Zobrazeno 1 - 10
of 584
pro vyhledávání: '"Razvan L"'
Autor:
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle. However, the structural dynamics by which calmod
Externí odkaz:
https://doaj.org/article/7cf35385c2e841cd82d95bed6b88e184
Autor:
Osha Roopnarine, Samantha L. Yuen, Andrew R. Thompson, Lauren N. Roelike, Robyn T. Rebbeck, Philip A. Bidwell, Courtney C. Aldrich, Razvan L. Cornea, David D. Thomas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract We have used FRET-based biosensors in live cells, in a robust high-throughput screening (HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA2a). Ou
Externí odkaz:
https://doaj.org/article/d60af476a07b46be82725dcf9dbef5bf
Autor:
Zhixiang Wang, Zhen Zhang, Ying Feng, Lizza E. L. Hendriks, Razvan L. Miclea, Hester Gietema, Janna Schoenmaekers, Andre Dekker, Leonard Wee, Alberto Traverso
Publikováno v:
European Radiology Experimental, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Background Data shortage is a common challenge in developing computer-aided diagnosis systems. We developed a generative adversarial network (GAN) model to generate synthetic lung lesions mimicking ground glass nodules (GGNs). Methods We use
Externí odkaz:
https://doaj.org/article/e0cf50d997d54f8c81e2bb374ed74cf4
Autor:
Anthony R. Braun, Noah Nathan Kochen, Samantha L. Yuen, Elly E. Liao, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
ASN Neuro, Vol 15 (2023)
There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and oligomerization. Building upon our previous aSyn cellular fluorescence lifetime (FLT)-Förster resonance e
Externí odkaz:
https://doaj.org/article/6a357c5ccafa487bb8bcfca0c180fb4b
Autor:
Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two
Externí odkaz:
https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
Autor:
Sarah E. D. Nelson, Daniel K. Weber, Robyn T. Rebbeck, Razvan L. Cornea, Gianluigi Veglia, David D. Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract We have used NMR and circular dichroism spectroscopy to investigate the structural and dynamic effects of oxidation on calmodulin (CaM), using peroxide and the Met to Gln oximimetic mutations. CaM is a Ca2+-sensitive regulatory protein that
Externí odkaz:
https://doaj.org/article/36f3e28887f142c5b2edc2e310a92fe1
Autor:
Salahuddin, Zohaib, Ibrahim, Abdalla, Kuang, Sheng, Widaatalla, Yousif, Miclea, Razvan L., Morin, Oliver, Behr, Spencer, Kop, Marnix P. M., Marcelissen, Tom, Zondervan, Patricia, Jager, Auke, Lambin, Philippe, Woodruff, Henry C
Routine computed tomography (CT) scans often detect a wide range of renal cysts, some of which may be malignant. Early and precise localization of these cysts can significantly aid quantitative image analysis. Current segmentation methods, however, d
Externí odkaz:
http://arxiv.org/abs/2408.03789
Autor:
Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti, Dawn A. Lowe
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the efficacy of therapeutics fo
Externí odkaz:
https://doaj.org/article/9fc4962558974865bb7abc6a1b44cdbc
Autor:
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103706- (2022)
Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, ar
Externí odkaz:
https://doaj.org/article/94f636ca50da4ffaa3d30ac7bc2841a5
Autor:
Philip A. Bidwell, Samantha L. Yuen, Ji Li, Kaja Berg, Robyn T. Rebbeck, Courtney C. Aldrich, Osha Roopnarine, Razvan L. Cornea, David D. Thomas
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1789 (2022)
The sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a P-type ion pump that transports Ca2+ from the cytosol into the endoplasmic/sarcoplasmic reticulum (ER/SR) in most mammalian cells. It is critically important in muscle, facilitating relaxation an
Externí odkaz:
https://doaj.org/article/47192f46bcf14156bb18b504fe0cd0a8