Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Razia Tajwar"'
Autor:
Dimitrios Moianos, Maria Makri, Georgia-Myrto Prifti, Aristeidis Chiotellis, Alexandros Pappas, Molly E. Woodson, Razia Tajwar, John E. Tavis, Grigoris Zoidis
Publikováno v:
Molecules, Vol 29, Iss 12, p 2942 (2024)
Hepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication. Inhibition of RNase H activity prevents (+) DNA strand synthesis and r
Externí odkaz:
https://doaj.org/article/92d2fc12da214c62bb8eb197a88cae60
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89156d23a1abf190db4d5cded4cbfccc
https://doi.org/10.1124/jpet.122.233090
https://doi.org/10.1124/jpet.122.233090
Publikováno v:
Protein Science. 31
Hepatitis B virus (HBV) replicates by protein-primed reverse transcription. It chronically infects >250 million people, and the dominant anti-HBV drugs are nucleos(t)ide analogs targeting the viral polymerase (P). P has four domains, the terminal pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3954dae49e83db973b7174216e97b8
https://doi.org/10.1002/pro.4421
https://doi.org/10.1002/pro.4421
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0faf97d820f67e335f0751aa00f39f2
https://doi.org/10.1096/fasebj.2022.36.s1.0r716
https://doi.org/10.1096/fasebj.2022.36.s1.0r716
Publikováno v:
Journal of Biotechnology. 306:118-124
Using multi-step error prone PCR (ep-PCR) of the gene encoding endoglucanase Cel12A (27 kDa) from Thermotoga neapolitana, mutants were obtained with many fold increase in the enzyme activity. The best mutant (C6, N47S/E57 K/ V88A/S157 P/K165 H) obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24781e2387bccc31f1e80583124acd0e
https://doi.org/10.1016/j.jbiotec.2019.09.011
https://doi.org/10.1016/j.jbiotec.2019.09.011
Publikováno v:
The Enzymes. 50
Hepatitis B virus (HBV) is a hepatotropic, partially double-stranded DNA virus that replicates by reverse transcription and is a major cause of chronic liver disease and hepatocellular carcinoma. Reverse transcription is catalyzed by the four-domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2d8434ea12a873065756184d41207f7
https://pubmed.ncbi.nlm.nih.gov/34861937
https://pubmed.ncbi.nlm.nih.gov/34861937
Publikováno v:
Journal of Biological Chemistry. 298:101790
The ribonucleases H (RNases H) of HIV and hepatitis B virus are type 1 RNases H that are promising drug targets because inhibiting their activity blocks viral replication. Eukaryotic ribonuclease H1 (RNase H1) is an essential protein and a probable o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d272477ef1c91aa14ff982bcf0defd
https://doi.org/10.1016/j.jbc.2022.101790
https://doi.org/10.1016/j.jbc.2022.101790
Publikováno v:
Extremophiles. 22:109-119
A novel, family GH10 enzyme, Xyn10B from Acidothermus cellulolyticus 11B was cloned and expressed in Escherichia coli. This enzyme was purified to homogeneity by binding to regenerated amorphous cellulose. It had higher binding on Avicel as compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a362144f2f76d73bc0d5d49d07949f0
https://doi.org/10.1007/s00792-017-0981-8
https://doi.org/10.1007/s00792-017-0981-8
Publikováno v:
Enzyme and Microbial Technology. 106:75-82
Xylanase XynB of the hyperthermophile Thermotoga maritima, which belongs to glycoside hydrolase family 10 (GH10), does not have an associated carbohydrate binding module (CBM) in the native state. CBM6 and CBM22 from a thermophile Clostridium thermoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15f50529c4ddbbd20bc6859fbfc283b
https://doi.org/10.1016/j.enzmictec.2017.07.004
https://doi.org/10.1016/j.enzmictec.2017.07.004