Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Razq Hakem"'
Autor:
Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I. Extremera, M. Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J. Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F. Lange, Conxi Lázaro, Christopher A. Maxwell, Miquel Angel Pujana
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune pe
Externí odkaz:
https://doaj.org/article/63fe713cc69c441fb5f6ed1eab75272b
Autor:
Carmen Herranz, Francesca Mateo, Alexandra Baiges, Gorka Ruiz de Garibay, Alexandra Junza, Simon R Johnson, Suzanne Miller, Nadia García, Jordi Capellades, Antonio Gómez, August Vidal, Luis Palomero, Roderic Espín, Ana I Extremera, Eline Blommaert, Eva Revilla‐López, Berta Saez, Susana Gómez‐Ollés, Julio Ancochea, Claudia Valenzuela, Tamara Alonso, Piedad Ussetti, Rosalía Laporta, Antoni Xaubet, José A Rodríguez‐Portal, Ana Montes‐Worboys, Carlos Machahua, Jaume Bordas, Javier A Menendez, Josep M Cruzado, Roser Guiteras, Christophe Bontoux, Concettina La Motta, Aleix Noguera‐Castells, Mario Mancino, Enrique Lastra, Raúl Rigo‐Bonnin, Jose C Perales, Francesc Viñals, Alvaro Lahiguera, Xiaohu Zhang, Daniel Cuadras, Coline H M vanMoorsel, Joanne J van derVis, Marian J R Quanjel, Harilaos Filippakis, Razq Hakem, Chiara Gorrini, Marc Ferrer, Aslihan Ugun‐Klusek, Ellen Billett, Elżbieta Radzikowska, Álvaro Casanova, María Molina‐Molina, Antonio Roman, Oscar Yanes, Miquel A Pujana
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Abstract Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment. LAM diagnosis and monitoring can al
Externí odkaz:
https://doaj.org/article/51f572bcdff644bcab3c3cc538fd0d47
Autor:
Luis Palomero, Ivan Galván-Femenía, Rafael de Cid, Roderic Espín, Daniel R. Barnes, CIMBA, Eline Blommaert, Miguel Gil-Gil, Catalina Falo, Agostina Stradella, Dan Ouchi, Albert Roso-Llorach, Concepció Violan, María Peña-Chilet, Joaquín Dopazo, Ana Isabel Extremera, Mar García-Valero, Carmen Herranz, Francesca Mateo, Elisabetta Mereu, Jonathan Beesley, Georgia Chenevix-Trench, Cecilia Roux, Tak Mak, Joan Brunet, Razq Hakem, Chiara Gorrini, Antonis C. Antoniou, Conxi Lázaro, Miquel Angel Pujana
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101296- (2020)
Summary: Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in immune and/or stromal c
Externí odkaz:
https://doaj.org/article/48b5448d3f914e5b93d5435b360411fd
Autor:
Mihael Vucur, Florian Reisinger, Jérémie Gautheron, Joern Janssen, Christoph Roderburg, David Vargas Cardenas, Karina Kreggenwinkel, Christiane Koppe, Linda Hammerich, Razq Hakem, Kristian Unger, Achim Weber, Nikolaus Gassler, Mark Luedde, Norbert Frey, Ulf Peter Neumann, Frank Tacke, Christian Trautwein, Mathias Heikenwalder, Tom Luedde
Publikováno v:
Cell Reports, Vol 4, Iss 4, Pp 776-790 (2013)
For years, the term “apoptosis” was used synonymously with programmed cell death. However, it was recently discovered that receptor interacting protein 3 (RIP3)-dependent “necroptosis” represents an alternative programmed cell death pathway a
Externí odkaz:
https://doaj.org/article/35df7eb8c81f4db5974a67379f35add4
Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Publikováno v:
Oncogene. 40:3001-3014
The principle of synthetic lethality, which refers to the loss of viability resulting from the disruption of two genes, which, individually, do not cause lethality, has become an attractive target approach due to the development and clinical success
Autor:
Karan J. Abraham, Miling Wang, Jack Greenblatt, Lauren A. Ostrowski, Aparna Gorthi, Parasvi S. Patel, Daniel D. De Carvalho, Razq Hakem, Michael Ohh, Roxanne Oshidari, Alexander J.R. Bishop, Violena Pietrobon, Anas Samman, Arash Algouneh, Dorothy Yanling Zhao, Stephen Lee, Michael Bokros, Janet N.Y. Chan, V Talya Yerlici, Rajat Singhania, Brendan C. Dickson, Yupeng Liu, Elva Vidya, Negin Khosraviani, Karim Mekhail
Publikováno v:
Nature
Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the
Autor:
Coline H M van Moorsel, Ana Montes-Worboys, Razq Hakem, E. Ellen Billett, Carmen Herranz, Eline Blommaert, Oscar Yanes, Antonio Roman, Julio Ancochea, Álvaro Casanova, Raúl Rigo-Bonnin, Harilaos Filippakis, Berta Saez, August Vidal, Alexandra Baiges, Antoni Xaubet, Suzanne Miller, Antonio Gomez, Roderic Espín, Joanne J van der Vis, José A Rodríguez-Portal, Chiara Gorrini, Jaume Bordas, Marian J R Quanjel, Aleix Noguera-Castells, Luis Palomero, Eva Revilla-López, Josep M. Cruzado, Xiaohu Zhang, Enrique Lastra, Nadia García, Elżbieta Radzikowska, Marc Ferrer, Simon R. Johnson, Christophe Bontoux, Maria Molina-Molina, Alexandra Junza, Javier A. Menendez, Ana I. Extremera, Piedad Ussetti, Rosalía Laporta, Álvaro Lahiguera, Miquel Angel Pujana, Susana Gómez-Ollés, Daniel Cuadras, Mario Mancino, Claudia Valenzuela, Tamara Alonso, Jose C. Perales, Francesca Mateo, Francesc Viñals, Aslihan Ugun-Klusek, Gorka Ruiz de Garibay, Roser Guiteras, Jordi Capellades, Concettina La Motta, Carlos Machahua
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
EMBO Molecular Medicine
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Scientia
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Dipòsit Digital de la UB
Universidad de Barcelona
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
instname
EMBO Molecular Medicine
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Scientia
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Dipòsit Digital de la UB
Universidad de Barcelona
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment. LAM diagnosis and monitoring can also be cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3528695e98889a787bd38a10b1b3e32
http://hdl.handle.net/10261/265901
http://hdl.handle.net/10261/265901
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Autor:
Neil MacLean, Parasvi S. Patel, Razq Hakem, Grace Egan, Aaron D. Schimmer, Rose Hurren, Veronique Voisin, Geethu E. Thomas
Publikováno v:
Cancer Research. 81:3098-3098
Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML Relapse of acute myeloid leukemia (AML) is common and the main cause of mortality in this disease. Leukemia stem cells (LSCs) contribute to relapse however the mech