Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Raymonda, Romberg"'
Autor:
Justus Hollander, Raymonda Romberg, Alexander Binning, Michel Kruit, Terry Smith, Eveline L. A. van Dorp, Albert Dahan
Publikováno v:
The Clinical Journal of Pain. 23:197-203
OBJECTIVES To determine the dose-response effect of intravenous morphine-6-glucuronide (M6G) on acute postoperative pain. METHODS Patients undergoing knee replacement surgery under spinal anesthesia were randomly assigned to 1 of 4 single intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025097982d40b260e319e03dbb9c18c1
https://doi.org/10.1097/ajp.0b013e31802b4f6a
https://doi.org/10.1097/ajp.0b013e31802b4f6a
Autor:
Meindert Danhof, Raymonda Romberg, Ashraf Yassen, Erik Olofsen, Albert Dahan, Luc J. Teppema, Elise Sarton
Publikováno v:
Clinical Pharmacology & Therapeutics. 81:50-58
The objective of this study was to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship of buprenorphine and fentanyl for the respiratory depressant effect in healthy volunteers. Data on the time course of the ventilatory response at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e91bf93aa8350cdecca90d2367ca1aa
https://doi.org/10.1038/sj.clpt.6100025
https://doi.org/10.1038/sj.clpt.6100025
Autor:
Meindert Danhof, Luc J. Teppema, Erik Olofsen, Elise Sarton, Raymonda Romberg, Ashraf Yassen, Eveline L. A. van Dorp, Albert Dahan
Publikováno v:
Anesthesiology. 105:51-57
Background The objective of this investigation was to examine the ability of the opioid antagonist naloxone to reverse respiratory depression produced by the mu-opioid analgesic, buprenorphine, in healthy volunteers. The studies were designed in ligh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf793b9ba63dd14da6ae0ae6eb047ea
https://doi.org/10.1097/00000542-200607000-00012
https://doi.org/10.1097/00000542-200607000-00012
Publikováno v:
Anesthesia & Analgesia. 102:1789-1797
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. In contrast to morphine, M6G is not metabolized but excreted vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e8d0f4dad29a1e637b247388b6f5fe
https://doi.org/10.1213/01.ane.0000217197.96784.c3
https://doi.org/10.1213/01.ane.0000217197.96784.c3
Publikováno v:
Anesthesiology. 104:1232-1242
Background The objective of this investigation was to characterize the pharmacokinetic-pharmacodynamic relation of buprenorphine's antinociceptive effect in healthy volunteers. Methods Data on the time course of the antinociceptive effect after intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920c466761903b3384fc73912ec40697
https://doi.org/10.1097/00000542-200606000-00019
https://doi.org/10.1097/00000542-200606000-00019
Autor:
Raymonda Romberg, Luc J. Teppema, Meindert Danhof, Elise Sarton, Albert Dahan, Ashraf Yassen, Erik Olofsen
Publikováno v:
British Journal of Anaesthesia. 96:627-632
Background We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1644346cee522d57e4668d2895932bbe
https://doi.org/10.1093/bja/ael051
https://doi.org/10.1093/bja/ael051
Publikováno v:
The Journal of Physiology. 572:849-856
The carbonic anhydrase inhibitor acetazolamide may have both inhibitory and stimulatory effects on breathing. In this placebo-controlled double-blind study we measured the effect of an intravenous dose (4 mg kg−1) of this agent on the acute isocapn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea443ac4421787ca2ab2cdfa8157e6e
https://doi.org/10.1113/jphysiol.2005.104174
https://doi.org/10.1113/jphysiol.2005.104174
Autor:
Frank H. M. Engbers, Albert Dahan, Raymonda Romberg, Erik Olofsen, Hans Bijl, René Mooren, Benjamin Kest
Publikováno v:
Anesthesiology. 103:130-139
Background To assess whether patient sex contributes to the interindividual variability in alfentanil analgesic sensitivity, the authors compared male and female subjects for pain sensitivity after alfentanil using a pharmacokinetic-pharmacodynamic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe455f9e14412bb4a18f99a488f46174
https://doi.org/10.1097/00000542-200507000-00020
https://doi.org/10.1097/00000542-200507000-00020
Publikováno v:
Anesthesiology. 101:1201-1209
Background: To study the influence of morphine on chemical control of breathing relative to the analgesic properties of morphine, the authors quantified morphine-induced analgesia and respiratory depression in a single group of healthy volunteers. Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d141a816119a935ca95b10de5765f9
https://doi.org/10.1097/00000542-200411000-00021
https://doi.org/10.1097/00000542-200411000-00021
Autor:
Peter E.M. Taschner, Albert Dahan, Elise Sarton, Jan den Hartigh, Erik Olofsen, Raymonda Romberg
Publikováno v:
Anesthesiology. 100:120-133
Background Morphine-6-glucuronide (M6G) is a metabolite of morphine and a micro-opioid agonist. To quantify the potency and speed of onset-offset of M6G and explore putative sex dependency, the authors studied the pharmacokinetics and pharmacodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78c65f3442e7d7439519890692d9bf1
https://doi.org/10.1097/00000542-200401000-00021
https://doi.org/10.1097/00000542-200401000-00021