Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Raymond W. Bourdeau"'
Autor:
Kevin Dooley, Nuruddeen D. Lewis, Raymond W. Bourdeau, Williams Douglas E, Christine McCoy, Kelvin Xi Zhang, Katherine Kirwin, Joyoti Dey, Marc Grenley, Jorge Sanchez-Salazar, Nikki L. Ross, Agata Villiger-Oberbek, Su Chul Jang, Sriram Sathyanarayanan, Tong Zi, Joanne Lim, Kyriakos D. Economides, Ke Xu, William K. Dahlberg, Raymond J. Moniz, Scott Estes, Rane A. Harrison, Chang Ling Sia
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models. However, CDNs administered intratumorally also promote STING activation leading to direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b76e65940414bd13ef06ef91b2232ab
https://doi.org/10.1038/s42003-021-02004-5
https://doi.org/10.1038/s42003-021-02004-5
Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI
Autor:
George J. Lu, Martin Kunth, Mikhail G. Shapiro, Audrey Lee-Gosselin, Anupama Lakshmanan, Arash Farhadi, David Maresca, Leif Schröder, Judy Yan, Christopher Witte, Raymond W. Bourdeau, Melissa Yin, Suchita P. Nety, Dina Malounda, F. Stuart Foster
Publikováno v:
Nature Protocols. 12:2050-2080
Gas vesicles are a unique class of gas-filled protein nanostructures whose physical properties allow them to serve as highly sensitive imaging agents for ultrasound and magnetic resonance imaging (MRI), detectable at sub-nanomolar concentrations. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90c70dc3f122180d4218cd1f4f56a3e
https://doi.org/10.1038/nprot.2017.081
https://doi.org/10.1038/nprot.2017.081
Autor:
Gabrielle H. Ho, Mikhail G. Shapiro, Martin Kunth, Anupama Lakshmanan, Bill Ling, Raymond W. Bourdeau, George J. Lu, Arash Farhadi, Leif Schröder
Ultrasound and hyperpolarized magnetic resonance imaging enable the visualization of biological processes in deep tissues. However, few molecular contrast agents are available to connect these modalities to specific aspects of biological function. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17255104f4aaa9a9b9868d4d289abb0e
https://resolver.caltech.edu/CaltechAUTHORS:20180226-134658661
https://resolver.caltech.edu/CaltechAUTHORS:20180226-134658661
Autor:
Arash Farhadi, Anupama Lakshmanan, Audrey Lee-Gosselin, Suchita P. Nety, Sripriya Ravindra Kumar, Raymond W. Bourdeau, Mikhail G. Shapiro
Publikováno v:
Nature
The mammalian microbiome has many important roles in health and disease1,2, and genetic engineering is enabling the development of microbial therapeutics and diagnostics3,4,5,6,7. A key determinant of the activity of both natural and engineered micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f4c964d329a33bc6ab3083b8ba5466
https://resolver.caltech.edu/CaltechAUTHORS:20171102-124711465
https://resolver.caltech.edu/CaltechAUTHORS:20171102-124711465
Autor:
Johan M. Melis, Emmanuel Cherin, Dennis M. Kochmann, F. Stuart Foster, Raymond W. Bourdeau, Mikhail G. Shapiro, Melissa Yin
Gas vesicles (GVs) are a new and unique class of biologically derived ultrasound contrast agents with sub-micron size whose acoustic properties have not been fully elucidated. In this study, we investigated the acoustic collapse pressure and behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6413d3ec3b0c313c674101167868a3
https://europepmc.org/articles/PMC5385285/
https://europepmc.org/articles/PMC5385285/
Autor:
Kevin Dooley, Rane A. Harrison, Christine McCoy, Chang Ling Sia, Raymond J. Moniz, Damian Houde, Tong Zi, Scott Estes, Ke Xu, Nikki L. Ross, Raymond W. Bourdeau, Kyriakos D. Economides, Sriram Sathyanarayanan, Agata Villiger-Oberbek, Nuruddeen D. Lewis, Jorge Sanchez-Salazar, William K. Dahlberg, Su Chul Jang
Publikováno v:
Cancer Research. 79:944-944
Background: The Stimulator of Interferon Genes (STING) pathway is an attractive target in immuno-oncology. Selective activation of the STING pathway in antigen presenting cells (APCs) is essential for eliciting a potent and specific anti-tumor immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1f76b93374d5c3017f3be63b876236
https://doi.org/10.1158/1538-7445.am2019-944
https://doi.org/10.1158/1538-7445.am2019-944
Autor:
Mikhail G. Shapiro, Johan M. Melis, Anupama Lakshmanan, Audrey Lee-Gosselin, David Maresca, Dennis M. Kochmann, Yu-Li Ni, Raymond W. Bourdeau
Publikováno v:
Applied Physics Letters. 110:073704
Ultrasound imaging is widely used to probe the mechanical structure of tissues and visualize blood flow. However, the ability of ultrasound to observe specific molecular and cellular signals is limited. Recently, a unique class of gas-filled protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470007dbdbb731946cdf36fe9836eef7
https://doi.org/10.1063/1.4976105
https://doi.org/10.1063/1.4976105
Autor:
Richard F. Rest, Raymond W. Bourdeau, Mitch L. Villereal, Enrico Malito, Wei-Jen Tang, Alexandre Chenal, Eugene B. Chang, Mark W. Musch, Elise M. Mosser, Brian L. Bishop
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
Journal of Biological Chemistry, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
Journal of Biological Chemistry, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
International audience; Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis, the etiologic agent for anthrax. Growing evidence suggests the involvement of ALO in anthrax pathogenesis. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1793df6fcebc99126dcd9422abef133f
https://hal-pasteur.archives-ouvertes.fr/pasteur-01540766
https://hal-pasteur.archives-ouvertes.fr/pasteur-01540766
Publikováno v:
Biophysical Journal. 100:583a-584a
NaK is a non-selective monovalent cation channel from Bacillus cereus. Despite being unable to discriminate between Na+ and K+, NaK shows high sequence similarity to other K+ channels. Based on recently solved crystal structures in the closed and put
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a1b89129d0e7eacb4c8fe57551bba0
https://doi.org/10.1016/j.bpj.2010.12.3371
https://doi.org/10.1016/j.bpj.2010.12.3371
Autor:
Hind Lal, Guangrong Lu, Wei-Jen Tang, Jonathan Mock, Raymond W. Bourdeau, Stephen H. Leppla, Arthur E. Frankel, David E. Dostal, Linley E. Watson
Publikováno v:
Frontiers in Bioscience. 12:4670
Fatalities due to anthrax are associated with severe hypotension suggesting that the toxins generated from Bacillus anthracis, lethal toxin (LeTx) and edema toxin (EdTx), have cardiovascular effects. Here, we demonstrate the effects of these toxins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a970d46d5de151ee5a4c0e0260514ac
https://doi.org/10.2741/2416
https://doi.org/10.2741/2416