Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Raymund A. C. Roos"'
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Autor:
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory
Publikováno v:
Brain and Behavior, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecou
Externí odkaz:
https://doaj.org/article/14760f7b295f464cbc8b231b3d170168
Autor:
Joyce C. F. Heffels, Irma H. J. Everink, Mayke Oosterloo, Raymund A. C. Roos, Jos M. G. A. Schols
Publikováno v:
BMC Palliative Care, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background Nursing home residents with early-onset neurodegenerative diseases are often younger in comparison with other residents, and need different, often more complex care. Accordingly, the measurements currently used for measuring quali
Externí odkaz:
https://doaj.org/article/14edea3f6e4a415988818f7a4ebed43f
Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington’s Disease
Autor:
Nina M. Mansoor, Tishok Vanniyasingam, Ian Malone, Nicola Z. Hobbs, Elin Rees, Alexandra Durr, Raymund A. C. Roos, Bernhard Landwehrmeyer, Sarah J. Tabrizi, Eileanoir B. Johnson, Rachael I. Scahill
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation,
Externí odkaz:
https://doaj.org/article/026f447a265141ffb249f5f1aaf36811
Autor:
null Carlos Estevez‐Fraga, null Michael S. Elmalem, null Marina Papoutsi, null Alexandra Durr, null Elin M. Rees, null Nicola Z. Hobbs, null Raymund A. C. Roos, null Bernhard Landwehrmeyer, null Blair R. Leavitt, null Douglas R. Langbehn, null Rachael I. Scahill, null Geraint Rees, null Sarah J. Tabrizi, null Sarah Gregory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bc68627b3897b4161c7070f737513f
https://doi.org/10.1002/brb3.2940/v2/response1
https://doi.org/10.1002/brb3.2940/v2/response1
Autor:
Christopher D. Rowley, Sarah J. Tabrizi, Rachael I. Scahill, Blair R. Leavitt, Raymund A. C. Roos, Alexandra Durr, Nicholas A. Bock
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by neuronal cell death. Although medium spiny neurons in the striatum are predominantly affected, other brain regions including the cerebral cortex also degener
Externí odkaz:
https://doaj.org/article/5dec07ffb63d49aab552aecab8b726ca
Autor:
Jessica Y Winder, Raymund A C Roos
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193866 (2018)
Different oculomotor abnormalities have been reported to occur in premanifest Huntington's disease. The aim of this study is to investigate which oculomotor items of the Unified Huntington's Disease Rating Scale (UHDRS) are affected in premanifest in
Externí odkaz:
https://doaj.org/article/dceec76fa030463592a74c50fd21d632
Autor:
Leire Valcárcel-Ocete, Asier Fullaondo, Gorka Alkorta-Aranburu, María García-Barcina, Raymund A C Roos, Lena E Hjermind, Carsten Saft, Marina Frontali, Ralf Reilmann, Hugh Rickards, REGISTRY investigators of the European Huntington’s Disease Network (EHDN), Ana M Zubiaga, Ana Aguirre
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197975 (2018)
Huntington's disease (HD) age of onset (AO) is mainly determined by the length of the CAG repeat expansion in the huntingtin gene. The remaining AO variability has been attributed to other little-known factors. A factor that has been associated with
Externí odkaz:
https://doaj.org/article/40cbccc9864f42288a97f889c37be2d2
Autor:
Gaby J. Ritfeld, Ajay Patel, Alexander Chou, Tabitha L. Novosat, Deborah G. Castillo, Raymund A. C. Roos, Martin Oudega Ph.D.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
The ability of intraspinal bone marrow stromal cell (BMSC) transplants to elicit repair is thought to result from paracrine effects by secreted trophic factors including brain-derived neurotrophic factor (BDNF). Here we used gene therapy to increase
Externí odkaz:
https://doaj.org/article/3a8faca6d5ee4b35b28fca6d3423af88
Autor:
Leire Valcárcel-Ocete, Gorka Alkorta-Aranburu, Mikel Iriondo, Asier Fullaondo, María García-Barcina, José Manuel Fernández-García, Elena Lezcano-García, José María Losada-Domingo, Javier Ruiz-Ojeda, Amaia Álvarez de Arcaya, José María Pérez-Ramos, Raymund A C Roos, Jørgen E Nielsen, Carsten Saft, REGISTRY investigators of the European Huntington's Disease Network, Ana M Zubiaga, Ana Aguirre
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131573 (2015)
Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it co
Externí odkaz:
https://doaj.org/article/c7ff862050a64eca938de23d82fc92fb
Autor:
Silke Metzger, Carolin Walter, Olaf Riess, Raymund A C Roos, Jørgen E Nielsen, David Craufurd, REGISTRY Investigators of the European Huntington’s Disease Network, Huu Phuc Nguyen
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68951 (2013)
The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify t
Externí odkaz:
https://doaj.org/article/9713d43f9dc645bfbdf87cb9a5a9c8f3