Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Raynard L. Bateman"'
Publikováno v:
Journal of Biological Chemistry. 283:35756-35762
Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f3e6adf39000aeacd9384c3e753ccc
https://doi.org/10.1074/jbc.m807125200
https://doi.org/10.1074/jbc.m807125200
Autor:
David E. Timm, Ronald W. McClard, Thomas D. Hurley, Markus Grompe, Raynard L. Bateman, L.-J. Baker, John F. Witte, Justin Ashworth, Pullooru Bhanumoorthy
Publikováno v:
Biochemical Journal. 402:251-260
FAH (fumarylacetoacetate hydrolase) catalyses the final step of tyrosine catabolism to produce fumarate and acetoacetate. HT1 (hereditary tyrosinaemia type 1) results from deficiency of this enzyme. Previously, we prepared a partial mimic of the puta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b37ffbe71334da191b79933cdbf3a7
https://doi.org/10.1042/bj20060961
https://doi.org/10.1042/bj20060961
Autor:
Evangelos Hytopoulos, Eric J. Kunkel, Eugene C. Butcher, Dat Nguyen, Anthony C. Bishop, Ivan Plavec, Raynard L. Bateman, Leon T. Kao, Yuker Wang, Elen S. Rosler, Jennifer Melrose, Kevan M. Shokat, Ellen L. Berg
Publikováno v:
ASSAY and Drug Development Technologies. 2:431-442
Rapid, quantitative methods for characterizing the biological activities of kinase inhibitors in complex human cell systems could allow the biological consequences of differential target selectivity to be monitored early in development, improving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcefb45349a68522e18f3523fdb4f76
https://doi.org/10.1089/adt.2004.2.431
https://doi.org/10.1089/adt.2004.2.431
Autor:
Meenakshi Noll, Keany Rathbun, Carol Reifsteck, Timothy Lax, Milton J. Finegold, Markus Grompe, Susan B. Olson, Kevin P. Battaile, Grover C. Bagby, Raynard L. Bateman
Publikováno v:
Experimental Hematology. 30:679-688
Objective Fanconi anemia (FA) is a genetically heterogeneous disorder associated with defects in at least eight genes. The biochemical function(s) of the FA proteins are unknown, but together they define the FA pathway, which is involved in cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb9c36ddb0e06d8711a7b1755ba0c33
https://doi.org/10.1016/s0301-472x(02)00838-x
https://doi.org/10.1016/s0301-472x(02)00838-x
Publikováno v:
Molecular Therapy. 3(1):14-23
Fanconi anemia (FA) is an autosomal recessive disorder characterized by birth defects, increased incidence of malignancy, progressive bone marrow failure, and cellular hypersensitivity to DNA cross-linking agents. Bone marrow transplantation is thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9687025c0f68251822f3b7fd0ee3114c
Publikováno v:
Molecular and Cellular Biology. 20:8283-8289
Following introduction of DNA interstrand cross-links (ICLs), mammalian cells display chromosome breakage or cell cycle delay with a 4N DNA content. To further understand the nature of the delay, previously described as a G(2)/M arrest, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcec568f58a10756b837ed45bbb65b56
https://doi.org/10.1128/mcb.20.21.8283-8289.2000
https://doi.org/10.1128/mcb.20.21.8283-8289.2000
Autor:
Kevin P. Battaile, Raynard L. Bateman, Derik Mortimer, Jean Mulcahy, R. Keaney Rathbun, Grover Bagby, William H. Fleming, Markus Grompe
Publikováno v:
Blood. 94:2151-2158
Fanconi anemia (FA) is an autosomal recessive disorder characterized by birth defects, increased incidence of malignancy, and progressive bone marrow failure. Bone marrow transplantation is therapeutic and, therefore, FA is a candidate disease for he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52ed3667a361d2d8f994759871c9adf
https://doi.org/10.1182/blood.v94.6.2151.418a22_2151_2158
https://doi.org/10.1182/blood.v94.6.2151.418a22_2151_2158
Autor:
Raynard L. Bateman, William H. Fleming, R. Keaney Rathbun, Markus Grompe, Kevin P. Battaile, Grover C. Bagby, Jean Mulcahy, Derik Mortimer
Publikováno v:
Blood. 94:2151-2158
Fanconi anemia (FA) is an autosomal recessive disorder characterized by birth defects, increased incidence of malignancy, and progressive bone marrow failure. Bone marrow transplantation is therapeutic and, therefore, FA is a candidate disease for he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de7865e0a4671674c94ed8b4fc1943d2
https://doi.org/10.1182/blood.v94.6.2151
https://doi.org/10.1182/blood.v94.6.2151
Autor:
Glenn Tisman, J. Amin, Malcolm Brenner, S. Malkin, Mercedita Ramos, T. Browder, T. Vu, V. Cordts, G. Luszko, Raynard L. Bateman, V. Flener
Publikováno v:
American Journal of Hematology. 43:226-229
We have recently reported a new and rapid assay to measure plasma holotranscobalamin II (holo TC II) as a means of exploring vitamin B12 status. In order to further evaluate the significance of plasma holoTC II in determining tissue cobalamin, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ecc97f02031458109930849e884859
https://doi.org/10.1002/ajh.2830430313
https://doi.org/10.1002/ajh.2830430313
Autor:
Raynard L. Bateman, Markus Grompe, Ronald W. McClard, Milton J. Finegold, Karsten Wursthorn, John F. Witte
Publikováno v:
Molecular Therapy. 13
Mice deficient in the tyrosine catabolic enzyme Fah are an excellent model for liver repopulation by selection. Fah positive cells from several different origins can engraft and correct the phenotype of a Fah-mutant liver. Non-cell based gene therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675d68a38994eebc63a1d81155f1e66b