Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Raymund A. C. Roos"'
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Autor:
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory
Publikováno v:
Brain and Behavior, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecou
Externí odkaz:
https://doaj.org/article/14760f7b295f464cbc8b231b3d170168
Autor:
Joyce C. F. Heffels, Irma H. J. Everink, Mayke Oosterloo, Raymund A. C. Roos, Jos M. G. A. Schols
Publikováno v:
BMC Palliative Care, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background Nursing home residents with early-onset neurodegenerative diseases are often younger in comparison with other residents, and need different, often more complex care. Accordingly, the measurements currently used for measuring quali
Externí odkaz:
https://doaj.org/article/14edea3f6e4a415988818f7a4ebed43f
Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington’s Disease
Autor:
Nina M. Mansoor, Tishok Vanniyasingam, Ian Malone, Nicola Z. Hobbs, Elin Rees, Alexandra Durr, Raymund A. C. Roos, Bernhard Landwehrmeyer, Sarah J. Tabrizi, Eileanoir B. Johnson, Rachael I. Scahill
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation,
Externí odkaz:
https://doaj.org/article/026f447a265141ffb249f5f1aaf36811
Autor:
Christopher D. Rowley, Sarah J. Tabrizi, Rachael I. Scahill, Blair R. Leavitt, Raymund A. C. Roos, Alexandra Durr, Nicholas A. Bock
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by neuronal cell death. Although medium spiny neurons in the striatum are predominantly affected, other brain regions including the cerebral cortex also degener
Externí odkaz:
https://doaj.org/article/5dec07ffb63d49aab552aecab8b726ca
Autor:
Gaby J. Ritfeld, Ajay Patel, Alexander Chou, Tabitha L. Novosat, Deborah G. Castillo, Raymund A. C. Roos, Martin Oudega Ph.D.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
The ability of intraspinal bone marrow stromal cell (BMSC) transplants to elicit repair is thought to result from paracrine effects by secreted trophic factors including brain-derived neurotrophic factor (BDNF). Here we used gene therapy to increase
Externí odkaz:
https://doaj.org/article/3a8faca6d5ee4b35b28fca6d3423af88
Autor:
Gaby J. Ritfeld, Rishi D. S. Nandoe Tewarie, Katarina Vajn, Sahar T. Rahiem, Andres Hurtado, Dane F. Wendell, Raymund A. C. Roos, Martin Oudega
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Bone marrow stromal cell (BMSC) transplantation has shown promise for repair of the spinal cord. We showed earlier that a BMSC transplant limits the loss of spinal nervous tissue after a contusive injury. Here, we addressed the premise that BMSC-medi
Externí odkaz:
https://doaj.org/article/2c3b41efab6749e0a63fa539a7bf5668
Autor:
null Carlos Estevez‐Fraga, null Michael S. Elmalem, null Marina Papoutsi, null Alexandra Durr, null Elin M. Rees, null Nicola Z. Hobbs, null Raymund A. C. Roos, null Bernhard Landwehrmeyer, null Blair R. Leavitt, null Douglas R. Langbehn, null Rachael I. Scahill, null Geraint Rees, null Sarah J. Tabrizi, null Sarah Gregory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bc68627b3897b4161c7070f737513f
https://doi.org/10.1002/brb3.2940/v2/response1
https://doi.org/10.1002/brb3.2940/v2/response1
Autor:
Oliver W J, Quarrell, Martha A, Nance, Peg, Nopoulos, Ralf, Reilmann, Mayke, Oosterloo, Sarah J, Tabrizi, Hannah, Furby, Carsten, Saft, Raymund A C, Roos, Ferdinando, Squitieri, G Bernhard, Landwehrmeyer, Jean-Marc, Burgunder
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 34(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8fc8abd5fbf7558e0af0cf0480d0628
https://pubmed.ncbi.nlm.nih.gov/30788860
https://pubmed.ncbi.nlm.nih.gov/30788860
Publikováno v:
Movement disorders clinical practice. 5(5)
BACKGROUND: The standard clinical assessment tool in Huntington's disease is the Unified Huntington's Disease Rating Scale (UHDRS). In patients with advanced Huntington's disease ceiling and floor effects of the UHDRS hamper the detection of changes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c51fc1ae7807cf1d94eaef12dd4f85a6
https://pubmed.ncbi.nlm.nih.gov/30515443
https://pubmed.ncbi.nlm.nih.gov/30515443
Autor:
Jorien M M, van der Burg, Sarah L, Gardiner, Albert C, Ludolph, G Bernhard, Landwehrmeyer, Raymund A C, Roos, N Ahmad, Aziz
Publikováno v:
Annals of neurology. 82(3)
Unintended weight loss is a hallmark of Huntington disease (HD), but it is unknown to what extent weight loss impacts the rate of disease progression. Therefore, using longitudinal data from the Enroll-HD study, we assessed the association between ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::395d75ffd549acf1d045c239cd596798
https://pubmed.ncbi.nlm.nih.gov/28779551
https://pubmed.ncbi.nlm.nih.gov/28779551