An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens

Autor: Sobas, Marta, Montesinos, Pau, Boluda, Blanca, Bernal, Teresa, Vellenga, Edo, Nomdedeu, Josep, Gonzalez-Campos, Jose, Chillon, Maria, Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, David Gonzalez-Sanmiguel, Jose, Gil-Cortes, Cristina, Tormo, M., Salamero, Olga, Manso, Felix, Fernandez, Isolda, de la Serna, Javier, Moreno, Maria-Jose, Perez-Encinas, Manuel, Krsnik, Isabel, Ribera, Josep-Maria, Escoda, Lourdes, Lowenberg, Bob, Angel Sanz, Miguel, Beltran de Heredia, J. M., Hernandez, J. M., Arias, J., Ramos, F., Roman, A., de la Serna, J., Negri, S., Rayon, C., Esteve, J., Fernandez-Calvo, F. J., Diaz-Mediavilla, J., Gil, C., Olave, M., Amutio, E., Pedro, C., Gorosquieta, A., Viguria, M., Zudaire, M., Molero, T., Sayas, M. J., Guardia, R., Martinez, J., de Groot, M. R., Schouten, H. C.

Publikováno v: Leukemia & Lymphoma, 60(4), 1030-1035. Informa Healthcare
Leukemia & Lymphoma, 60(4), 1030-1035. TAYLOR & FRANCIS LTD
Leukemia & Lymphoma, 60(4), 1030-1035. Routledge/Taylor & Francis Group

Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26d6ea0c5ac2a5fd762ec0e75545aec
https://doi.org/10.1080/10428194.2018.1516875

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Autor: Labrador J, Luno E, Vellenga E, Brunet S, Gonzalez-Campose J, Chillon M, Holowiecka A, Esteve J, Bergua J, Gonzalez-Sanmiguel J, Gil C, Tormo M, Salamero O, Manso F, Fernandez I, de laSerna J, Moreno M, Perez-Encinas M, Krsnik I, Ribera J, Cervera J, Calasanz M, Boluda B, Sobas M, Lowenberg B, Sanz M, Montesinos P, Palmer L, Ciarlo S, Bezares F, Rojas F, Longoni H, Gelemur M, Fazio P, Canepa C, Saba S, Balladares G, Negri P, Giunta M, Milone J, Prates M, Lafalse D, Sossa C, Jaramillo F, Mayer J, Protivankova M, Scwarz J, Holowiecka-Goral A, Jakubas B, Skret-Norwicz A, Bizgalska-Skrzypek P, Pluta A, Becht R, Kielbinski M, Watek M, Paluszewska M, Gadomska A, Rzenno E, Piszcz J, Ejduk A, Dobrzanska J, Calbecka M, Kostyra A, Malek M, Grosicki S, Knopinska W, Beltran de Heredia J, Hernandez J, Arias J, Ramos F, Roman A, de la Serna J, Negri S, Rayon C, Fernandez-Calvo F, Diaz-Mediavilla J, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas M, Guardia R, Rivas C, Esquembre C, Garcia R, Alcala A, Lopez J, Rubio V, Amigo M, Linares M, Gonzalez San Miguel J, Deben G, Escoda L, de la Camara R, Molines A, Loureiro C, Allegue M, Amador L, Marti J, Madero L, Lassaletta A, Cabezudo M, Garcia-Larana J, Rojas R, Ortega F, Penarrubia M, Puente F, Lopez-Ibor B, Ibanez J, Sanchez P, Novo A, Font L, Guinea J, Montero A, Gonzalez M, Martin G, Martinez J, Verdeguer A, Garcia P, Conde E, Garcia J, Capote F, Bueno J, Bastida P, Rubio A, Fuster J, Gonzalez J, Perez I, Molina J, Mateos M, Ardaiz M, Rodriguez-calvillo M, Poderos C, Arnan M, Duarte R, Diaz-Morfa M, Martin-Chacon E, Calvo-Villas J, Garcia-Belmonte D, Hernandez-Maraver D, Ossenkoppele G, van der Lelie J, Sonneveld P, Zijlmans M, Maertens J, de Valk B, Wijermans P, de Groot M, Schouten H, Biesma D, Kooy M, de Lisa E, PETHEMA Grp, HOVON Grp, PALG Grp, GATLA Grp

Publikováno v: Leukemia & lymphoma
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
LEUKEMIA & LYMPHOMA
r-FISABIO. Repositorio Institucional de Producción Científica
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Leukemia & Lymphoma
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia

Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4d8f98dfbba4745776336cc5815100f5
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=10070

VALIDATION OF PRECISION MEDICINE TEST FOR ACUTE MYELOID LEUKEMIA IN AN OBSERVATIONAL CLINICAL TRIAL

Autor: Montesinos, P., Ballesteros, J., Martinez Cuadron, D., Joaquin Martinez-Lopez, Serrano, J., Perez Oteyza, J., Bergua, J., Tormo, M., Fernandez, P., Vidriales, M. B., Vives, S., Rodriguez-Macias, G., Herrera, P., Garcia, R., Fernandez, M. A., Lavilla, E., Perez Simon, J. A., Jimenez, S., Simiele, A., Gonzalez, A., Gonzalez, B., Burgaleta, C., Hernandez Rivas, J. A., Colorado, M., Sierra, J., Alonso, A., Bethancourt, C., Vera, J. A., Lopez, J. A., Bautista, G., Navas, B., Amador, M. L., Mora Casado, M. A., La Fuente, A., Ramos, F., Cervero, C. J., Rayon, C., Lopez, A., Marti, E., Salamero, O., Olave, T., Gorrochategui, J., Rojas, J. L., Gomez, C., Hernandez, P., Robles, A., Villoria, J., Moscardo, F., Troconiz, I., Sanz, M. A.

Publikováno v: Haematologica
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Web of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b4969ffc5301dcdaddbb08b87f64265f
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6681

Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

Autor: Sanz, M.A., Montesinos, P., Rayon, C., Holowiecka, A., de la Serna, J., Milone, G., de Lisa, E., Brunet, S., Rubio, V., Ribera, J.M., Rivas, C, Krsnik, I., Bergua, J., Gonzalez, J., Diaz-Mediavilla, J., Rojas, R., Manso, F., Ossenkoppele, G.J., Gonzalez, J.D., Lowenberg, B., Pethema, G., Hovon, G.

Publikováno v: BLOOD
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Sanz, M A, Montesinos, P, Rayon, C, Holowiecka, A, de la Serna, J, Milone, G, de Lisa, E, Brunet, S, Rubio, V, Ribera, J M, Rivas, C, Krsnik, I, Bergua, J, Gonzalez, J, Diaz-Mediavilla, J, Rojas, R, Manso, F, Ossenkoppele, G J, Gonzalez, J D, Lowenberg, B, Pethema, G & Hovon, G 2010, ' Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome ', Blood, vol. 115, no. 25, pp. 5137-5146 . https://doi.org/10.1182/blood-2010-01-266007
Blood, 115(25), 5137-5146. American Society of Hematology
Blood
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

A risk-adapted strategy based on all-trans retinoic acid (ATRA) and anthracycline monochemotherapy (PETHEMALPA99 trial) has demonstrated a high antileukemic efficacy in acute promyelocytic leukemia. We designed a new trial (LPA2005) with the objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f1b4a8b486e5959aca3045099dce24
https://doi.org/10.1182/blood-2010-01-266007

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