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Akademický článek

Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.

Autor: Pieter J A de Koning, J Alain Kummer, Stefanie A H de Poot, Razi Quadir, Roel Broekhuizen, Anne F McGettrick, Wayne J Higgins, Bart Devreese, D Margaret Worrall, Niels Bovenschen

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e22645 (2011)

Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellul

Externí odkaz: https://doaj.org/article/33f3842d8dc145ba90e0a342d9af5d7d

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Freedom of Expression: Positive or Negative freedom? Helping Understanding the Boundaries of a Cherished Right

Autor: Razi Quadir

Publikováno v: NTKR : Tijdschrift voor Recht en Religie, 2019(1), 31-58. Paris
Quadir, R 2019, ' Freedom of Expression: Positive or Negative Freedom? Helping Understanding the Boundaries of a Cherished Right ', NTKR : Tijdschrift voor Recht en Religie, vol. 2019, no. 1, pp. 31-58 . https://doi.org/10.7590/ntkr_2019_003

Freedom of expression is a key value of a liberal democracy. In the Netherlands, like other democracies, freedom of expression has become a hot topic. Events such as the assassinations of Pim Fortuyn (2002) and Theo van Gogh (2004), the Danish cartoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8264b4f87fcde57e27dd3cbb00453ca1
https://doi.org/10.7590/ntkr_2019_003

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All Human Granzymes Target hnRNP K That Is Essential for Tumor Cell Viability

Autor: Roel Broekhuizen, Robert van Domselaar, Astrid M. van der Made, Niels Bovenschen, Razi Quadir

Publikováno v: Journal of Biological Chemistry. 287:22854-22864

Granule exocytosis by cytotoxic lymphocytes is the key mechanism to eliminate virus-infected cells and tumor cells. These lytic granules contain the pore-forming protein perforin and a set of five serine proteases called granzymes. All human granzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf774aa7a028e44168afa77507e575a
https://doi.org/10.1074/jbc.m112.365692

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Proteomic profiling of the human failing heart after left ventricular assist device support

Autor: Helga Steenbergen-Nakken, Petra van der Weide, Matthijs F.M. van Oosterhout, Jaap R. Lahpor, Razi Quadir, Erica Siera-de Koning, Niels Bovenschen, Roel A. de Weger, Nicolaas de Jonge, Marguerite E.I. Schipper

Publikováno v: The Journal of Heart and Lung Transplantation. 30:497-506

Background Left ventricular assist device (LVAD) support is commonly used in patients with heart failure as a bridge to heart transplantation. Whereas myocardial gene expression profile changes have been well established after LVAD support, the conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca17251c4a0c70ea71d4c1431aef4ea
https://doi.org/10.1016/j.healun.2010.11.011

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Noncytotoxic Inhibition of Cytomegalovirus Replication through NK Cell Protease Granzyme M-Mediated Cleavage of Viral Phosphoprotein 71

Autor: Razi Quadir, Emmanuel J. H. J. Wiertz, J. Alain Kummer, Robert van Domselaar, Niels Bovenschen, Leonne E. Philippen

Publikováno v: The Journal of Immunology. 185:7605-7613

Granzyme M (GrM) is highly expressed in cytotoxic granules of NK cells, which provide the first line of defense against viral pathogens. GrM knockout mice show increased susceptibility toward murine CMV infection. Although GrM is a potent inducer of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f244b95890ae45c272b51ad262504f
https://doi.org/10.4049/jimmunol.1001503

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Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A

Autor: Bart Devreese, Arjan B. Brenkman, Jos Joore, J. Alain Kummer, A. Lotte van den Berg, Razi Quadir, Niels Bovenschen, Isabel Vandenberghe

Publikováno v: Journal of Biological Chemistry. 284:3504-3512

Granzymes are serine proteases stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells. Little is known about the molecular mechanism and function of granzyme (Gr)K. GrK is similar to GrA in that they are t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6065df91deae206aeabe7f28058ba92c
https://doi.org/10.1074/jbc.m806716200

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NK Cell Protease Granzyme M Targets α-Tubulin and Disorganizes the Microtubule Network

Autor: Pieter J.A. de Koning, Roel Broekhuizen, Razi Quadir, Niels Bovenschen, J. Alain Kummer, Christopher J. Froelich, J. Mirjam A. Damen, Monique Slijper

Publikováno v: The Journal of Immunology. 180:8184-8191

Serine protease granzyme M (GrM) is highly expressed in the cytolytic granules of NK cells, which eliminate virus-infected cells and tumor cells. The molecular mechanisms by which GrM induces cell death, however, remain poorly understood. In this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4a588ef3fdf6a72539e28e077fac9b
https://doi.org/10.4049/jimmunol.180.12.8184

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Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death

Autor: Bart Devreese, Razi Quadir, Stefanie A. H. de Poot, D. Margaret Worrall, Anne F. McGettrick, Wayne J. Higgins, Niels Bovenschen, Pieter J.A. de Koning, Roel Broekhuizen, J. Alain Kummer

Publikováno v: PLoS ONE
PLOS ONE
PLoS ONE, Vol 6, Iss 8, p e22645 (2011)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67779b400050f253ee56c119d1f10698
http://europepmc.org/articles/PMC3152296

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Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome

Autor: J. Alain Kummer, Jan T.M. van Gemert, Niels Bovenschen, Marcel G.J. Tilanus, Pieter J.A. de Koning, Ingeborg van der Tweel, Gerrit Jan Hordijk, Wun-Shaing W. Chang, Frank K.J. Leusink, Roel Broekhuizen, Razi Quadir

Publikováno v: International journal of cancer. 125(7)

Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6961b043bfa39967dfa5d9bace83ef57
https://pubmed.ncbi.nlm.nih.gov/19569240

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The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system

Autor: Razi Quadir, Kiki Tesselaar, Pieter J.A. de Koning, Thomas J.H. Volman, J. Alain Kummer, Selcuk Colak, Niels Bovenschen

Publikováno v: Molecular immunology. 47(4)

The cytotoxic serine protease granzyme M (GrM) is one of the five human granzymes, which are mainly expressed by cytotoxic T lymphocytes and/or NK cells. Upon perforin-dependent entry into a target cell, GrM cleaves specific substrates resulting in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37bfef2547f2d90b47ecd78291850bc
https://pubmed.ncbi.nlm.nih.gov/19896187

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