Výsledky vyhledávání - "Raza S. Zaheer"

Akademický článek

Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation.

Autor: Michael S Dicay, Christina L Hirota, Natalie J Ronaghan, Michael A Peplowski, Raza S Zaheer, Colin A Carati, Wallace K MacNaughton

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118713 (2015)

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of t

Externí odkaz: https://doaj.org/article/251e6b2b55614eaf967adcfc3e5514f0

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Akademický článek

Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes.

Autor: David Proud, Magdalena H Hudy, Shahina Wiehler, Raza S Zaheer, Minaa A Amin, Jonathan B Pelikan, Claire E Tacon, Tabitha O Tonsaker, Brandie L Walker, Cora Kooi, Suzanne L Traves, Richard Leigh

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40762 (2012)

Human rhinovirus (HRV) infections trigger acute exacerbations of chronic obstructive pulmonary disease (COPD) and asthma. The human airway epithelial cell is the primary site of HRV infection and responds to infection with altered expression of multi

Externí odkaz: https://doaj.org/article/7d437a8870424a809de34846b6cb4dea

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The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

Autor: Raza S. Zaheer, Jerrold R. Turner, Natalie Ronaghan, Pina Colarusso, Richard Leduc, Wallace K. MacNaughton, Judie Shang, Antoine Désilets, Vadim Iablokov, Sébastien P. Dion

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G466-G479

Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63efc14b2540b2a5dd50998e3379bf3f
https://doi.org/10.1152/ajpgi.00441.2015

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Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain

Autor: Natalie Ronaghan, Michael G. Surrette, Mark G. Swain, Raza S. Zaheer, Michael Dicay, Charlotte D'Mello, Tai Le, Wallace K. MacNaughton

Publikováno v: Journal of Neuroscience. 35:10821-10830

Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that arise from changes in brain function. The microbiota-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94daf51f5a1163843bb2f62c74f409b0
https://doi.org/10.1523/jneurosci.0575-15.2015

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Tumor necrosis factor

Autor: Michael A, Peplowski, Andrew J, Vegso, Vadim, Iablokov, Michael, Dicay, Raza S, Zaheer, Bernard, Renaux, David, Proud, Morley D, Hollenberg, Paul L, Beck, Wallace K, MacNaughton

Publikováno v: Physiological Reports

Inflammatory diseases of the gut are associated with altered electrolyte and water transport, leading to the development of diarrhea. Epithelially expressed aquaporins (AQPs) are downregulated in inflammation, although the mechanisms involved are not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ff1bf21c4492f52de0b7e3c179d7b2a
https://pubmed.ncbi.nlm.nih.gov/29038361

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Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity

Autor: Shahina Wiehler, Jonathan B. Pelikan, Suzanne L. Traves, David Proud, Raza S. Zaheer, Richard Leigh, Magdalena H. Hudy

Publikováno v: Mucosal Immunology

Human rhinovirus (HRV) infections trigger exacerbations of lower airway diseases. HRV infects human airway epithelial cells and induces proinflammatory and antiviral molecules that regulate the response to HRV infection. Interferon (IFN)-stimulated g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edff81cba54a0569e369de38361a7896
http://europepmc.org/articles/PMC4137743

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Human Rhinovirus–Induced Epithelial Production of CXCL10 Is Dependent upon IFN Regulatory Factor-1

Autor: David Proud, Raza S. Zaheer

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 43:413-421

Human rhinovirus (HRV) infections are associated with exacerbations of lower-airway diseases. HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7232a1ff579821a68bf5f4a254d26e8
https://doi.org/10.1165/rcmb.2009-0203oc

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Mechanisms of human complement factor B induction in sepsis and inhibition by activated protein C

Autor: Kim Goring, Yong Huang, Dereck Mok, David A. Zygun, Connie Mowat, Raza S. Zaheer, Caroline Léger, Brent W. Winston, Lee Anne Tibbles, Teik-How Lim

Publikováno v: American Journal of Physiology-Cell Physiology. 296:C1140-C1150

To investigate the potential role of the local expression of alternative complement factor B (hBf) in human sepsis, we examined the induction of Bf gene expression in human peripheral blood monocytes (PBMCs) from patients with septic shock and the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f9fe97abf76115847092393e68f9d0
https://doi.org/10.1152/ajpcell.00071.2009

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Selective Transcriptional Down-Regulation of Human Rhinovirus-Induced Production of CXCL10 from Airway Epithelial Cells via the MEK1 Pathway

Autor: Raza S. Zaheer, Neil S. Holden, David Proud, Shahina Wiehler, Rommy Koetzler

Publikováno v: The Journal of Immunology. 182:4854-4864

Human rhinovirus (HRV) infections can trigger exacerbations of lower airway diseases. Infection of airway epithelial cells induces production of a number of proinflammatory chemokines that may exacerbate airway inflammation, including CXCL10, a chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da8a43d76225007f204171f80c42e4a
https://doi.org/10.4049/jimmunol.0802401

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