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Aging increases cell-to-cell transcriptional variability upon immune stimulation

Autor: Martinez-Jimenez, CP, Eling, N, Chen, H-C, Vallejos, CA, Kolodziejczyk, AA, Connor, F, Stojic, L, Rayner, TF, Stubbington, MJT, Teichmann, SA, De La Roche, M, Marioni, JC, Odom, DT

Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA sequencing of unstimulated and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29047b5d9ddc4e80cd30646afd61e436

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Pervasive lesion segregation shapes cancer genome evolution.

Autor: Aitken SJ; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Anderson CJ; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Connor F; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Pich O; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Sundaram V; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Feig C; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Rayner TF; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Lukk M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Aitken S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Luft J; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Kentepozidou E; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Arnedo-Pac C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Beentjes SV; School of Mathematics and Maxwell Institute, University of Edinburgh, Edinburgh, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Drews RM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Ewing A; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Kaiser VB; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Khamseh A; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Higgs Centre for Theoretical Physics, University of Edinburgh, Edinburgh, UK., López-Arribillaga E; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Redmond AM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Santoyo-Lopez J; Edinburgh Genomics (Clinical), The University of Edinburgh, Edinburgh, UK., Sentís I; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Talmane L; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Yates AD; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Semple CA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., López-Bigas N; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Flicek P; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Odom DT; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. Duncan.Odom@cruk.cam.ac.uk.; German Cancer Research Center (DKFZ), Division of Regulatory Genomics and Cancer Evolution, Heidelberg, Germany. Duncan.Odom@cruk.cam.ac.uk., Taylor MS; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. martin.taylor@igmm.ed.ac.uk.

Publikováno v: Nature [Nature] 2020 Jul; Vol. 583 (7815), pp. 265-270. Date of Electronic Publication: 2020 Jun 24.

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.

Autor: Wong ES; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK., Schmitt BM; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Kazachenka A; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK., Thybert D; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK., Redmond A; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Connor F; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Rayner TF; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Feig C; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Ferguson-Smith AC; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK., Marioni JC; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK., Odom DT; University of Cambridge, Cancer Research UK-Cambridge Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK. duncan.odom@cruk.cam.ac.uk.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. duncan.odom@cruk.cam.ac.uk., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. flicek@ebi.ac.uk.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. flicek@ebi.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2017 Oct 23; Vol. 8 (1), pp. 1092. Date of Electronic Publication: 2017 Oct 23.