Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Razan Orfali"'
Autor:
Razan Orfali, Ali AlFaiz, Madhawi Alanazi, Rahaf Alabdulsalam, Meaad Alharbi, Yara Alromaih, Ismail Dallak, Marah Alrahal, Abdulaziz Alwatban, Reem Saud
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10551 (2024)
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective chloride ion channels. This leads to thick, dehydrated mucus that severely disrupts mucocili
Externí odkaz:
https://doaj.org/article/3909d7d5fe054ca89e0e329a74c52fdd
Autor:
Razan Orfali, Adnan Z. Alwatban, Rawan S. Orfali, Liz Lau, Noble Chea, Abdullah M. Alotaibi, Young-Woo Nam, Miao Zhang
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Numerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of ion channels. Abundant neurodegenerative diseases associated with oxidati
Externí odkaz:
https://doaj.org/article/85654e456eb44bdfb49e1e9b7ed78ffe
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1780 (2023)
K+ channels are involved in many critical functions in lung physiology. Recently, the family of Ca2+-activated K+ channels (KCa) has received more attention, and a massive amount of effort has been devoted to developing selective medications targetin
Externí odkaz:
https://doaj.org/article/3c020c35823c4a62aa96542fbdbe1ffb
Autor:
Razan Orfali, Nora Albanyan
Publikováno v:
Molecules, Vol 28, Iss 2, p 885 (2023)
The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activ
Externí odkaz:
https://doaj.org/article/bbf9239a73a24a4687b9103372cd1b7b
Autor:
Haya I. Aljohar, Hadir M. Maher, Jawza Albaqami, Maha Al-Mehaizie, Rawan Orfali, Razan Orfali, Sarah Alrubia
Publikováno v:
Saudi Pharmaceutical Journal, Vol 26, Iss 7, Pp 932-942 (2018)
Honey is becoming accepted as a reputable and effective therapeutic agent by practitioners of conventional medicine and by the general public. It has many biological activities and has been effectively used in the treatment of many diseases, e.g. gas
Externí odkaz:
https://doaj.org/article/82b677ae21ea4e0bb768e2c88ec9940c
Autor:
Young-Woo Nam, Saba N. Baskoylu, Dimitris Gazgalis, Razan Orfali, Meng Cui, Anne C. Hart, Miao Zhang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Small-conductance Ca2+-activated K+ (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral
Externí odkaz:
https://doaj.org/article/01669cd7d6464d5bb3daf5452d2e06a8
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C658-C664
Small-conductance Ca2+-activated potassium channels subtype 2 (KCa2.2, also called SK2) are operated exclusively by a Ca2+-calmodulin gating mechanism. Heterozygous genetic mutations of KCa2.2 channels have been associated with autosomal dominant neu
Autor:
Young-Woo Nam, Rajasekharreddy Pala, Naglaa Salem El-Sayed, Denisse Larin-Henriquez, Farideh Amirrad, Grace Yang, Mohammad Asikur Rahman, Razan Orfali, Myles Downey, Keykavous Parang, Surya M. Nauli, Miao Zhang
Publikováno v:
ACS Chemical Biology. 17:2344-2354
Autor:
Mohammad Asikur Rahman, Grace Yang, Judy Lee, Misa Nguyen, Young-Woo Nam, Meng Cui, Miao Zhang, Razan Orfali, Naglaa Salem El-Sayed
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: In the activated state of small-conductance Ca(2+)-activated potassium (K(Ca) 2) channels, calmodulin interacts with the HA/HB helices and the S4-S5 linker. CyPPA potentiates K(Ca) 2.2a and K(Ca) 2.3 channel activity but not t
Publikováno v:
Cureus.
Background In palliative care, therapeutic benefit and desired health outcome might be affected by non-adherence to medications, especially among patients with advanced illnesses, such as cancer. The consequences of non-adherence to medications could