Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice.

Autor: Yifei Jiang, Raymund Y K Pun, Katrina Peariso, Katherine D Holland, Qingquan Lian, Steve C Danzer

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138178 (2015)

There is a clear link between epilepsy and depression. Clinical data demonstrate a 30-35% lifetime prevalence of depression in patients with epilepsy, and patients diagnosed with depression have a three to sevenfold higher risk of developing epilepsy

Externí odkaz: https://doaj.org/article/955adaa26f9f407089c6ec6c4bbce961

PTEN deletion increases hippocampal granule cell excitability in male and female mice

Autor: Tom Bouley, Katherine D. Holland, Candi L. LaSarge, Salwa R. Arafa, Raymund Y. K. Pun, Shane Rowley, Norberto Garcia-Cairasco, Steve C. Danzer, Shadi Khademi, Victor R. Santos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neurobiology of Disease, Vol 108, Iss, Pp 339-351 (2017)

Deletion of the mTOR pathway inhibitor PTEN from postnatally-generated hippocampal dentate granule cells causes epilepsy. Here, we conducted field potential, whole cell recording and single cell morphology studies to begin to elucidate the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea82ba5c3241880a95cd4421d158611
https://doi.org/10.1016/j.nbd.2017.08.014

Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?

Autor: Candi L. LaSarge, Zhiqing Gu, Raymund Y. K. Pun, Steve C. Danzer, Victor R. Santos

Publikováno v: Exp Neurol

Hyperactivation of the mechanistic target of rapamycin (mTOR) pathway is associated with epilepsy, autism and brain growth abnormalities in humans. mTOR hyperactivation often results from developmental somatic mutations, producing genetic lesions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62684060e05b4b8ce407843e5a2a34aa
https://europepmc.org/articles/PMC6744293/

Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth

Autor: Salwa R. Arafa, Candi L. LaSarge, Raymund Y. K. Pun, Shadi Khademi, Steve C. Danzer

Publikováno v: Experimental neurology. 311

Loss of the mTOR pathway negative regulator PTEN from hippocampal dentate granule cells leads to neuronal hypertrophy, increased dendritic branching and aberrant basal dendrite formation in animal models. Similar changes are evident in humans with mT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb44b33a5f5e7a857418d7283b789ae9
https://pubmed.ncbi.nlm.nih.gov/30268766

Heterogeneous Integration of Adult-Generated Granule Cells into the Epileptic Brain

Autor: Steve C. Danzer, Raymund Y. K. Pun, Hulian Yin, Andreas W. Loepke, Brian L. Murphy, Christian R. Faulkner

Publikováno v: The Journal of Neuroscience. 31:105-117

The functional impact of adult-generated granule cells in the epileptic brain is unclear, with data supporting both protective and maladaptive roles. These conflicting findings could be explained if new granule cells integrate heterogeneously, with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4a9de9d682cbedede299572c8f5e1f
https://doi.org/10.1523/jneurosci.2728-10.2011