Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Raymund Machovich"'
Autor:
Kraszimir Nikolaev Kolev, Zoltán Varga, Raymund Machovich, Attila Bóta, Zsolt Rottenberger, László Szabó, Colin Longstaff, Erzsébet Komorowicz
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g. decorin) at sites of fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546c084cc30d13f541a74d2c75ad403f
https://doi.org/10.1111/jth.12112
https://doi.org/10.1111/jth.12112
Publikováno v:
Thrombosis Research
Introduction Platelet adhesion to collagen under high shear rates depends on the optimal size of the von Willebrand factor (VWF) multimers, which is determined by their limited proteolysis. The present study attempts to identify the role of hemostati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdafd4befbeffe36944122a2efb8c8a
Autor:
László Szabó, Krasimir Kolev, Kiril Tenekedjiev, Colin Longstaff, Raymund Machovich, Marta M.C.G. Silva, Péter Sótonyi, Nikolett Wohner
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:2306-2313
Objective— Arterial thrombi contain variable amounts of red blood cells (RBCs), which interact with fibrinogen through an eptifibatide-sensitive receptor and modify the structure of fibrin. In this study, we evaluated the modulator role of RBCs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477d30cc27babeeb5251e8012d03a5de
https://doi.org/10.1161/atvbaha.111.229088
https://doi.org/10.1161/atvbaha.111.229088
Autor:
László Szabó, Péter Sótonyi, Raymund Machovich, Marta M.C.G. Silva, Imre Varjú, Krasimir Kolev, Kiril Tenekedjiev, Colin Longstaff
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:979-986
See also Weisel JW. Stressed fibrin lysis. This issue, pp 977–8. Summary. Background: Recent data indicate that stretching forces cause a dramatic decrease in clot volume accompanied by gross conformational changes of fibrin structure. Objective: T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dbe0f6af7a5235a5ef285bb126508c
https://doi.org/10.1111/j.1538-7836.2011.04203.x
https://doi.org/10.1111/j.1538-7836.2011.04203.x
Autor:
Nikolett Wohner, László Szabó, Erzsébet Komorowicz, Péter Sótonyi, Raymund Machovich, Zsófia Keresztes, Kraszimir Nikolaev Kolev
Publikováno v:
Journal of Thrombosis and Haemostasis
Background: Under high shear stress platelets adhere preferentially to the adventitia layer of the arterial vessel wall in a von Willebrand factor (VWF)-dependent manner. Objective: The present study was undertaken in an attempt to characterize the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d24f36a35edf287f25412524cb60c1
https://doi.org/10.1111/j.1538-7836.2010.03890.x
https://doi.org/10.1111/j.1538-7836.2010.03890.x
Publikováno v:
Thrombosis and Haemostasis. 103:291-298
SummaryThe formation of platelet-rich thrombi under high shear rates requires both fibrinogen and von Willebrand factor (VWF) as molecular adhesives between platelets. We attempted to describe the role of VWF as a potential substrate and modulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc387532fea5ea2313d286700c5b5312
https://doi.org/10.1160/th09-07-0420
https://doi.org/10.1160/th09-07-0420
Autor:
Raymund Machovich, Balázs Váradi, Colin Longstaff, Péter Sótonyi, F. Timár, Gyöngyi Rábai, V. Kristóf, Krasimir Kolev
Publikováno v:
Journal of Thrombosis and Haemostasis
Summary. Background: Thrombolysis is conventionally regarded as dissolution of the fibrin matrix of thrombi by plasmin, but the structure of clots in vivo includes additional constituents (proteins, phospholipids) that modulate their solubilization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6957a18cfafbe0179c25dfb470f8a8ab
https://doi.org/10.1111/j.1538-7836.2007.02556.x
https://doi.org/10.1111/j.1538-7836.2007.02556.x
Publikováno v:
Biochemical and Biophysical Research Communications. 341:736-741
Certain denatured proteins function as cofactors in the activation of plasminogen by tissue-type plasminogen activator. The present study approached the structural requirements for the cofactor activity of a model protein (human serum albumin). Heat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f8cd9759a697bf29fa289ac1b0b042
https://doi.org/10.1016/j.bbrc.2006.01.027
https://doi.org/10.1016/j.bbrc.2006.01.027
Publikováno v:
Current Medicinal Chemistry-Cardiovascular & Hematological Agents. 3:341-355
Thrombolysis is conventionally regarded as dissolution of the fibrin matrix of thrombi by plasmin, a protease generated by plasminogen activators from its inactive precursor, plasminogen. Typically plasminogen activation occurs on the surface of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bff510757af085faa5ec12c7788a5e
https://doi.org/10.2174/156801605774322337
https://doi.org/10.2174/156801605774322337
Autor:
István Léránt, Krasimir Kolev, Judit Skopál, Zoltán Zsolt Nagy, Raymund Machovich, Anna Kelemen
Publikováno v:
Thrombosis and Haemostasis. 94:82-87
SummaryImmunoglobulin G (IgG) isolated from the blood plasma of a patient with secondary antiphospholipid syndrome (APS) expresses fibrinogen-clotting and amidolytic activity (the thrombin activity in 20 μmole IgG is equivalent to approximately 5 nm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e26e2b8fd459456ac337dd8ea769469
https://doi.org/10.1160/th04-11-0766
https://doi.org/10.1160/th04-11-0766