https://europepmc.org/articles/PMC8996344/
https://europepmc.org/articles/PMC8996344/
Autor:
Claudia Lohs, Helmut Blum, Elisabeth Kremmer, Marc Schmidt-Supprian, Wolfgang Wurst, Jessica Zöller, Vigo Heissmeyer, Katharina U. Vogel, Mathias Heikenwalder, Stephanie L. Edelmann, Frauke Neff, Arianna Bertossi, Kai P. Hoefig, Gitta Anne Heinz, Dirk Repsilber, Klaus Heger, Arie Geerlof, Katharina M. Jeltsch, Sebastian C. Warth, Joel A. Schick
Publikováno v:
Immunity; Vol 38
Immunity 38, 655-668 (2013)
Immunity
Immunity 38(4), 655-668 (2013). doi:10.1016/j.immuni.2012.12.004
Immunity 38, 655-668 (2013)
Immunity
Immunity 38(4), 655-668 (2013). doi:10.1016/j.immuni.2012.12.004
The Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases follicular helper T (Tfh) cell numbers and causes lupus-like autoimmune di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88b460a46a5babb101bb12b305c427f
