Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rayomand H. Gimi"'
Autor:
Michael R. Reardon, Edward R. Lee, Vitaly Nivorozhkin, Lynne Sole, Jin Zhao, Craig Siegel, Sanjeev S. Katti, Paul A. Konowicz, Rayomand H. Gimi, Jerome Green
Publikováno v:
Organic Process Research & Development. 19:576-581
A small molecule was under investigation as an inhibitor of glucosylceramide synthase (GCS) for potential use in Fabry disease. To support preclinical activities, a four-step synthesis was developed and used to prepared kilogram quantities of the dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bcc128919c579eda4090ec1d13b603c
https://doi.org/10.1021/op500379a
https://doi.org/10.1021/op500379a
Autor:
Paula Pera, John C. Slater, Scott D. Kuduk, Craig S. Takeuchi, Young Hoon Park, Ralph J. Bernacki, Rayomand H. Gimi, Chung-Ming Sun, Jean Veith, Iwao Ojima
Publikováno v:
Journal of Medicinal Chemistry. 40:267-278
A series of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III was synthesized by means of the beta-lactam synthon method. Most of the new taxoids thus synthesized possess excellent cytotoxicity against human ovarian (A121), non-small-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592c095136d1674e901557b56110eec
https://doi.org/10.1021/jm960563e
https://doi.org/10.1021/jm960563e
Publikováno v:
Tetrahedron. 52:209-224
A series of new fluorine-containing analogs of paclitaxel and docetaxel are synthesized using the coupling of (3R,4S)-1-acyl-β-lactams with high enantiomeric purity with properly protected baccatin III, 10-deacetylbaccatin III, and 14β-hydroxy-10-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca77d93449f50242b6a9d968626fb9a
https://doi.org/10.1016/0040-4020(95)00865-6
https://doi.org/10.1016/0040-4020(95)00865-6
Autor:
John T. Welch, Livia B. Gregor, Michael H. Cynamon, Rayomand H. Gimi, Kathryn E. Bergmann, Cindy A. Sharpe, Radha Rapolu, Hye Jung Han, Gregorio Luciano, Ferenc Gyenes
Publikováno v:
Journal of Medicinal Chemistry. 38:3902-3907
A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eac85c4c6ef44980ee28a655cbd7b9
https://doi.org/10.1021/jm00020a003
https://doi.org/10.1021/jm00020a003
Autor:
Yang Wu, Rayomand H. Gimi, Bart De Corte, Robert E. Handschumacher, Livia G. Boros, John T. Welch
Publikováno v:
Tetrahedron Letters. 35:6033-6036
Fluoroolefin dipeptide isosteres were synthesized applying the Peterson reaction as a novel method for fluoroolefination. The dipeptide isosteres were elaborated to provide the conformationally constrained analogs ( 1 -( R ), 1 -( S ) and 2 -( R ), 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4859fa1973b9a37123ad8dad7f8b39ef
https://doi.org/10.1016/0040-4039(94)88067-0
https://doi.org/10.1016/0040-4039(94)88067-0
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117588b783346f7d5a54fe45e95bb258
https://doi.org/10.1002/chin.199211158
https://doi.org/10.1002/chin.199211158
Publikováno v:
ChemInform. 23
Optically active monofluorinated amides were prepared via the amide acetal Claisen rearrangement and the establishment of the absolute stereochemistry of the rearranged products proved that the chiral auxiliary directed the approach of the crotyl fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b77c5e6e8e511b85b97e391b547389f
https://doi.org/10.1002/chin.199220156
https://doi.org/10.1002/chin.199220156
Autor:
Hye Jung Han, Michael H. Cynamon, Kathryn E. Bergmann, John T. Welch, Livia B. Gregor, Cindy A. Sharpe, Gregorio Luciano, Rayomand H. Gimi, Radha Rapolu, Ferenc Gyenes
Publikováno v:
ChemInform. 27
A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcdc583a4e783084964ca130a16b1c80
https://doi.org/10.1002/chin.199604183
https://doi.org/10.1002/chin.199604183
Publikováno v:
Journal of Medicinal Chemistry. 35:1212-1215
A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity. Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d82165b6a4b32480f7396f429b81c7
https://doi.org/10.1021/jm00085a007
https://doi.org/10.1021/jm00085a007
Publikováno v:
Tetrahedron Letters. 32:4267-4270
Optically active monofluorinated amides were prepared via the amide acetal Claisen rearrangement and the establishment of the absolute stereochemistry of the rearranged products proved that the chiral auxiliary directed the approach of the crotyl fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a8772b6b1a3cde9197b8842bf80576
https://doi.org/10.1016/s0040-4039(00)92145-2
https://doi.org/10.1016/s0040-4039(00)92145-2